{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:56:22Z","timestamp":1791312982131,"version":"4.3.1"},"reference-count":76,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2013,11,11]]},"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To examine the interrelations among, and risk marker associations for, superficial and deep venous events\u2014superficial venous thrombosis (SVT), deep venous thrombosis (DVT) and pulmonary embolism (PE).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Cross-sectional analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>San Diego, California, USA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>2404 men and women aged 40\u201379\u2005years from four ethnic groups: non-Hispanic White, Hispanic, African-American and Asian. The study sample was drawn from current and former staff and employees of the University of California, San Diego and their spouses\/significant others.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcome measures<\/jats:title>\n                  <jats:p>Superficial and deep venous events, specifically SVT, DVT, PE and combined deep venous events (DVE) comprising DVT and PE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Significant correlates on multivariable analysis were, for SVT: female sex, ethnicity (African-American=protective), lower educational attainment, immobility and family history of varicose veins. For DVT and DVE, significant correlates included: heavy smoking, immobility and family history of DVEs (borderline for DVE). For PE, significant predictors included immobility and, in contrast to DVT, blood pressure (BP, systolic or diastolic). In women, oestrogen use duration for hormone replacement therapy, in all and among oestrogen users, predicted PE and DVE, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings fortify evidence for known risk correlates\/predictors for venous disease, such as family history, hormone use and immobility. New risk associations are shown. Striking among these is an association of PE, but not DVT, to elevated BP: we conjecture PE may serve as cause rather than consequence. Future studies should evaluate the temporal direction of this association. Oxidative stress and cell energy compromise are proposed to explain and predict many risk factors, operating through cell-death mediated triggering of coagulation activation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2013-003208","type":"journal-article","created":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T00:14:22Z","timestamp":1395447262000},"page":"e003208","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Risk marker associations with venous thrombotic events: a cross-sectional analysis"],"prefix":"10.1136","volume":"4","author":[{"given":"Beatrice A","family":"Golomb","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California San Diego, La Jolla, California, USA"},{"name":"Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia T","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, La Jolla, California, USA"},{"name":"Internal Medicine, Scripps Green Hospital, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie O","family":"Denenberg","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Koperski","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H","family":"Criqui","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2014,3,21]]},"reference":[{"key":"2025101815132428000_4.3.e003208.1","first-page":"118","article-title":"Varicose veins and chronic venous insufficiency","volume":"3","author":"da Silva","year":"1974","journal-title":"Vasa"},{"key":"2025101815132428000_4.3.e003208.2","first-page":"185","article-title":"[Venous disease in France: an unrecognized public health problem]","volume":"19","author":"Lafuma","year":"1994","journal-title":"J Mal Vasc"},{"key":"2025101815132428000_4.3.e003208.3","first-page":"84","article-title":"Socio-economic data on venous disease","volume":"3","author":"Daver","year":"1984","journal-title":"Int Angiol"},{"key":"2025101815132428000_4.3.e003208.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2012.06.007"},{"key":"2025101815132428000_4.3.e003208.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.07.001"},{"key":"2025101815132428000_4.3.e003208.6","first-page":"83","article-title":"Chronic venous disorders of the leg: epidemiology, outcomes, diagnosis and management. 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