{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:42:21Z","timestamp":1783096941671,"version":"3.54.6"},"reference-count":30,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,3,18]]},"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Complete prevention of diabetic neuropathies has not been previously demonstrated. We sought to determine whether long-term near-normoglycaemia maintained from the diagnosis of type 1 diabetes is associated with polyneuropathy and cardiac autonomic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective observational study over 24\u2005years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Ambulatory care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>32 newly diagnosed patients with type 1 diabetes aged 20.3\u00b11.0\u2005years, duration of diabetes 2.7\u00b10.3\u2005weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Insulin therapy according to standards of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Motor and sensory nerve conduction velocity (MNCV and SNCV), heart rate variability (HRV), and confirmed clinical polyneuropathy measured at 15 time points over 24\u2005years and quantitative sensory testing (QST) determined over 20\u201322\u2005years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>11 patients were well controlled over 24\u2005years with mean glycated haemoglobin (HbA1c) &lt;7.0% (6.5\u00b10.1%; group 1), whereas 21 patients were poorly controlled (mean HbA1c \u22657.0%: 8.3\u00b10.2%; group 2). After 24\u2005years, MNCV was faster in group 1 versus group 2 in the median (55.5\u00b11.6 vs 48.9\u00b11.6\u2005m\/s), ulnar (56.5\u00b11.5 vs 49.3\u00b11.7\u2005m\/s) and peroneal nerve (44.7\u00b11.6 vs 36.8\u00b12.5\u2005m\/s), while SNCV was faster in the median (53.6\u00b11.6 vs 45.5\u00b12.8\u2005m\/s), ulnar (54.7\u00b11.8 vs 43.0\u00b13.9\u2005m\/s), and sural nerve (44.5\u00b11.8 vs 35.5\u00b12.6\u2005m\/s; all p&lt;0.05). The annual decline in peroneal MNCV and sural SNCV in group 1 was sixfold and threefold faster in group 2 than in group 1, respectively. Likewise, impairment in QST and HRV developed at faster rates in group 2. After 24\u2005years, 64% of patients in group 2, but none in group 1, developed confirmed clinical polyneuropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Near-normoglycaemia maintained from the diagnosis of type 1 diabetes over 24\u2005years was associated with a complete prevention of the decline in hyperglycaemia-related peripheral and autonomic nerve function, and development of confirmed clinical polyneuropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2014-006559","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T21:26:00Z","timestamp":1435181160000},"page":"e006559","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Near-normoglycaemia and development of neuropathy: a 24-year prospective study from diagnosis of type 1 diabetes"],"prefix":"10.1136","volume":"5","author":[{"given":"Dan","family":"Ziegler","sequence":"first","affiliation":[{"name":"Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, D\u00fcsseldorf, Germany"},{"name":"Department of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarete","family":"Behler","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Schroers-Teuber","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Roden","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, D\u00fcsseldorf, Germany"},{"name":"Department of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,6,24]]},"reference":[{"key":"2025121513094102000_5.6.e006559.1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.4.956"},{"key":"2025121513094102000_5.6.e006559.2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.634949"},{"key":"2025121513094102000_5.6.e006559.3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440370091009"},{"key":"2025121513094102000_5.6.e006559.4","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0525"},{"key":"2025121513094102000_5.6.e006559.5","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2114"},{"key":"2025121513094102000_5.6.e006559.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.16.2159"},{"key":"2025121513094102000_5.6.e006559.7","doi-asserted-by":"crossref","unstructured":"Pop-Busui R , Herman WH , Feldman EL , et al . 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