{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:01:52Z","timestamp":1787508112414,"version":"build-2736575974"},"reference-count":49,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2012,10,2]]},"published-print":{"date-parts":[[2012]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Epidemiological studies indicate that significant decreases in the incidence of Alzheimer's disease (AD) may be obtained by targeting multiple middle-age risk factors. However, as dementia is unlikely to be diagnosed for decades, short-term outcome measures are required. AD biomarker changes precede clinical symptoms by many years, but their sensitivity to mid-life change remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>PREVENT is a prospective cohort study examining biomarker status at mid-life in at least 150 individuals genetically at high, medium or low risk of late-onset AD. Participants are children of individuals with or without a diagnosed AD allocated to high, medium and low-risk groups according to parental clinical status and ApoE genotype. The biomarkers examined over 2\u2005years are plasma and CSF A\u03b242 amyloid, Tau and pTau, proinflammatory cytokines, acute-phase proteins, medial temporal-lobe atrophy, white matter lesion volume, cognitive performance related to transentorhinal and hippocampal functioning and hypothalamic\u2212pituitary\u2212adrenal and sympathetic axes regulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Detected pathologies are communicated to the participant's general practitioner with their permission. Risk status by genotype would not be revealed. The results of the study would be published in peer-reviewed journals and validated biomarkers used to construct a randomised controlled intervention study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2012-001893","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T20:56:12Z","timestamp":1353358572000},"page":"e001893","source":"Crossref","is-referenced-by-count":117,"title":["The PREVENT study: a prospective cohort study to identify mid-life biomarkers of late-onset Alzheimer's disease"],"prefix":"10.1136","volume":"2","author":[{"given":"Craig W","family":"Ritchie","sequence":"first","affiliation":[{"name":"Centre for Mental Health, Imperial College London, London, UK"},{"name":"West London Mental Health Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Neuroepidemiology of Ageing Research Unit, Imperial College, London, UK"},{"name":"U1061 Neuropsychiatry, Inserm, Montpellier, France"},{"name":"Universit\u00e9 de Montpellier 1, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,11,19]]},"reference":[{"key":"2025120518461847000_2.6.e001893.1","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/S0140-6736(05)67889-0","article-title":"Global prevalence of dementia: a Delphi consensus study","volume":"17","author":"Ferri","year":"2005","journal-title":"Lancet"},{"key":"2025120518461847000_2.6.e001893.2","doi-asserted-by":"crossref","unstructured":"Barnes DE Yaffe K . 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