{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:35:08Z","timestamp":1787654108346,"version":"build-2736575974"},"reference-count":83,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"unspecified","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["bmjonc"],"accepted":{"date-parts":[[2025,2,17]]},"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of this study was to determine the impact of margin width and boost radiotherapy on the local recurrence risk of pure ductal carcinoma in situ (DCIS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>This is a prospectively registered systematic review and meta-analysis reporting relative risk (RR), OR and HR margin width outcomes. Eligible studies included prospective and retrospective case series with defining margin widths and 48 months of minimum follow-up. All patients (100%) received adjuvant whole breast radiotherapy (WBRT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 40 265 patients with pure DCIS in 31 studies were included. ORs and RR were calculated from 15 studies in 12 519 patients, and HRs were calculated from 12 studies in 12 946 patients. Local recurrence was significantly greater with narrower \u2018close\u2019 margins; 0.1\u20131 mm versus &gt;1 mm in RR (2.88, 95% CI 1.86 to 3.90; p&lt;0.05), OR (4.82, 95% CI 2.45 to 9.48; p&lt;0.05) and HR analysis (1.34, 95% CI 1.01 to 1.67; p&lt;0.05). Compared with margins &gt;2 mm, significantly greater local recurrence was observed in margins 0.1\u20132 mm in RR (1.72, 95% CI 1.09 to 2.35; p&lt;0.05) and OR (4.43, 95% CI 3.02 to 6.50; p&lt;0.05). Comparing 0.1\u20131 mm versus &gt;1 mm and 0.1\u20132 mm versus &gt;2 mm, differences in local recurrence were not statistically significant, once adjusted for boost radiotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In pure DCIS with WBRT, the local recurrence risk reduces as margin width increases up to 2 mm. The strength of the recommendation for a minimum clear margin of 2 mm is limited by a lack of data comparing 1.1\u20132 mm with &gt;2 mm. The association between recurrence and close margins is not significant following boost radiotherapy, suggesting a possible alternative to re-excision in patients with close margins &lt;2 mm.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Systematic review registration<\/jats:title>\n                  <jats:p>CRD42022308524.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjonc-2024-000633","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T07:06:50Z","timestamp":1741331210000},"page":"e000633","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of resection margin width on local recurrence following breast-conserving surgery and whole breast radiotherapy for pure ductal carcinoma in situ: a systematic review and meta-analysis"],"prefix":"10.1136","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9065-5179","authenticated-orcid":false,"given":"Ahmed","family":"Ezzat","sequence":"first","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"},{"name":"Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhurka","family":"Shanthakumar","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Laskar","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"},{"name":"Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1719-7255","authenticated-orcid":false,"given":"Ramsey I","family":"Cutress","sequence":"additional","affiliation":[{"name":"University Hospital Southampton NHS Foundation Trust, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Hadjiminas","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"},{"name":"Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Boland","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"},{"name":"Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronak","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Amalina Che","family":"Bakri","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saur","family":"Hajev","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Elghazaly","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Holt","sequence":"additional","affiliation":[{"name":"Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfie","family":"Roddan","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Cleator","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"},{"name":"Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ara","family":"Darzi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-0672","authenticated-orcid":false,"given":"Hutan","family":"Ashrafian","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R","family":"Leff","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, London, UK"},{"name":"Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"2025090109212732000_4.1.e000633.1","unstructured":"American Cancer Society . Cancer facts and figures 2024. Available: https:\/\/www.cancer.org\/content\/dam\/cancer-org\/research\/cancer-facts-and-statistics\/annual-cancer-facts-and-figures\/2024\/2024-cancer-facts-and-figures-acs.pdf [Accessed 2 Dec 2024]."},{"key":"2025090109212732000_4.1.e000633.2","unstructured":"Cancer Research UK . Ductal carcinoma in situ (DCIS). 2023. Available: https:\/\/www.cancerresearchuk.org\/about-cancer\/breast-cancer\/types\/ductal-carcinoma-in-situ-dcis [Accessed 10 Dec 2024]."},{"key":"2025090109212732000_4.1.e000633.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0478-6"},{"key":"2025090109212732000_4.1.e000633.4","unstructured":"Netherlands comprehensive cancer organisation (iknl). 2023. Available: https:\/\/nkr-cijfers.iknl.nl\/viewer\/incidentie-per-jaar?language=en_GB&viewerId=b814ee10-e6a5-495b-aab1-8e31799ad248 [Accessed 10 Dec 2024]."},{"key":"2025090109212732000_4.1.e000633.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.06.027"},{"key":"2025090109212732000_4.1.e000633.6","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.17124","article-title":"Association of a Diagnosis of Ductal Carcinoma In Situ With Death From Breast Cancer","volume":"3","author":"Giannakeas","year":"2020","journal-title":"JAMA Netw Open"},{"key":"2025090109212732000_4.1.e000633.7","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5446-2"},{"key":"2025090109212732000_4.1.e000633.8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.07.137"},{"key":"2025090109212732000_4.1.e000633.9","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs142"},{"key":"2025090109212732000_4.1.e000633.10","unstructured":"Surveillance, epidemiology, and end results program. 2024. Available: https:\/\/seer.cancer.gov\/statfacts\/html\/breast.html [Accessed 1 Sep 2024]."},{"key":"2025090109212732000_4.1.e000633.11","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv263","article-title":"Trends in Treatment Patterns and Outcomes for Ductal Carcinoma In Situ","volume":"107","author":"Worni","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"2025090109212732000_4.1.e000633.12","unstructured":"National Institute for Health and Care Excellence (NICE) . Early and locally advanced breast cancer: diagnosis and management. 2018. Available: https:\/\/www.nice.org.uk\/guidance\/ng101\/evidence\/evidence-review-a-surgery-to-the-breast-pdf-4904666606 [Accessed 1 Sep 2024]."},{"key":"2025090109212732000_4.1.e000633.13","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1200\/JCO.2016.68.3573","article-title":"Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma In Situ","volume":"34","author":"Morrow","year":"2016","journal-title":"J Clin Oncol"},{"key":"2025090109212732000_4.1.e000633.14","unstructured":"Association of breast surgery recommendations for the management of radial surgical margins in patients undergoing breast conserving surgery for ductal carcinoma in situ (dcis). 2024. Available: https:\/\/associationofbreastsurgery.org.uk\/media\/3z5bk0nj\/dcis-margins-guidance-2024-v2.pdf"},{"key":"2025090109212732000_4.1.e000633.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.11.016"},{"key":"2025090109212732000_4.1.e000633.16","unstructured":"Association of breast surgery consensus statement: margin width in breast conservation surgery 2015. Available: https:\/\/associationofbreastsurgery.org.uk\/media\/64245\/final-margins-consensus-statement.pdf [Accessed 10 Dec 2024]."},{"key":"2025090109212732000_4.1.e000633.17","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/j.ejso.2017.08.003","article-title":"Margin width and local recurrence after breast conserving surgery for ductal carcinoma in situ","volume":"43","author":"Ekatah","year":"2017","journal-title":"Eur J Surg Oncol"},{"key":"2025090109212732000_4.1.e000633.18","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-5067-1"},{"key":"2025090109212732000_4.1.e000633.19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.breast.2018.07.007","article-title":"Breast-conserving therapy for primary Ductal Carcinoma in Situ in The Netherlands: A multi-center study and population-based analysis","volume":"42","author":"Jobsen","year":"2018","journal-title":"Breast"},{"key":"2025090109212732000_4.1.e000633.20","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1080\/08941939.2018.1539791","article-title":"Does a Close Surgical Margin for Ductal Carcinoma In Situ Associated with Invasive Breast Carcinoma Affect Breast Cancer Recurrence?","volume":"33","author":"Kuru","year":"2020","journal-title":"J Invest Surg"},{"key":"2025090109212732000_4.1.e000633.21","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10549-021-06278-5","article-title":"Does margin width impact breast cancer recurrence rates in women with breast conserving surgery for ductal carcinoma in situ?","volume":"189","author":"Livingston-Rosanoff","year":"2021","journal-title":"Breast Cancer Res Treat"},{"key":"2025090109212732000_4.1.e000633.22","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.m1570","article-title":"Invasive breast cancer and breast cancer mortality after ductal carcinoma in situ in women attending for breast screening in England, 1988-2014: population based observational cohort study","volume":"369","author":"Mannu","year":"2020","journal-title":"BMJ"},{"key":"2025090109212732000_4.1.e000633.23","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-076022","article-title":"Association of DCIS size and margin status with risk of developing breast cancer post-treatment: multinational, pooled cohort study","volume":"383","author":"Schmitz","year":"2023","journal-title":"BMJ"},{"key":"2025090109212732000_4.1.e000633.24","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.clbc.2016.02.002","article-title":"Importance of Surgical Margin Status in Ductal Carcinoma In Situ","volume":"16","author":"Shaikh","year":"2016","journal-title":"Clin Breast Cancer"},{"key":"2025090109212732000_4.1.e000633.25","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001454"},{"key":"2025090109212732000_4.1.e000633.26","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1016\/S0140-6736(24)00425-2","article-title":"Ductal carcinoma in situ of the breast: finding the balance between overtreatment and undertreatment","volume":"403","author":"Delaloge","year":"2024","journal-title":"Lancet"},{"key":"2025090109212732000_4.1.e000633.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01246-6"},{"key":"2025090109212732000_4.1.e000633.28","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.ejso.2013.03.002","article-title":"Role of radiotherapy boost in women with ductal carcinoma in situ: A single-center experience in a series of 389 patients","volume":"39","author":"Meattini","year":"2013","journal-title":"European Journal of Surgical Oncology (EJSO)"},{"key":"2025090109212732000_4.1.e000633.29","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1001\/jamaoncol.2016.6948","article-title":"Association of Radiotherapy Boost for Ductal Carcinoma In Situ With Local Control After Whole-Breast Radiotherapy","volume":"3","author":"Moran","year":"2017","journal-title":"JAMA Oncol"},{"key":"2025090109212732000_4.1.e000633.30","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70765-3"},{"key":"2025090109212732000_4.1.e000633.31","article-title":"What\u2019s the Risk: Differentiating Risk Ratios, Odds Ratios, and Hazard Ratios?","volume":"12","author":"George","year":"2020","journal-title":"Cureus"},{"key":"2025090109212732000_4.1.e000633.32","doi-asserted-by":"crossref","unstructured":"McKenzie DP , Thomas C . Relative risks and odds ratios: Simple rules on when and how to use them. Eur J Clin Invest 2020.:e13249. doi:10.1111\/eci.13249","DOI":"10.1111\/eci.13249"},{"key":"2025090109212732000_4.1.e000633.33","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e31817a7ee4"},{"key":"2025090109212732000_4.1.e000633.34","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"2025090109212732000_4.1.e000633.35","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"2025090109212732000_4.1.e000633.36","unstructured":"StataCrop . Stata statistical software: release 18. College Station, TX: StataCorp LLC."},{"key":"2025090109212732000_4.1.e000633.37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2007.00447.x"},{"key":"2025090109212732000_4.1.e000633.38","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.breast.2017.08.002","article-title":"Management of breast ductal carcinoma in situ in Catalonia, Spain: Results from the Grup Oncologic Calal\u00e0-Occit\u00e0-Catalonia survey with 9-year follow up","volume":"35","author":"Cambra","year":"2017","journal-title":"Breast"},{"key":"2025090109212732000_4.1.e000633.39","first-page":"17","article-title":"Ductal carcinoma in situ of the breast - Long term results from a twenty-year cohort","volume":"14","author":"Co","year":"2018","journal-title":"Cancer Treat Res Commun"},{"key":"2025090109212732000_4.1.e000633.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00303-3"},{"key":"2025090109212732000_4.1.e000633.41","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq499"},{"key":"2025090109212732000_4.1.e000633.42","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950315)75:6<1310::AID-CNCR2820750613>3.0.CO;2-G"},{"key":"2025090109212732000_4.1.e000633.43","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00153-3"},{"key":"2025090109212732000_4.1.e000633.44","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.1366"},{"key":"2025090109212732000_4.1.e000633.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.08.015"},{"key":"2025090109212732000_4.1.e000633.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.08.026"},{"key":"2025090109212732000_4.1.e000633.47","doi-asserted-by":"crossref","first-page":"327","DOI":"10.4048\/jbc.2017.20.4.327","article-title":"Selective Radiation Therapy for Ductal Carcinoma In Situ Following Breast-Conserving Surgery According to Age and Margin Width: Korean Radiation Oncology Group 11-04 and 16-02 Studies","volume":"20","author":"Kim","year":"2017","journal-title":"J Breast Cancer"},{"key":"2025090109212732000_4.1.e000633.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2006.06.031"},{"key":"2025090109212732000_4.1.e000633.49","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.breast.2016.11.002","article-title":"Factors influencing local control in patients undergoing breast conservation surgery for ductal carcinoma in situ","volume":"31","author":"Mathew","year":"2017","journal-title":"Breast"},{"key":"2025090109212732000_4.1.e000633.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.12.014"},{"key":"2025090109212732000_4.1.e000633.51","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b5931e"},{"key":"2025090109212732000_4.1.e000633.52","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrv034"},{"key":"2025090109212732000_4.1.e000633.53","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20886"},{"key":"2025090109212732000_4.1.e000633.54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/PPO.0000000000000025","article-title":"Local relapse after breast-conserving therapy for ductal carcinoma in situ: a European single-center experience and external validation of the Memorial Sloan-Kettering Cancer Center DCIS nomogram","volume":"20","author":"Sweldens","year":"2014","journal-title":"Cancer J"},{"key":"2025090109212732000_4.1.e000633.55","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21284"},{"key":"2025090109212732000_4.1.e000633.56","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s12282-014-0531-5","article-title":"Epidemiology of ductal carcinoma in situ in Western Australia: implications for surgical margins and management","volume":"22","author":"Butler-Henderson","year":"2015","journal-title":"Breast Cancer"},{"key":"2025090109212732000_4.1.e000633.57","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13134"},{"key":"2025090109212732000_4.1.e000633.58","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10357"},{"key":"2025090109212732000_4.1.e000633.59","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905133401902"},{"key":"2025090109212732000_4.1.e000633.60","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01517-6"},{"key":"2025090109212732000_4.1.e000633.61","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0959-8049(02)00774-8","article-title":"Immunohistochemical study of cell cycle regulatory proteins in intraductal breast carcinomas--a preliminary study","volume":"39","author":"Chasle","year":"2003","journal-title":"Eur J Cancer"},{"key":"2025090109212732000_4.1.e000633.62","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr027"},{"key":"2025090109212732000_4.1.e000633.63","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1001\/jamaoncol.2015.2510","article-title":"Breast Cancer Mortality After a Diagnosis of Ductal Carcinoma In Situ","volume":"1","author":"Narod","year":"2015","journal-title":"JAMA Oncol"},{"key":"2025090109212732000_4.1.e000633.64","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.5182"},{"key":"2025090109212732000_4.1.e000633.65","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90747-S"},{"key":"2025090109212732000_4.1.e000633.66","first-page":"193","article-title":"Three dimensional imaging of mammary ductal carcinoma in situ: clinical implications","volume":"11","author":"Faverly","year":"1994","journal-title":"Semin Diagn Pathol"},{"key":"2025090109212732000_4.1.e000633.67","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.9975"},{"key":"2025090109212732000_4.1.e000633.68","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ejca.2017.07.032","article-title":"Current margin practice and effect on re-excision rates following the publication of the SSO-ASTRO consensus and ABS consensus guidelines: a national prospective study of 2858 women undergoing breast-conserving therapy in the UK and Ireland","volume":"84","author":"Tang","year":"2017","journal-title":"Eur J Cancer"},{"key":"2025090109212732000_4.1.e000633.69","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10549-021-06187-7","article-title":"DUCHESS: an evaluation of the ductal carcinoma in situ score for decisions on radiotherapy in patients with low\/intermediate-risk DCIS","volume":"188","author":"Rakovitch","year":"2021","journal-title":"Breast Cancer Res Treat"},{"key":"2025090109212732000_4.1.e000633.70","first-page":"507","article-title":"Radiation treatment for ductal carcinoma in situ (DCIS): is a boost to the tumor bed necessary?","volume":"53","author":"Yerushalmi","year":"2006","journal-title":"Neoplasma"},{"key":"2025090109212732000_4.1.e000633.71","doi-asserted-by":"crossref","first-page":"101254","DOI":"10.1016\/j.adro.2023.101254","article-title":"Locoregional Control Benefit of a Tumor Bed Boost for Ductal Carcinoma In Situ","volume":"8","author":"Dreyfuss","year":"2023","journal-title":"Adv Radiat Oncol"},{"key":"2025090109212732000_4.1.e000633.72","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-2-28"},{"key":"2025090109212732000_4.1.e000633.73","doi-asserted-by":"crossref","first-page":"103584","DOI":"10.1016\/j.breast.2023.103584","article-title":"The King is in the altogether: Radiation therapy after oncoplastic breast surgery","volume":"72","author":"Kaidar-Person","year":"2023","journal-title":"Breast"},{"key":"2025090109212732000_4.1.e000633.74","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1245\/s10434-023-13592-3","article-title":"The Impact of Breast-Conserving Surgery Re-excision on Patient-Reported Outcomes Using the BREAST-Q","volume":"30","author":"Matar-Ujvary","year":"2023","journal-title":"Ann Surg Oncol"},{"key":"2025090109212732000_4.1.e000633.75","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71156-8"},{"key":"2025090109212732000_4.1.e000633.76","article-title":"Tumour bed boost radiotherapy for women after breast-conserving surgery","volume":"11","author":"Kindts","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"2025090109212732000_4.1.e000633.77","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.07.032"},{"key":"2025090109212732000_4.1.e000633.78","doi-asserted-by":"crossref","DOI":"10.1001\/jamasurg.2022.0631","article-title":"Long-term Quality of Life in Patients With Breast Cancer After Breast Conservation vs Mastectomy and Reconstruction","volume":"157","author":"Hanson","year":"2022","journal-title":"JAMA Surg"},{"key":"2025090109212732000_4.1.e000633.79","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1245\/s10434-021-11293-3","article-title":"Mastectomy or Margin Re-excision? A Nomogram for Close\/Positive Margins After Lumpectomy for DCIS","volume":"29","author":"Martins Maia","year":"2022","journal-title":"Ann Surg Oncol"},{"key":"2025090109212732000_4.1.e000633.80","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.1100","article-title":"Association of Radiotherapy With Survival in Women Treated for Ductal Carcinoma In Situ With Lumpectomy or Mastectomy","volume":"1","author":"Giannakeas","year":"2018","journal-title":"JAMA Netw Open"},{"key":"2025090109212732000_4.1.e000633.81","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-075498","article-title":"Invasive breast cancer and breast cancer death after non-screen detected ductal carcinoma in situ from 1990 to 2018 in England: population based cohort study","volume":"384","author":"Mannu","year":"2024","journal-title":"BMJ"},{"key":"2025090109212732000_4.1.e000633.82","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603945"},{"key":"2025090109212732000_4.1.e000633.83","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-4693-2"}],"container-title":["BMJ Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjonc-2024-000633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T16:21:40Z","timestamp":1756743700000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjoncology.bmj.com\/lookup\/doi\/10.1136\/bmjonc-2024-000633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":83,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,3,6]]},"published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1136\/bmjonc-2024-000633"],"URL":"https:\/\/doi.org\/10.1136\/bmjonc-2024-000633","relation":{},"ISSN":["2752-7948"],"issn-type":[{"value":"2752-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}