{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:41:42Z","timestamp":1793410902966,"version":"4.5.0"},"reference-count":58,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T00:00:00Z","timestamp":1724457600000},"content-version":"unspecified","delay-in-days":236,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Moriya Elizabeth Vine Fund"},{"name":"DVCR-Start Up Funds, The University of Sydney"},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EC1010A"],"award-info":[{"award-number":["01EC1010A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["EU FP7 HEALTH-F2-2010-241909"],"award-info":[{"award-number":["EU FP7 HEALTH-F2-2010-241909"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Ment Health"],"accepted":{"date-parts":[[2024,6,20]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The mental health benefits of cannabidiol (CBD) are promising but can be inconsistent, in part due to challenges in defining an individual\u2019s effective dosage. In schizophrenia, alterations in anandamide (AEA) concentrations, an endocannabinoid (eCB) agonist of the eCB system, reflect positively on treatment with CBD. Here, we expanded this assessment to include eCBs alongside AEA congeners, comparing phytocannabinoids and dosage in a clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Liquid chromatography-tandem mass spectrometry quantified changes in serum levels of AEA, 2-arachidonoylglycerol (2-AG), alongside AEA-related compounds oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), which were attained from two independent, parallel-designed, clinical trials investigating single, oral CBD (600 or 800\u2009mg), delta-9-tetrahydrocannabinol (\u0394\n                      <jats:sup>9<\/jats:sup>\n                      -THC, 10 or 20\u2009mg) and combination administration (CBD|800 mg+\u0394\n                      <jats:sup>9<\/jats:sup>\n                      -THC|20\u2009mg) in healthy volunteers (HVs, n=75). Concentrations were measured at baseline (t=0), 65 and 160\u2009min post administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CBD-led increases in AEA (1.6-fold), OEA and PEA (1.4-fold) were observed following a single 800\u2009mg (p\n                      <jats:sub>corr<\/jats:sub>\n                      &lt;0.05) but not 600\u2009mg dosage. Declining AEA was observed with \u0394\n                      <jats:sup>9<\/jats:sup>\n                      -THC at 10\u2009mg (\u22121.3-fold) and 20\u2009mg (\u22121.4-fold) but restored to baseline levels by 160\u2009min. CBD+\u0394\n                      <jats:sup>9<\/jats:sup>\n                      -THC yielded the highest increases in AEA (2.1-fold), OEA (1.9-fold) and PEA (1.8-fold) without reaching a maximal response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      CBD-administered effects towards AEA, OEA and PEA are consistent with phase II trials reporting clinical improvement for acute schizophrenia (CBD\u2265800\u2009mg). Including \u0394\n                      <jats:sup>9<\/jats:sup>\n                      -THC appears to enhance the CBD-induced response towards AEA and its congeners. Our results warrant further investigations into the potential of these lipid-derived mediators as metabolic measures for CBD dose prescription and co-cannabinoid administration.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjment-2024-301027","type":"journal-article","created":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T10:50:13Z","timestamp":1724583013000},"page":"e301027","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Dose-dependent effects of oral cannabidiol and delta-9-tetrahydrocannabinol on serum anandamide and related N-acylethanolamines in healthy volunteers"],"prefix":"10.1136","volume":"27","clinical-trial-number":[{"clinical-trial-number":"nct02487381","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5896-2638","authenticated-orcid":false,"given":"Timothy A","family":"Couttas","sequence":"first","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Boost","sequence":"additional","affiliation":[{"name":"Dept. of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany"},{"name":"Endosane Pharmaceuticals GmbH, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0167-3832","authenticated-orcid":false,"given":"Franziska","family":"Pahlisch","sequence":"additional","affiliation":[{"name":"Dept. of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1618-2510","authenticated-orcid":false,"given":"Eliska B","family":"Sykorova","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia"},{"name":"Dept. of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3890-3742","authenticated-orcid":false,"given":"Juliane K","family":"Mueller","sequence":"additional","affiliation":[{"name":"Dept. of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany"},{"name":"Dept. of Psychiatry, Psychosomatics and Psychotherapy, Goethe-Universitat Frankfurt am Main, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-7404","authenticated-orcid":false,"given":"Beverly","family":"Jieu","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1871-9173","authenticated-orcid":false,"given":"Judith E","family":"Leweke","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia"},{"name":"Dept. of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5878-4149","authenticated-orcid":false,"given":"Inga","family":"Dammann","sequence":"additional","affiliation":[{"name":"Dept. of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany"},{"name":"Endosane Pharmaceuticals GmbH, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7263-8907","authenticated-orcid":false,"given":"Anna E","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia"},{"name":"Endosane Pharmaceuticals GmbH, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Dept. of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0767-0301","authenticated-orcid":false,"given":"Oliver","family":"Grimm","sequence":"additional","affiliation":[{"name":"Dept. of Psychiatry, Psychosomatics and Psychotherapy, Goethe-Universitat Frankfurt am Main, Frankfurt am Main, Germany"},{"name":"Dept. of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3577-2778","authenticated-orcid":false,"given":"Frank","family":"Enning","sequence":"additional","affiliation":[{"name":"Dept. of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany"},{"name":"Dept. of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4809-5398","authenticated-orcid":false,"given":"Herta","family":"Flor","sequence":"additional","affiliation":[{"name":"Dept. of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5619-1123","authenticated-orcid":false,"given":"Andreas","family":"Meyer-Lindenberg","sequence":"additional","affiliation":[{"name":"Dept. of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8324-6756","authenticated-orcid":false,"given":"Dagmar","family":"Koethe","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-1846","authenticated-orcid":false,"given":"Cathrin","family":"Rohleder","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia"},{"name":"Dept. of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany"},{"name":"Endosane Pharmaceuticals GmbH, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-195X","authenticated-orcid":false,"given":"F Markus","family":"Leweke","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia"},{"name":"Dept. of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,8,25]]},"reference":[{"key":"2025082623021673000_27.1.e301027.1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s40263-018-0539-z","article-title":"Role of the Endocannabinoid System in the Pathophysiology of Schizophrenia: Implications for Pharmacological Intervention","volume":"32","author":"Leweke","year":"2018","journal-title":"CNS Drugs"},{"key":"2025082623021673000_27.1.e301027.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(96)00426-1"},{"key":"2025082623021673000_27.1.e301027.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0284-z"},{"key":"2025082623021673000_27.1.e301027.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.12.006"},{"key":"2025082623021673000_27.1.e301027.5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0741627.x"},{"key":"2025082623021673000_27.1.e301027.6","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.112.121178"},{"key":"2025082623021673000_27.1.e301027.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.04.025"},{"key":"2025082623021673000_27.1.e301027.8","doi-asserted-by":"publisher","DOI":"10.2174\/138161212802884843"},{"key":"2025082623021673000_27.1.e301027.9","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.053843"},{"key":"2025082623021673000_27.1.e301027.10","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2012.15","article-title":"Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia","volume":"2","author":"Leweke","year":"2012","journal-title":"Transl Psychiatry"},{"key":"2025082623021673000_27.1.e301027.11","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17030325"},{"key":"2025082623021673000_27.1.e301027.12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.618447"},{"key":"2025082623021673000_27.1.e301027.13","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr4090"},{"key":"2025082623021673000_27.1.e301027.14","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.euroneuro.2018.04.004","article-title":"Probing the endocannabinoid system in healthy volunteers: Cannabidiol alters fronto-striatal resting-state connectivity","volume":"28","author":"Grimm","year":"2018","journal-title":"Eur Neuropsychopharmacol"},{"key":"2025082623021673000_27.1.e301027.15","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2020.576877","article-title":"Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Emotion, Cognition, and Attention: A Double-Blind, Placebo-Controlled, Randomized Experimental Trial in Healthy Volunteers","volume":"11","author":"Woelfl","year":"2020","journal-title":"Front Psychiatry"},{"key":"2025082623021673000_27.1.e301027.16","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1089\/can.2021.0181","article-title":"Simultaneous Assessment of Serum Levels and Pharmacologic Effects of Cannabinoids on Endocannabinoids and N-Acylethanolamines by Liquid Chromatography-Tandem Mass Spectrometry","volume":"8","author":"Couttas","year":"2023","journal-title":"Cannabis Cannabinoid Res"},{"key":"2025082623021673000_27.1.e301027.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2009.04.010"},{"key":"2025082623021673000_27.1.e301027.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2006.11.027"},{"key":"2025082623021673000_27.1.e301027.19","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2008.519"},{"key":"2025082623021673000_27.1.e301027.20","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/372686a0","article-title":"Formation and inactivation of endogenous cannabinoid anandamide in central neurons","volume":"372","author":"Di Marzo","year":"1994","journal-title":"Nature New Biol"},{"key":"2025082623021673000_27.1.e301027.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2012.08.019"},{"key":"2025082623021673000_27.1.e301027.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-3084(00)00192-4"},{"key":"2025082623021673000_27.1.e301027.23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306642200"},{"key":"2025082623021673000_27.1.e301027.24","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.bbalip.2017.08.006","article-title":"Mammalian enzymes responsible for the biosynthesis of N-acylethanolamines","volume":"1862","author":"Hussain","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2025082623021673000_27.1.e301027.25","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1089\/can.2018.0031","article-title":"Cannabidiol\u2019s Upregulation of N-acyl Ethanolamines in the Central Nervous System Requires N-acyl Phosphatidyl Ethanolamine-Specific Phospholipase D","volume":"3","author":"Leishman","year":"2018","journal-title":"Cannabis Cannabinoid Res"},{"key":"2025082623021673000_27.1.e301027.26","doi-asserted-by":"crossref","DOI":"10.3390\/cells13060486","article-title":"Cannabidiol Disrupts Mitochondrial Respiration and Metabolism and Dysregulates Trophoblast Cell Differentiation","volume":"13","author":"Podinic","year":"2024","journal-title":"Cells"},{"key":"2025082623021673000_27.1.e301027.27","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1007\/s00213-018-4885-9","article-title":"The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial","volume":"235","author":"Boggs","year":"2018","journal-title":"Psychopharmacology (Berl)"},{"key":"2025082623021673000_27.1.e301027.28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jpsychires.2023.05.019","article-title":"The impact of cannabidiol treatment on resting state functional connectivity, prefrontal metabolite levels and reward processing in recent-onset patients with a psychotic disorder","volume":"163","author":"van Boxel","year":"2023","journal-title":"J Psychiatr Res"},{"key":"2025082623021673000_27.1.e301027.29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1177\/0269881117735684","article-title":"Medicinal cannabis (Bedrolite) substitution therapy in inpatients with a psychotic disorder and a comorbid cannabis use disorder: A case series","volume":"32","author":"Schipper","year":"2018","journal-title":"J Psychopharmacol"},{"key":"2025082623021673000_27.1.e301027.30","doi-asserted-by":"publisher","DOI":"10.1002\/bms.1200130206"},{"key":"2025082623021673000_27.1.e301027.31","first-page":"56","article-title":"Gonadotropin axis and semen quality in young Swiss men after cannabis consumption: Effect of chronicity and modulation by cannabidiol","volume":"12","author":"Zufferey","year":"2024","journal-title":"Andrology (Los Angel)"},{"key":"2025082623021673000_27.1.e301027.32","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00210-014-0984-2","article-title":"Increased CB2 mRNA and anandamide in human blood after cessation of cannabis abuse","volume":"387","author":"Muhl","year":"2014","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2025082623021673000_27.1.e301027.33","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1177\/02698811221148604","article-title":"Cannabis use is associated with low plasma endocannabinoid Anandamide in individuals with psychosis","volume":"37","author":"Bassir Nia","year":"2023","journal-title":"J Psychopharmacol"},{"key":"2025082623021673000_27.1.e301027.34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/brainsci13101375","article-title":"Circulating Endocannabinoids and N-Acylethanolamines in Individuals with Cannabis Use Disorder-Preliminary Findings","volume":"13","author":"Boachie","year":"2023","journal-title":"Brain Sci"},{"key":"2025082623021673000_27.1.e301027.35","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3182984015"},{"key":"2025082623021673000_27.1.e301027.36","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-023-02410-9","article-title":"Effects of cannabidiol on anandamide levels in individuals with cannabis use disorder: findings from a randomised clinical trial for the treatment of cannabis use disorder","volume":"13","author":"Hua","year":"2023","journal-title":"Transl Psychiatry"},{"key":"2025082623021673000_27.1.e301027.37","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1089\/can.2022.0174","article-title":"Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Plasma Endocannabinoid Levels in Healthy Volunteers: A Randomized Double-Blind Four-Arm Crossover Study","volume":"9","author":"Chester","year":"2024","journal-title":"Cannabis Cannabinoid Res"},{"key":"2025082623021673000_27.1.e301027.38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/dta.1561","article-title":"Quantification of anandamide and 2-arachidonoylglycerol plasma levels to examine potential influences of tetrahydrocannabinol application on the endocannabinoid system in humans","volume":"6","author":"Thieme","year":"2014","journal-title":"Drug Test Anal"},{"key":"2025082623021673000_27.1.e301027.39","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.100"},{"key":"2025082623021673000_27.1.e301027.40","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1422-2"},{"key":"2025082623021673000_27.1.e301027.41","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature20153","article-title":"The effects of \u03949-tetrahydrocannabinol on the dopamine system","volume":"539","author":"Bloomfield","year":"2016","journal-title":"Nature New Biol"},{"key":"2025082623021673000_27.1.e301027.42","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1089\/can.2021.0185","article-title":"The Relationship Between Circulating Endogenous Cannabinoids and the Effects of Smoked Cannabis","volume":"8","author":"Kearney-Ramos","year":"2023","journal-title":"Cannabis Cannabinoid Res"},{"key":"2025082623021673000_27.1.e301027.43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606646200"},{"key":"2025082623021673000_27.1.e301027.44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106261200"},{"key":"2025082623021673000_27.1.e301027.45","doi-asserted-by":"crossref","first-page":"11193","DOI":"10.1002\/anie.201603746","article-title":"Second\u2010Generation Non\u2010Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis","volume":"55","author":"Migliore","year":"2016","journal-title":"Angew Chem Int Ed"},{"key":"2025082623021673000_27.1.e301027.46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01166.x"},{"key":"2025082623021673000_27.1.e301027.47","doi-asserted-by":"publisher","DOI":"10.1021\/bi060163l"},{"key":"2025082623021673000_27.1.e301027.48","doi-asserted-by":"crossref","first-page":"115261","DOI":"10.1016\/j.bcp.2022.115261","article-title":"Biosynthesis and metabolism of endocannabinoids and their congeners from the monoacylglycerol and N-acyl-ethanolamine families","volume":"205","author":"Simard","year":"2022","journal-title":"Biochem Pharmacol"},{"key":"2025082623021673000_27.1.e301027.49","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-5-59","article-title":"Dynamic regulation of the endocannabinoid system: implications for analgesia","volume":"5","author":"Sagar","year":"2009","journal-title":"Mol Pain"},{"key":"2025082623021673000_27.1.e301027.50","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-010-3457-5"},{"key":"2025082623021673000_27.1.e301027.51","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.130"},{"key":"2025082623021673000_27.1.e301027.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.08.026"},{"key":"2025082623021673000_27.1.e301027.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.06.008"},{"key":"2025082623021673000_27.1.e301027.54","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1176\/appi.ajp.2021.21030320","article-title":"Risks and Benefits of Cannabis and Cannabinoids in Psychiatry","volume":"179","author":"Hill","year":"2022","journal-title":"Am J Psychiatry"},{"key":"2025082623021673000_27.1.e301027.55","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200790152"},{"key":"2025082623021673000_27.1.e301027.56","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-018-0578-5"},{"key":"2025082623021673000_27.1.e301027.57","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jamapsychiatry.2019.0970","article-title":"Measuring Disturbance of the Endocannabinoid System in Psychosis: A Systematic Review and Meta-analysis","volume":"76","author":"Minichino","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"2025082623021673000_27.1.e301027.58","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300558"}],"container-title":["BMJ Mental Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjment-2024-301027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:02:31Z","timestamp":1756274551000},"score":1,"resource":{"primary":{"URL":"https:\/\/mentalhealth.bmj.com\/lookup\/doi\/10.1136\/bmjment-2024-301027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,8,25]]},"published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1136\/bmjment-2024-301027"],"URL":"https:\/\/doi.org\/10.1136\/bmjment-2024-301027","relation":{},"ISSN":["2755-9734"],"issn-type":[{"value":"2755-9734","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]}}}