{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:34:45Z","timestamp":1792373685696,"version":"4.4.0"},"reference-count":23,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2013,12,20]]},"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In view of the debate of factors in Dupuytren\u2019s disease, we aimed to describe its relationship with certain occupational factors, alcohol intake and smoking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The French GAZEL cohort (employees of Electricit\u00e9 de France and Gaz de France).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Participants of the cohort who answered a questionnaire in 2012, that is, 13\u2005587 participants (73.7% of the questionnaire sent). In 2007, self-assessed lifetime occupational biomechanical exposure was recorded (carrying loads, manipulating a vibrating tool and climbing stairs), as well as alcohol intake, smoking and diabetes mellitus. Analyses were performed on high alcohol intake, smoking and duration of relevant work exposure, stratified by gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>From a specific question on Dupuytren\u2019s disease assessed in 2012, the outcome measures were self-reported Dupuytren\u2019s disease (yes\/no) and disabling Dupuytren\u2019s disease (including surgery).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 10\u2005017 men and 3570 women, aged 64\u201373\u2005years, were included; the mean age for men was 68\u2005years and for women was 65\u2005years. Among men, the following were significantly associated with Dupuytren\u2019s disease: age (OR 1.03 (1.00; 1.06)), diabetes (OR 1.31 (1.07; 1.60)), heavy drinking (OR 1.36 (1.10; 1.69)) and over 15\u2005years of manipulating a vibrating tool at work (OR 1.52 (1.15; 2.02)); except for diabetes, the association with these factors was stronger for disabling Dupuytren\u2019s disease (or surgery), with OR 1.07 (1.03; 1.11), 1.71 (1.25; 2.33) and 1.98(1.34; 2.91), respectively, for age, heavy drinking and over 15\u2005years of manipulating a vibrating tool at work. Among the 3570 women included, 160 reported Dupuytren\u2019s disease (4.5%). The number of cases in the group of women was too low to reach conclusions, although the findings seemed similar for age, diabetes and vibration exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large French cohort study, Dupuytren\u2019s disease in men was associated with high levels of alcohol consumption and exposure to hand-transmitted vibration. It is likely that the same applied to women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2013-004214","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T21:38:24Z","timestamp":1391031504000},"page":"e004214","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":51,"title":["Association among work exposure, alcohol intake, smoking and Dupuytren's disease in a large cohort study (GAZEL)"],"prefix":"10.1136","volume":"4","author":[{"given":"Alexis","family":"Descatha","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Versailles St-Quentin, Versailles, France"},{"name":"Centre for Research in Epidemiology and Population Health (CESP), U1018, \u201cPopulation-Based Epidemiological Cohorts\u201d Research Platform, INSERM, Villejuif, France"},{"name":"AP-HP, Occupational Health Unit\/EMS (Samu92), University Hospital of Paris West Suburb, Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Carton","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Versailles St-Quentin, Versailles, France"},{"name":"Centre for Research in Epidemiology and Population Health (CESP), U1018, \u201cPopulation-Based Epidemiological Cohorts\u201d Research Platform, INSERM, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakia","family":"Mediouni","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Versailles St-Quentin, Versailles, France"},{"name":"Centre for Research in Epidemiology and Population Health (CESP), U1018, \u201cPopulation-Based Epidemiological Cohorts\u201d Research Platform, INSERM, Villejuif, France"},{"name":"AP-HP, Occupational Health Unit\/EMS (Samu92), University Hospital of Paris West Suburb, Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dumontier","sequence":"additional","affiliation":[{"name":"Plastic and Hand Department, Nice University, St Roch Hospital, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Roquelaure","sequence":"additional","affiliation":[{"name":"Laboratory of Ergonomics and Epidemiology in Occupational Health, LUNAM University, University of Angers, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Versailles St-Quentin, Versailles, France"},{"name":"Centre for Research in Epidemiology and Population Health (CESP), U1018, \u201cPopulation-Based Epidemiological Cohorts\u201d Research Platform, INSERM, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Zins","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Versailles St-Quentin, Versailles, France"},{"name":"Centre for Research in Epidemiology and Population Health (CESP), U1018, \u201cPopulation-Based Epidemiological Cohorts\u201d Research Platform, INSERM, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Leclerc","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Versailles St-Quentin, Versailles, France"},{"name":"Centre for Research in Epidemiology and Population Health (CESP), U1018, \u201cPopulation-Based Epidemiological Cohorts\u201d Research Platform, INSERM, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"2025121601313761000_4.1.e004214.1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7538.397"},{"key":"2025121601313761000_4.1.e004214.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13871-8"},{"key":"2025121601313761000_4.1.e004214.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1101029"},{"key":"2025121601313761000_4.1.e004214.4","doi-asserted-by":"crossref","unstructured":"Eaton C, Seegenschmiedt MH, Bayat A, et al., ed. 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