{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:03:11Z","timestamp":1785855791264,"version":"3.56.0"},"reference-count":31,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,1,12]]},"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hyperglycaemia is very common during exacerbations of asthma and chronic obstructive pulmonary disease (COPD). However, its clinical significance is not clear. The objective of the present study was to assess whether exacerbation-associated hyperglycaemia affects long-term mortality in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A prospective, observational cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A single hospital in eastern Finland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>153 consecutive patients who were hospitalised due to mild to moderate obstructive lung disease exacerbation (110 with asthma and 43 with COPD) and who survived at least 30\u2005days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Plasma glucose levels were recorded seven times during the first day on the ward. Several possible confounders were also recorded. The median follow-up time was 6\u2005years and 2\u2005months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the follow-up, 57 (37%) of the patients died. Previously diagnosed diabetes was strongly associated with elevated mortality (adjusted HR (aHR) 3.03 (1.28 to 7.18). The highest fasting glucose value (aHR 1.10 (1.01 to 1.20) per 1\u2005mmol\/L) and the highest postprandial glucose value ((aHR 1.07 (1.00 to 1.16)) were also associated with late mortality. However, the associations between highest glucose values and mortality vanished when the diagnosis of diabetes was included in the same model. Within the patients without diabetes, neither fasting (aHR 0.92 (0.42 to 2.02)) nor postprandial ((aHR 1.04 (0.50 to 2.12)) hyperglycaemia was associated with late mortality. There were no statistically significant differences in the underlying causes of death between the patients with and without diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A history of diabetes but not hyperglycaemia during exacerbation of obstructive lung disease has impact on long-term mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2014-006794","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T23:30:33Z","timestamp":1422574233000},"page":"e006794","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["A history of diabetes but not hyperglycaemia during exacerbation of obstructive lung disease has impact on long-term mortality: a prospective, observational cohort study"],"prefix":"10.1136","volume":"5","author":[{"given":"Heikki O","family":"Koskela","sequence":"first","affiliation":[{"name":"Pulmonary Division, Unit for Medicine and Clinical Research, Kuopio University Hospital, Kuopio, Finland"},{"name":"Faculty of Health Sciences, School of Medicine, Institute of Clinical Sciences, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi H","family":"Salonen","sequence":"additional","affiliation":[{"name":"Pulmonary Division, Unit for Medicine and Clinical Research, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarkko","family":"Romppanen","sequence":"additional","affiliation":[{"name":"Eastern Finland Laboratory Centre, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Niskanen","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, School of Medicine, Institute of Clinical Sciences, University of Eastern Finland, Kuopio, Finland"},{"name":"Finnish Medicines Agency Fimea, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,1,29]]},"reference":[{"key":"2025121603114327000_5.1.e006794.1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/crj.12020","article-title":"Hyperglycaemia during exacerbations of asthma and chronic obstructive pulmonary disease","volume":"7","author":"Koskela","year":"2013","journal-title":"Clin Respir J"},{"key":"2025121603114327000_5.1.e006794.2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200110000-00006"},{"key":"2025121603114327000_5.1.e006794.3","first-page":"71","article-title":"Mechanisms of abnormal glucose metabolism during the treatment of acute severe asthma","volume":"82","author":"Smith","year":"1992","journal-title":"Q J Med"},{"key":"2025121603114327000_5.1.e006794.4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1651-2227.1995.tb13633.x","article-title":"Acute asthma, salbutamol and hyperglycaemia","volume":"84","author":"Dawson","year":"1995","journal-title":"Acta Paediatr"},{"key":"2025121603114327000_5.1.e006794.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60553-5"},{"key":"2025121603114327000_5.1.e006794.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(02)00297-8"},{"key":"2025121603114327000_5.1.e006794.7","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.051029"},{"key":"2025121603114327000_5.1.e006794.8","first-page":"571","article-title":"Long-term survival in patients hospitalized for chronic obstructive pulmonary disease: a prospective observational study in the Nordic countries","volume":"7","author":"Gudmundsson","year":"2012","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2025121603114327000_5.1.e006794.9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1513\/AnnalsATS.201208-043OC","article-title":"Predictors of mortality in hospitalized adults with acute exacerbation of chronic obstructive pulmonary disease","volume":"10","author":"Singanayagam","year":"2013","journal-title":"Ann Am Thorac Soc"},{"key":"2025121603114327000_5.1.e006794.10","unstructured":"Hitchings AW , Archer JR , Srivastava SA , et al . 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