{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T22:40:43Z","timestamp":1789339243041,"version":"build-2803163510"},"reference-count":21,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2014,2,26]]},"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Vasodilation of the peripheral arteries during reactive hyperaemia depends in part on release of nitric oxide from endothelial cells. Previous studies mainly employed a fingertip tonometric device to derive pulse wave amplitude (PWA) and PWA hyperaemic changes. An alternative approach is based on photoplethysmography (PPG). We sought to evaluate the correlates of digital PPG PWA hyperaemic responses as a measure of peripheral vascular function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>The Flemish Study on Environment, Genes and Health Outcomes (FLEMENGHO) is a population-based cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Respondents were examined at one centre in northern Belgium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>For this analysis, our sample consisted of 311 former participants (53.5% women; mean age 52.6\u2005years; 43.1% hypertensive), who were examined from January 2010 until March 2012 (response rate 85.1%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary outcome measures<\/jats:title>\n                    <jats:p>Using a fingertip PPG device, we measured digital PWA at baseline and at 30\u2005s intervals for 4\u2005min during reactive hyperaemia induced by a 5\u2005min forearm cuff occlusion. We performed stepwise regression to identify correlates of the hyperaemic response ratio for each 30\u2005s interval after cuff deflation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The maximal hyperaemic response was detected in the 30\u201360\u2005s interval. The explained variance for the PPG PWA ratio ranged from 9.7% at 0\u201330\u2005s interval to 22.5% at 60\u201390\u2005s time interval. The hyperaemic response at each 30\u2005s interval was significantly higher in women compared with men (p\u22640.001). The PPG PWA changes at 0\u201390\u2005s intervals decreased with current smoking (p\u22640.0007) and at 0\u2013240\u2005s intervals decreased with higher body mass index (p\u22640.035). These associations with sex, current smoking and body mass index were mutually independent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study is the first to implement the new PPG technique to measure digital PWA hyperaemic changes in a general population. Hyperaemic response, as measured by PPG, is inversely associated with traditional cardiovascular risk factors such as male sex, smoking and obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2013-004399","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T01:13:23Z","timestamp":1395710003000},"page":"e004399","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Association of digital vascular function with cardiovascular risk factors: a population study"],"prefix":"10.1136","volume":"4","author":[{"given":"Tatiana","family":"Kuznetsova","sequence":"first","affiliation":[{"name":"Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"Van Vlierberghe","sequence":"additional","affiliation":[{"name":"Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judita","family":"Knez","sequence":"additional","affiliation":[{"name":"Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Szczesny","sequence":"additional","affiliation":[{"name":"FLOMEDI Company, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutgarde","family":"Thijs","sequence":"additional","affiliation":[{"name":"Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, 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