{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:35:55Z","timestamp":1792730155805,"version":"4.5.0"},"reference-count":31,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2014,11,17]]},"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Unilateral haemodynamically significant large-vessel intracranial stenosis may be associated with reduced blood-oxygen-level-dependent (BOLD) cerebrovascular reactivity (CVR), an indicator of autoregulatory reserve. Reduced CVR has been associated with ipsilateral cortical thinning and loss in cognitive function. These effects have been shown to be reversible following revascularisation. Our aim was to study the effects of unilateral revascularisation on CVR in the non-intervened hemisphere in bilateral steno-occlusive or Moyamoya disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>A retrospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A routine follow-up assessment of CVR after a revascularisation procedure at a research teaching hospital in Toronto (Journal wants us to generalise).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Thirteen patients with bilateral Moyamoya disease (age range 18 to 52\u2005years; 3 males), seven patients with steno-occlusive disease (age range 18 to 78\u2005years; six males) and 27 approximately age-matched normal control subjects (age range 19\u201371\u2005years; 16 males) with no history or findings suggestive of any neurological or systemic disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>\n                      Participants underwent BOLD CVR MRI using computerised prospective targeting of CO\n                      <jats:sub>2<\/jats:sub>\n                      , before and after unilateral revascularisation (extracranial\u2013intracranial bypass, carotid endarterectomy or encephaloduroarteriosynangiosis). Pre-revascularisation and post-revascularisation CVR was assessed in each major arterial vascular territory of both hemispheres.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>As expected, surgical revascularisation improved grey matter CVR in the middle cerebral artery (MCA) territory of the intervened hemisphere (0.010\u00b10.023 to 0.143\u00b10.010%BOLD\/mm\u2005Hg, p&lt;0.01). There was also a significant post-revascularisation improvement in grey matter CVR in the MCA territory of the non-intervened hemisphere (0.101\u00b10.025 to 0.165\u00b10.015%BOLD\/mm\u2005Hg, p&lt;0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Not only does CVR improve in the hemisphere ipsilateral to a flow restoration procedure, but it also improves in the non-intervened hemisphere. This highlights the potential of CVR mapping for staging and evaluating surgical interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2014-006014","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:19:16Z","timestamp":1423700356000},"page":"e006014","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["Assessing the effect of unilateral cerebral revascularisation on the vascular reactivity of the non-intervened hemisphere: a retrospective observational study"],"prefix":"10.1136","volume":"5","author":[{"given":"Kevin","family":"Sam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Poublanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Sobczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay S","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Battisti-Charbonney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M","family":"Mandell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tymianski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian P","family":"Crawley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Mikulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,2,11]]},"reference":[{"key":"2024051512443845000_5.2.e006014.1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.579540"},{"key":"2024051512443845000_5.2.e006014.2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.188078"},{"key":"2024051512443845000_5.2.e006014.3","first-page":"161","article-title":"Cerebral autoregulation","volume":"2","author":"Paulson","year":"1990","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"2024051512443845000_5.2.e006014.4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3109\/02688697.2012.757294","article-title":"Cerebral hyperperfusion syndrome after revascularization surgery in patients with Moyamoya disease","volume":"27","author":"Zhao","year":"2013","journal-title":"Br J Neurosurg"},{"key":"2024051512443845000_5.2.e006014.5","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.501692"},{"key":"2024051512443845000_5.2.e006014.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.16.2122"},{"key":"2024051512443845000_5.2.e006014.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.03.018"},{"key":"2024051512443845000_5.2.e006014.8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318270402e"},{"key":"2024051512443845000_5.2.e006014.9","doi-asserted-by":"publisher","DOI":"10.1007\/BF03007690"},{"key":"2024051512443845000_5.2.e006014.10","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.608521"},{"key":"2024051512443845000_5.2.e006014.11","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.224"},{"key":"2024051512443845000_5.2.e006014.12","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000086465.41263.06"},{"key":"2024051512443845000_5.2.e006014.13","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70195-8"},{"key":"2024051512443845000_5.2.e006014.14","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.193"},{"key":"2024051512443845000_5.2.e006014.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2005.08.012"},{"key":"2024051512443845000_5.2.e006014.16","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.12.2188"},{"key":"2024051512443845000_5.2.e006014.17","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.129395"},{"key":"2024051512443845000_5.2.e006014.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2007.07.007"},{"key":"2024051512443845000_5.2.e006014.19","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1134"},{"key":"2024051512443845000_5.2.e006014.20","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.259150"},{"key":"2024051512443845000_5.2.e006014.21","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"2024051512443845000_5.2.e006014.22","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2365"},{"key":"2024051512443845000_5.2.e006014.23","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10143-011-0312-y","article-title":"Contralateral cerebral hemodynamic changes after unilateral direct revascularization in patients with Moyamoya disease","volume":"34","author":"Ma","year":"2011","journal-title":"Neurosurg Rev"},{"key":"2024051512443845000_5.2.e006014.24","doi-asserted-by":"publisher","DOI":"10.1161\/hs0901.095692"},{"key":"2024051512443845000_5.2.e006014.25","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.154716"},{"key":"2024051512443845000_5.2.e006014.26","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000167"},{"key":"2024051512443845000_5.2.e006014.27","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000250973.93401.2d"},{"key":"2024051512443845000_5.2.e006014.28","first-page":"699","article-title":"The improvement of cognition and personality after carotid endarterectomy","volume":"80","author":"Haynes","year":"1976","journal-title":"Surgery"},{"key":"2024051512443845000_5.2.e006014.29","doi-asserted-by":"publisher","DOI":"10.1159\/000228254"},{"key":"2024051512443845000_5.2.e006014.30","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000019511.81583.A8"},{"key":"2024051512443845000_5.2.e006014.31","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1161\/01.STR.32.7.1552","article-title":"Effect of collateral blood flow and cerebral vasomotor reactivity on the outcome of carotid artery occlusion","volume":"32","author":"Vernieri","year":"2001","journal-title":"Stroke"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2014-006014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T16:01:30Z","timestamp":1715788890000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2014-006014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,11]]},"published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1136\/bmjopen-2014-006014"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2014-006014","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}