{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:58:09Z","timestamp":1765605489820,"version":"3.48.0"},"reference-count":18,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2012,10,15]]},"published-print":{"date-parts":[[2012]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate if the use of antitransglutaminase (tTG) and antiendomysium (EM) antibodies has modified the profile of coeliac disease (CD) in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Monocentric study, in one major tertiary centre in Paris. Two cohorts of patients were compared; the first included patients before the use of antibodies, and the second included patients after the use of antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>All patients from the same physician diagnosed with a CD between 1976 and 1992 (historical cohort), and between 1994 and 2007, were included in the study. 56 patients were included in the historical cohort, 59 in the recent cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Clinical, biological and histological profiles at diagnosis have been studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The recent cohort diagnosis of CD was based in 27% on a systematic screening (type I diabetes, n=10; CD in siblings, n=6). On comparison of CD patients in the historical to the recent cohort, the following significant differences were observed: Median age at diagnosis increased from 1\u2005year to 2.7\u2005years (p&lt;0.0001). Patients in the historical cohort had more gastrointestinal symptoms (93% vs 63%, p=0.0001) and failure to thrive (98% vs 80%, p=0.0025). Nutritional deficiencies and morphological lesions were more severe in the historical cohort (90% subtotal or total villous atrophy vs 51%, p&lt;0.0001). Differences observed between the two cohorts were mainly due to the presence of screened patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A new type of patients, with a paucisymptomatic or asymptomatic CD, has been identified using serological tests. Silent disease has been diagnosed by screening in a target population. In the other patients of the recent cohort, symptoms were similar but less severe than those observed before. Long-term risks of untreated silent CD are not well determined as yet, and have to be evaluated in prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2012-001385","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T20:26:36Z","timestamp":1353702396000},"page":"e001385","source":"Crossref","is-referenced-by-count":4,"title":["Have serological tests changed the face of childhood coeliac disease? A retrospective cohort study"],"prefix":"10.1136","volume":"2","author":[{"given":"H\u00e9l\u00e8ne","family":"Garnier-Lenglin\u00e9","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology Unit, H\u00f4pital Necker-Enfants Malades, Paris, France"},{"name":"INSERM U989, Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Brousse","sequence":"additional","affiliation":[{"name":"Department of Pathology, H\u00f4pital Necker-Enfants Malades, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Candon","sequence":"additional","affiliation":[{"name":"Department of Immunology, H\u00f4pital Necker-Enfants Malades, Paris, France"},{"name":"INSERM U580, H\u00f4pital Necker-Enfants Malades, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Goulet","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit, H\u00f4pital Necker-Enfants Malades, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank M","family":"Ruemmele","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit, H\u00f4pital Necker-Enfants Malades, Paris, France"},{"name":"INSERM U989, Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit, H\u00f4pital Necker-Enfants Malades, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,11,22]]},"reference":[{"key":"2025121221563811000_2.6.e001385.1","first-page":"181","article-title":"Antigliadin, antireticulin, antiendomysium antibodies: value in the diagnosis and follow-up of celiac disease in children","volume":"1","author":"Olives","year":"1994","journal-title":"Arch Pediatr"},{"key":"2025121221563811000_2.6.e001385.2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.028"},{"key":"2025121221563811000_2.6.e001385.3","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199701000-00006"},{"key":"2025121221563811000_2.6.e001385.4","first-page":"107","article-title":"Incidence de la maladie coeliaque symptomatique de l'enfant en France","volume":"30","author":"Baudon","year":"2001","journal-title":"Presse Med"},{"key":"2025121221563811000_2.6.e001385.5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.10.004"},{"key":"2025121221563811000_2.6.e001385.6","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1651-2227.1988.tb10668.x","article-title":"Changing pattern of childhood coeliac disease in Finland","volume":"77","author":"Maki","year":"1988","journal-title":"Acta Paediatr Scand"},{"key":"2025121221563811000_2.6.e001385.7","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1651-2227.1991.tb11901.x","article-title":"Changing pattern of coeliac disease in western Toscana","volume":"80","author":"Ceccarelli","year":"1991","journal-title":"Acta Paediatr Scand"},{"key":"2025121221563811000_2.6.e001385.8","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(99)00243-3","article-title":"An iceberg of childhood coeliac disease in the Netherlands","volume":"353","author":"Csizmadia","year":"1999","journal-title":"Lancet"},{"key":"2025121221563811000_2.6.e001385.9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2373"},{"key":"2025121221563811000_2.6.e001385.10","doi-asserted-by":"crossref","unstructured":"Rossipal E . 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Lancaster: MTP Press, 1981: 19\u201322.","DOI":"10.1007\/978-94-011-8114-3_4"},{"key":"2025121221563811000_2.6.e001385.12","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36585"},{"key":"2025121221563811000_2.6.e001385.13","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.9.1215"},{"key":"2025121221563811000_2.6.e001385.14","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510012181"},{"key":"2025121221563811000_2.6.e001385.15","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1999.0029900297"},{"key":"2025121221563811000_2.6.e001385.16","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.219030"},{"key":"2025121221563811000_2.6.e001385.17","first-page":"181","article-title":"Symptoms and signs have changed in Swedish children with coeliac disease","volume":"38","author":"Ludvigsson","year":"2004","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2025121221563811000_2.6.e001385.18","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1136\/adc.2006.094045","article-title":"The changing clinical presentation of coeliac disease","volume":"91","author":"Ravikumara","year":"2006","journal-title":"Arch Dis Child"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2012-001385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:56:46Z","timestamp":1765605406000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2012-001385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,11,22]]},"published-print":{"date-parts":[[2012]]}},"alternative-id":["10.1136\/bmjopen-2012-001385"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2012-001385","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2012]]}}}