{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T19:09:18Z","timestamp":1787252958692,"version":"build-2736575974"},"reference-count":30,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2012,11,14]]},"published-print":{"date-parts":[[2012]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Evaluate the validity of the\n                      <jats:italic>International Classification of Diseases, 10th revision<\/jats:italic>\n                      (ICD-10) code for hyperkalaemia (E87.5) in two settings: at presentation to an emergency department and at hospital admission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Population-based validation study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>12 hospitals in Southwestern Ontario, Canada, from 2003 to 2010.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Elderly patients with serum potassium values at presentation to an emergency department (n=64\u2005579) and at hospital admission (n=64\u2005497).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary outcome<\/jats:title>\n                    <jats:p>Sensitivity, specificity, positive-predictive value and negative-predictive value. Serum potassium values in patients with and without a hyperkalaemia code (code positive and code negative, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The sensitivity of the best-performing ICD-10 coding algorithm for hyperkalaemia (defined by serum potassium &gt;5.5\u2005mmol\/l) was 14.1% (95% CI 12.5% to 15.9%) at presentation to an emergency department and 14.6% (95% CI 13.3% to 16.1%) at hospital admission. Both specificities were greater than 99%. In the two settings, the positive-predictive values were 83.2% (95% CI 78.4% to 87.1%) and 62.0% (95% CI 57.9% to 66.0%), while the negative-predictive values were 97.8% (95% CI 97.6% to 97.9%) and 96.9% (95% CI 96.8% to 97.1%). In patients who were code positive for hyperkalaemia, median (IQR) serum potassium values were 6.1 (5.7 to 6.8)\u2005mmol\/l at presentation to an emergency department and 6.0 (5.1 to 6.7) mmol\/l at hospital admission. For code-negative patients median (IQR) serum potassium values were 4.0 (3.7 to 4.4) mmol\/l and 4.1 (3.8 to 4.5) mmol\/l in each of the two settings, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with hospital encounters who were ICD-10 E87.5 hyperkalaemia code positive and negative had distinct higher and lower serum potassium values, respectively. However, due to very low sensitivity, the incidence of hyperkalaemia is underestimated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2012-002011","type":"journal-article","created":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T22:07:42Z","timestamp":1356732462000},"page":"e002011","source":"Crossref","is-referenced-by-count":59,"title":["Validity of the\n                    <i>International Classification of Diseases 10th revision<\/i>\n                    code for hyperkalaemia in elderly patients at presentation to an emergency department and at hospital admission"],"prefix":"10.1136","volume":"2","author":[{"given":"Jamie L","family":"Fleet","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Western University, London, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salimah Z","family":"Shariff","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Western University, London, Canada"},{"name":"Department of Epidemiology & Biostatistics, Western University, London, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A","family":"Weir","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Western University, London, Canada"},{"name":"Department of Epidemiology & Biostatistics, Western University, London, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsh K","family":"Jain","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Western University, London, Canada"},{"name":"Institute for Clinical Evaluative Sciences, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit X","family":"Garg","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Western University, London, Canada"},{"name":"Institute for Clinical Evaluative Sciences, Toronto, Canada"},{"name":"Department of Epidemiology & Biostatistics, Western University, London, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,12,28]]},"reference":[{"key":"2025121513482646000_2.6.e002011.1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199801000-00004"},{"key":"2025121513482646000_2.6.e002011.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2005.03.016"},{"key":"2025121513482646000_2.6.e002011.3","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.100461"},{"key":"2025121513482646000_2.6.e002011.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra035279"},{"key":"2025121513482646000_2.6.e002011.5","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.1.26"},{"key":"2025121513482646000_2.6.e002011.6","unstructured":"World Health Organization. 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