{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:38:15Z","timestamp":1772163495749,"version":"3.50.1"},"reference-count":17,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2013,12,10]]},"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare collagenase injections and surgery (fasciectomy) for Dupuytren's contracture (DC) regarding actual total direct treatment costs and short-term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Orthopaedic department of a regional hospital in Sweden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients aged 65\u2005years or older with previously untreated DC of 30\u00b0 or greater in the metacarpophalangeal (MCP) and\/or proximal interphalangeal (PIP) joints of the small, ring or middle finger. The collagenase group comprised 16 consecutive patients treated during the first 6\u2005months following the introduction of collagenase as treatment for DC at the study centre. The controls were 16 patients randomly selected among those operated on with fasciectomy at the same centre during the preceding 3\u2005years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Treatment with collagenase was given during two standard outpatient clinic visits (injection of 0.9\u2005mg, distributed at multiple sites in a palpable cord, and next-day finger extension under local anaesthesia) followed by night-time splinting. Fasciectomy was carried out in the operating room (day surgery) under general or regional anaesthesia using standard technique, followed by therapy and splinting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Actual total direct costs (salaries of all medical personnel involved in care, medications, materials and other relevant costs), and total MCP and PIP extension deficit (degrees) measured by hand therapists at 6\u201312\u2005weeks after the treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Collagenase injection required fewer hospital outpatient visits to a therapist and nurse than fasciectomy. Total treatment cost for collagenase injection was US$1418.04 and for fasciectomy US$2102.56. The post-treatment median (IQR) total extension deficit was 10 (0\u201330) for the collagenase group and 10 (0\u201334) for the fasciectomy group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment of DC with one collagenase injection costs 33% less than fasciectomy with equivalent efficacy at 6\u2005weeks regarding reduction in contracture.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2013-004166","type":"journal-article","created":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T20:49:20Z","timestamp":1389905360000},"page":"e004166","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":51,"title":["Costs for collagenase injections compared with fasciectomy in the treatment of Dupuytren's contracture: a retrospective cohort study"],"prefix":"10.1136","volume":"4","author":[{"given":"Isam","family":"Atroshi","sequence":"first","affiliation":[{"name":"Department of Orthopedics H\u00e4ssleholm-Kristianstad-Ystad, H\u00e4ssleholm Hospital, H\u00e4ssleholm, Sweden"},{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emelie","family":"Strandberg","sequence":"additional","affiliation":[{"name":"Department of Orthopedics H\u00e4ssleholm-Kristianstad-Ystad, H\u00e4ssleholm Hospital, H\u00e4ssleholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Lauritzson","sequence":"additional","affiliation":[{"name":"Department of Orthopedics H\u00e4ssleholm-Kristianstad-Ystad, H\u00e4ssleholm Hospital, H\u00e4ssleholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Ahlgren","sequence":"additional","affiliation":[{"name":"Department of Orthopedics H\u00e4ssleholm-Kristianstad-Ystad, H\u00e4ssleholm Hospital, H\u00e4ssleholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Wald\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Orthopedics H\u00e4ssleholm-Kristianstad-Ystad, H\u00e4ssleholm Hospital, H\u00e4ssleholm, Sweden"},{"name":"Department of Medical and Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"2025121221464231000_4.1.e004166.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2011.03.002"},{"key":"2025121221464231000_4.1.e004166.2","unstructured":"Statistical Databse. The National Board of Health and Welfare . 2013. http:\/\/www.socialstyrelsen.se\/statistik\/statistikdatabas\/dagkirurgi (accessed 14 Sep 2013)."},{"key":"2025121221464231000_4.1.e004166.3","unstructured":"Sk\u00e5ne County. Annual Report. Sk\u00e5ne County. 2010. http:\/\/www.skane.se\/upload\/Webbplatser\/Skaneportalen-extern\/OmRegionSkane\/ekonomi\/arsredovisning\/2010\/\u00c5R_2010_110426.pdf (accessed 14 Sep 2013)."},{"key":"2025121221464231000_4.1.e004166.4","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12106"},{"key":"2025121221464231000_4.1.e004166.5","doi-asserted-by":"publisher","DOI":"10.1177\/1753193410397971"},{"key":"2025121221464231000_4.1.e004166.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-008-0657-z"},{"key":"2025121221464231000_4.1.e004166.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810866"},{"key":"2025121221464231000_4.1.e004166.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2011.08.004"},{"key":"2025121221464231000_4.1.e004166.9","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/SAP.0b013e31827e531d","article-title":"Cost comparison of open fasciectomy versus percutaneous needle aponeurotomy for treatment of Dupuytren contracture","volume":"70","author":"Herrera","year":"2013","journal-title":"Ann Plast Surg"},{"key":"2025121221464231000_4.1.e004166.10","unstructured":"Hurst L . Dupuytren's contracture. In: Wolfe SW Hotchkiss RN Pederson WC Kozin SH , eds. Green's operative hand surgery. 6th edn. Philadelphia, PA: Elsevier, 2010:153\u20134."},{"key":"2025121221464231000_4.1.e004166.11","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31823aea95"},{"key":"2025121221464231000_4.1.e004166.12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-13-61"},{"key":"2025121221464231000_4.1.e004166.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2013.01.038"},{"key":"2025121221464231000_4.1.e004166.14","doi-asserted-by":"crossref","unstructured":"Manning CJ Delaney R Hayton MJ . Efficacy and tolerability of day 2 manipulation and local anaesthesia after collagenase injection in patients with Dupuytren's contracture. J Hand Surg Eur 2013. 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