{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T08:55:55Z","timestamp":1776934555323,"version":"3.51.2"},"reference-count":39,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2013,1,24]]},"published-print":{"date-parts":[[2013]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify patient characteristics and surgical factors associated with patient-reported outcomes over 5\u2005years following primary total hip replacement (THR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Seven hospitals across England and Scotland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>1431 primary hip replacements for osteoarthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>The Oxford Hip Score (OHS) was collected preoperatively and each year up to 5\u2005years postoperatively. Repeated measures such as linear regression modelling are used to identify patient and surgical predictors of outcome and describe trends over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The majority of patients demonstrated substantial improvement in pain\/function in the first year after surgery\u2014between 1 and 5\u2005years follow-up, there was neither further improvement nor decline. The strongest determinant of attained postoperative OHS was the preoperative OHS\u2014those with worse preoperative pain\/function had worse postoperative pain\/function. Other predictors with small but significant effects included: femoral component offset\u2014women with an offset of 44 or more had better outcomes; age\u2014compared to those aged 50\u201360, younger (age &lt;50) and older patients (age &gt;60) had worse outcome, increasing body mass index (BMI), more coexisting diseases and worse Short Form 36 mental health (MH) was related to worse postoperative pain\/function. Assessment of change in OHS between preoperative \u00a0and postoperative assessments revealed that patients achieved substantial and clinically relevant symptomatic improvement (change), regardless of variation in these patient and surgical factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients received substantial benefit from surgery, regardless of their preoperative assessments and surgical characteristics (baseline pain\/function, age, BMI, comorbidities, MH and femoral component offset). Further research is needed to identify other factors that can improve our ability to identify patients at risk of poor outcomes from THR surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2012-002453","type":"journal-article","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T05:23:11Z","timestamp":1362201791000},"page":"e002453","source":"Crossref","is-referenced-by-count":90,"title":["The association of patient characteristics and surgical variables on symptoms of pain and function over 5\u2005years following primary hip-replacement surgery: a prospective cohort study"],"prefix":"10.1136","volume":"3","author":[{"given":"Andy","family":"Judge","sequence":"first","affiliation":[{"name":"Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Headington, Oxford, UK"},{"name":"MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel K","family":"Arden","sequence":"additional","affiliation":[{"name":"Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Headington, Oxford, UK"},{"name":"MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajbir N","family":"Batra","sequence":"additional","affiliation":[{"name":"Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Headington, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraint","family":"Thomas","sequence":"additional","affiliation":[{"name":"Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Headington, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Beard","sequence":"additional","affiliation":[{"name":"Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Headington, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Kassim","family":"Javaid","sequence":"additional","affiliation":[{"name":"Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Headington, Oxford, UK"},{"name":"MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrus","family":"Cooper","sequence":"additional","affiliation":[{"name":"Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Headington, Oxford, UK"},{"name":"MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Murray","sequence":"additional","affiliation":[{"name":"Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Headington, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Exeter Primary Outcomes Study (EPOS) group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"2025121422094179000_3.3.e002453.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199009133231106"},{"key":"2025121422094179000_3.3.e002453.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199009203231206"},{"key":"2025121422094179000_3.3.e002453.3","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2106\/00004623-200405000-00012","article-title":"Health-related quality of life in total hip and total knee arthroplasty. 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