{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:23:45Z","timestamp":1770434625626,"version":"3.49.0"},"reference-count":26,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2011,12,12]]},"published-print":{"date-parts":[[2012]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate if \u2018wrap therapy\u2019 using food wraps, which is widely used in Japanese clinical sites, is not inferior when compared to guideline adhesion treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Multicentre, prospective, randomised, open, blinded endpoint clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>15 hospitals in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>66 older patients with new National Pressure Ulcer Advisory Panel stage II or III pressure ulcers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Of these 66 patients, 31 were divided into the conventional treatment guidelines group and 35 into the wrap therapy group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>The primary end point was the period until the pressure ulcers were cured. The secondary end point was a comparison of the speed of change in the Pressure Ulcer Scale for Healing score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>64 of the 66 patients were analysed. The estimated mean period until healing was 57.5\u2005days (95% CI 45.2 to 69.8) in the control group as opposed to 59.8\u2005days (95% CI 49.7 to 69.9) in the wrap therapy group. By the extent of pressure ulcer infiltration, the mean period until healing was 16.0\u2005days (95% CI 8.1 to 23.9) in the control group as opposed to 18.8\u2005days (95% CI 10.3 to 27.2) in the wrap therapy group with National Pressure Ulcer Advisory Panel stage II ulcers, and 71.8\u2005days (95% CI 61.4 to 82.3) as opposed to 63.2\u2005days (95% CI 53.0 to 73.4), respectively, with stage III ulcers. There is no statistical significance in difference in Pressure Ulcer Scale for Healing scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It might be possible to consider wrap therapy as an alternative choice in primary care settings as a simple and inexpensive dressing care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial registration<\/jats:title>\n                    <jats:p>\n                      UMIN Clinical Trials Registry UMIN000002658. Summary protocol is available on\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/upload.umin.ac.jp\/cgi-bin\/ctr\/ctr.cgi?function=brows%26action=brows%26type=detail%26recptno=R000003235%26admin=0%26language=J\">https:\/\/upload.umin.ac.jp\/cgi-bin\/ctr\/ctr.cgi?function=brows&amp;action=brows&amp;type=detail&amp;recptno=R000003235&amp;admin=0&amp;language=J<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2011-000371","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T06:10:06Z","timestamp":1325830206000},"page":"e000371","source":"Crossref","is-referenced-by-count":10,"title":["Randomised controlled trial evaluating the efficacy of wrap therapy for wound healing acceleration in patients with NPUAP stage II and III pressure ulcer"],"prefix":"10.1136","volume":"2","author":[{"given":"Seiji","family":"Bito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Mizuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandai","family":"Oonishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsune","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyo","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,1,5]]},"reference":[{"issue":"1A Suppl","key":"2025121512382791000_2.1.e000371.1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0002-9610(03)00285-X","article-title":"Protocol for the successful treatment of pressure ulcers","volume":"188","author":"Brem","year":"2004","journal-title":"Am J Surg"},{"key":"2025121512382791000_2.1.e000371.2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.16482"},{"key":"2025121512382791000_2.1.e000371.3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.7326\/0003-4819-123-6-199509150-00008","article-title":"Pressure ulcers in the nursing home","volume":"123","author":"Smith","year":"1995","journal-title":"Ann Intern Med"},{"key":"2025121512382791000_2.1.e000371.4","first-page":"1","volume-title":"Pressure ulcer treatment: Clinical Practice Guideline Quick Reference Guide","volume":"15","author":"Agency for Health Care Policy and Research","year":"1994"},{"key":"2025121512382791000_2.1.e000371.5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta5090","article-title":"Systematic reviews of wound care management: (5) beds; (6) compression; (7) laser therapy, therapeutic ultrasound, electrotherapy and electromagnetic therapy","volume":"5","author":"Cullum","year":"2001","journal-title":"Health Technol Assess"},{"key":"2025121512382791000_2.1.e000371.6","doi-asserted-by":"crossref","unstructured":"McInnes E Bell-Syer SE Dumville JC . 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