{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T20:24:56Z","timestamp":1769286296352,"version":"3.49.0"},"reference-count":19,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2014,2,10]]},"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Lipodystrophy is a frequent and disfiguring adverse effect of antiretroviral therapy (ART) in patients with HIV. It affects the quality of life of the patient and adherence to treatment, and generates new needs for comprehensive healthcare services. The aim of this study will be to conduct a systematic review of the literature from observational studies and describe lipodystrophy among patients with HIV infection during current or previous use of ART.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>A systematic review of observational studies published in MEDLINE, CINAHL, LILACS, EMBASE and International Pharmaceutical Abstracts will be carried out. Citations of included studies will be checked to identify additional studies not identified in the electronic searches. It will include any observational study that considered lipodystrophy as the primary or secondary outcome and that had enrolled adolescent and adult patients with HIV infection who were on current or previous ART for at least 6 months. Data extraction and analysis will be performed independently by two reviewers. The extracted data will be discussed, decisions documented and, where necessary, the authors of the studies will be contacted for clarification. Measures of frequency, prevalence and incidence of lipodystrophy will be stratified according to definition, method of diagnosis and risk factors of the outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethics is not required given this is a protocol for a systematic review. The findings of this study will be widely disseminated through peer-reviewed publications and conference presentations. Updates of the review will be conducted to inform and guide healthcare practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Protocol registration<\/jats:title>\n                    <jats:p>PROSPERO\u201442013005450.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2013-004088","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T23:09:17Z","timestamp":1394752157000},"page":"e004088","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Lipodystrophy among patients with HIV infection on antiretroviral therapy: a systematic review protocol"],"prefix":"10.1136","volume":"4","author":[{"given":"Lorena Gomes Cunha","family":"Lana","sequence":"first","affiliation":[{"name":"Departamento de Farm\u00e1cia Social, Faculdade de Farm\u00e1cia, Centro de Estudos do Medicamento (Cemed), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Rezende Garcia","family":"Junqueira","sequence":"additional","affiliation":[{"name":"Departamento de Farm\u00e1cia Social, Faculdade de Farm\u00e1cia, Centro de Estudos do Medicamento (Cemed), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil"},{"name":"Faculty of Health Sciences, The University of Sydney, Sydney, Australia"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade de Sorocaba-Uniso, Sorocaba, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson","family":"Perini","sequence":"additional","affiliation":[{"name":"Departamento de Farm\u00e1cia Social, Faculdade de Farm\u00e1cia, Centro de Estudos do Medicamento (Cemed), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane","family":"Menezes de P\u00e1dua","sequence":"additional","affiliation":[{"name":"Departamento de Farm\u00e1cia Social, Faculdade de Farm\u00e1cia, Centro de Estudos do Medicamento (Cemed), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,3,13]]},"reference":[{"key":"2025121510474973000_4.3.e004088.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(01)00070-1"},{"key":"2025121510474973000_4.3.e004088.2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000191484.84661.2b"},{"key":"2025121510474973000_4.3.e004088.3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1590\/S1807-59322009000900007","article-title":"Quality of life among HIV\/aids patients after initiating antiretroviral 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Metabol"},{"key":"2025121510474973000_4.3.e004088.11","doi-asserted-by":"crossref","first-page":"63623","DOI":"10.1371\/journal.pone.0063623","article-title":"Systematic review of antiretroviral-associated lipodystrophy: lipoatrophy, but not central fat gain, is an antiretroviral adverse drug reaction","volume":"8","author":"de Waal","year":"2013","journal-title":"PLoS ONE"},{"key":"2025121510474973000_4.3.e004088.12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020794"},{"key":"2025121510474973000_4.3.e004088.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12656-6"},{"key":"2025121510474973000_4.3.e004088.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041811"},{"key":"2025121510474973000_4.3.e004088.15","unstructured":"University of York. 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