{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:12:51Z","timestamp":1778073171300,"version":"3.51.4"},"reference-count":30,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2014,10,30]]},"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effectiveness of tonsillectomy in reducing acute throat infection (ATI) consultation rates over 6\u2005years\u2019 follow-up among children with low baseline ATI consultation rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>UK general practices from the Clinical Practice Research Datalink.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Children aged 4\u201315\u2005years with \u22643 ATI consultations during the 3\u2005years prior to 2001 (baseline). 450 children who underwent tonsillectomy (tonsillectomy group) and 13\u2005442 other children with an ATI consultation (comparison group) in 2001.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Mean differences in ATI consultation rates over the first 3\u2005years\u2019 and subsequent 3\u2005years\u2019 follow-up compared with 3\u2005years prior to 2001 (baseline); odds of \u22653 ATI consultations at the same time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among children in the tonsillectomy group, the 3-year mean ATI consultation rate decreased from 1.31 to 0.66 over the first 3\u2005years\u2019 follow-up and further declined to 0.60 over the subsequent 3\u2005years\u2019 follow-up period. Compared with children who had no operation, those who underwent tonsillectomy experienced a reduction in 3-year mean ATI consultations per child of 2.5 (95% CI 2.3 to 2.6, p&lt;0.001) over the first 3\u2005years\u2019 follow-up, but only 1.2 (95% CI 1.0 to 1.4, p&lt;0.001) over the subsequent 3\u2005years\u2019 follow-up compared with baseline, respectively. This equates to a mean reduction of 3.7 ATI consultations over a 6-year period and approximates to a mean annual reduction of 0.6 ATI consultations per child, per year, over 6\u2005years\u2019 follow-up. Children who underwent tonsillectomy were also much less likely to experience \u22653 ATI consultations during the first 3\u2005years\u2019 follow-up (adjusted OR=0.12, 95% CI 0.08 to 0.17) and the subsequent 3\u2005years\u2019 follow-up (adjusted OR=0.24, 95% CI 0.14 to 0.41).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among children with low baseline ATI rates, there was a statistically significant reduction in ATI consultation rates over 6\u2005years\u2019 follow-up. However, the relatively modest clinical benefit needs to be weighed against the potential risks and complications associated with surgery.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2014-006686","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T04:02:59Z","timestamp":1423022579000},"page":"e006686","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Tonsillectomy among children with low baseline acute throat infection consultation rates in UK general practices: a cohort study"],"prefix":"10.1136","volume":"5","author":[{"given":"Elizabeth","family":"Koshy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Watt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasa","family":"Curcin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Bottle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Sharland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,2,3]]},"reference":[{"key":"2024051513070636000_5.2.e006686.1","unstructured":"SIGN. 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