{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:46:19Z","timestamp":1775637979416,"version":"3.50.1"},"reference-count":39,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"unspecified","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["bmjonc"],"accepted":{"date-parts":[[2024,6,26]]},"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Skull base chordoma and chondrosarcoma are distinct sarcomas of the skull base but share significant therapeutic challenges due to their proximity to critical neurovascular structures, making surgical resection difficult. We sought to establish factors associated with outcome predictors in a national cohort of patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>Data for all patients referred with a diagnosis of skull base chordoma or chondrosarcoma from April 2017 to December 2022 were obtained. We performed analyses of data pertaining to the first cohort of patients treated in the UK with proton beam therapy (PBT) to determine factors associated with obtaining gross total resection (GTR) and adequate clearance of the brainstem and optic apparatus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 230 patients with skull base chordoma or chondrosarcoma referred for PBT, 71% were accepted for PBT, with a wide regional variation between referring neurosurgical units (29%\u201393%). Of the first 75 consecutive patients treated with PBT, the only factor predictive of obtaining GTR was surgical resection at a unit with higher volumes of patients accepted for PBT (OR 1.32, 95% CI 1.11 to 1.63, p=0.004). Use of intraoperative MRI (OR 4.84, 95% CI 1.21 to 27.83, p=0.04) and resection at a higher volume unit (OR 1.29, 95% CI 1.07 to 1.64, p=0.013) were associated with increased rates of tumour clearance from the brainstem\/optic apparatus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Treatment at a higher volume centre was a key determinant of the optimal surgical outcome in this cohort. These data support the management of skull base chordomas and chondrosarcomas in higher volume centres where multidisciplinary experience can be accumulated.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjonc-2024-000386","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T12:55:03Z","timestamp":1722257703000},"page":"e000386","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Surgical management of skull base chordomas and chondrosarcomas: insights from a national cohort study"],"prefix":"10.1136","volume":"3","author":[{"given":"Laurence J","family":"Glancz","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Queens Medical Centre, Manchester, UK"},{"name":"School of Medicine, University of Nottingham, Nottingham, UK"},{"name":"Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-7215","authenticated-orcid":false,"given":"Cathal John","family":"Hannan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, UK"},{"name":"The Geoffrey Jefferson Brain Research Centre, Manchester, UK"},{"name":"Division of Neuroscience, School of Biological Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros","family":"Vyziotis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Manchester Centre for Clinical Neuroscience, Salford Royal Hospital, Northern Care Alliance, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian M","family":"Potter","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton-under-Lyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rekha","family":"Siripurapu","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, The Walton Centre NHS Foundation Trust, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj K","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Northern Care Alliance NHS Foundation Trust, Salford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Manchester Centre for Clinical Neuroscience, Salford Royal Hospital, Northern Care Alliance, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew Thomas","family":"King","sequence":"additional","affiliation":[{"name":"The Geoffrey Jefferson Brain Research Centre, Manchester, UK"},{"name":"Department of Neurosurgery, Manchester Centre for Clinical Neuroscience, Salford Royal Hospital, Northern Care Alliance, Manchester, UK"},{"name":"Division of Cardiovascular Sciences, School of Biological Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Hammerbeck-Ward","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal Sussex County Hospital, Brighton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Crellin","sequence":"additional","affiliation":[{"name":"Highly Specialised Commissioning, NHS England, Redditch, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shermaine","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, 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