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reference group and a symptomatic cohort of patients presenting with one of 15 new onset symptoms (abdominal pain, abdominal bloating, rectal bleed, change in bowel habit, dyspepsia, dysphagia, dyspnoea, haemoptysis, haematuria, fatigue, night sweats, weight loss, jaundice, breast lump and post-menopausal bleed).<\/jats:p>\n                    <jats:p>Time-to-event models were used to estimate outcome-specific hazards for site-specific cancer diagnosis and non-cancer mortality and to estimate cumulative incidence up to 12 months following index consultation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data included 1 622 419 patients, of whom 36\u2009802 had a cancer diagnosis and 28\u2009857 died without a cancer diagnosis within 12 months of the index.<\/jats:p>\n                    <jats:p>The risk of specific cancers exceeded the UK urgent referral risk threshold of 3% from a relatively young age for patients with red flag symptoms. For non-organ-specific symptoms, the risk of cancer at individual sites either did not reach the threshold at any age or reached it only in older patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with new-onset symptoms in primary care often have comparable risks of cancer diagnosis and non-cancer mortality. Non-organ-specific symptoms, in particular, are associated with elevated risk of cancer at multiple different sites. Management of symptomatic patients in primary care should be informed by the risk of different cancer types alongside mortality risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjonc-2024-000500","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T02:34:02Z","timestamp":1732242842000},"page":"e000500","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Cancer incidence and competing mortality risk following 15 presenting symptoms in primary care: a population-based cohort study using electronic healthcare records"],"prefix":"10.1136","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1148-1922","authenticated-orcid":false,"given":"Matthew E","family":"Barclay","sequence":"first","affiliation":[{"name":"Department of Behavioural Science and Health, Institute of Epidemiology and Healthcare, University College London, London, 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Medicine, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Lange","sequence":"additional","affiliation":[{"name":"Cancer Early Detection Advanced Research Center, Oregon Health & Science University, Portland, Oregon, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0843-2468","authenticated-orcid":false,"given":"Nora","family":"Pashayan","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK"},{"name":"Department of Applied Health Research, Institute of Epidemiology and Healthcare, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9612-7791","authenticated-orcid":false,"given":"Spiros","family":"Denaxas","sequence":"additional","affiliation":[{"name":"Institute of Health 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