{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:30:10Z","timestamp":1754163010031,"version":"3.41.2"},"reference-count":30,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"unspecified","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Medtronic Limited","award":["ISR-2016-10773"],"award-info":[{"award-number":["ISR-2016-10773"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Gastroenterol"],"accepted":{"date-parts":[[2023,2,27]]},"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Barrett\u2019s oesophagus (BO) is a precursor lesion, via dysplastic phases, to oesophageal adenocarcinoma. Although overall risk from BO is low, it has been shown to adversely affect health-related quality of life (HRQOL). The aim was to compare dysplastic BO patients\u2019 HRQOL pre-endoscopic therapy (pre-ET) and post-ET. The pre-ET BO group was also compared with other cohorts: non-dysplastic BO (NDBO), those with colonic polyps, gastro-oesophageal reflux disease (GORD) and healthy volunteers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Participants in the pre-ET cohort were recruited prior to their endotherapy and HRQOL questionnaires provided pre-ET and post-ET. Wilcoxon rank test was used to compare the pre-ET and post-ET findings. The Pre-ET group was compared to the other cohorts\u2019 HRQOL results using multiple linear regression analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Pre-ET group of 69 participants returned the questionnaires prior to and 42 post-ET. Both the pre-ET and post-ET group showed similar levels of cancer worry, despite the treatment. No statistical significance was found for symptoms scores, anxiety and depression or general health measures with the Short Form-36 (SF-36) Score. Education for the BO patients was overall lacking with many of the pre-ET group still reporting unanswered questions about their disease.<\/jats:p>\n                  <jats:p>The Pre-ET group was compared with NDBO group (N=379), GORD (N=132), colonic polyp patients (N=152) and healthy volunteers (N=48). Cancer worry was similar between the NDBO group and the Pre-ET group, despite their lower risk of progression. GORD patients had worse symptom scores from a reflux and heartburn perspective. Only the healthy group has significantly better scores in the SF-36 and improved hospital anxiety and depression scores.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These findings suggest that there is a need to improve HRQOL for patients with BO. This should include improved education and devising-specific patient-reported outcome measures for BO to capture relevant areas of HRQOL in future studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjgast-2022-001091","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T11:15:48Z","timestamp":1681211748000},"page":"e001091","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Quality of life measures in dysplastic Barrett\u2019s oesophagus are comparable to patients with non-dysplastic Barrett\u2019s oesophagus and do not improve after endoscopic therapy"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6521-2133","authenticated-orcid":false,"given":"Elizabeth","family":"Ratcliffe","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Wrightington, Wigan and Leigh NHS Foundation Trust, Wigan, UK"},{"name":"Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Britton","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Northern Care Alliance NHS Foundation Trust, Salford, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calvin","family":"Heal","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Division of Population Health, Health Services Research & Primary Care, The University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Keld","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Wrightington, Wigan and Leigh NHS Foundation Trust, Wigan, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Murgatroyd","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Bolton NHS Foundation Trust, Bolton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Willert","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Manchester University NHS Foundation Trust, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6158-5135","authenticated-orcid":false,"given":"John","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK"},{"name":"Department of Gastroenterology, Northern Care Alliance NHS Foundation Trust, Salford, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9640-7427","authenticated-orcid":false,"given":"Shaheen","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK"},{"name":"Department of Gastroenterology, Northern Care Alliance NHS Foundation Trust, Salford, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeng","family":"Ang","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK"},{"name":"Department of Gastroenterology, Northern Care Alliance NHS Foundation Trust, Salford, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"2025073013452690000_10.1.e001091.1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321365"},{"key":"2025073013452690000_10.1.e001091.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103042"},{"key":"2025073013452690000_10.1.e001091.3","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr203"},{"key":"2025073013452690000_10.1.e001091.4","unstructured":"Cancer Research . 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