{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T09:58:49Z","timestamp":1772099929191,"version":"3.50.1"},"reference-count":26,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2012,6,26]]},"published-print":{"date-parts":[[2012]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the 24\u2005h effects of bimatoprost 0.01% monotherapy on intraocular pressure (IOP) and ocular perfusion pressure (OPP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective, open-label experimental study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single tertiary ophthalmic clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Sixteen patients with diagnosed primary open-angle glaucoma (POAG) or ocular hypertension (ages, 49\u201377\u2005years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Baseline data of 24\u2005h IOP in untreated patients were collected in a sleep laboratory. Measurements of IOP were taken using a pneumatonometer every 2\u2005h in the sitting and supine body positions during the 16\u2005h diurnal\/wake period and in the supine position during the 8\u2005h nocturnal\/sleep period. After baseline measurements were taken, patients were treated with bimatoprost 0.01% one time per day at bedtime for 4\u2005weeks, and then 24\u2005h IOP data were collected under the same laboratory conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Diurnal and nocturnal IOP and OPP means under bimatoprost 0.01% treatment were compared with baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The diurnal and nocturnal IOP means were significantly lower under the bimatoprost 0.01% treatment than baseline in both the sitting and supine positions. The diurnal and nocturnal OPP means were significantly higher under treatment than baseline in both the sitting and supine positions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bimatoprost 0.01% monotherapy significantly lowered IOP and increased OPP during the 24\u2005h period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2012-001106","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T21:17:28Z","timestamp":1345756648000},"page":"e001106","source":"Crossref","is-referenced-by-count":17,"title":["Twenty-four-hour effects of bimatoprost 0.01% monotherapy on intraocular pressure and ocular perfusion pressure"],"prefix":"10.1136","volume":"2","author":[{"given":"Jonathan D","family":"Tung","sequence":"first","affiliation":[{"name":"Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Tafreshi","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert N","family":"Weinreb","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Rigby","family":"Slight","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe A","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H K","family":"Liu","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,8,23]]},"reference":[{"key":"2025121220454850000_2.4.e001106.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16257-0"},{"key":"2025121220454850000_2.4.e001106.2","unstructured":"Weinreb RN Harris A . 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