{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T04:20:49Z","timestamp":1776572449404,"version":"3.51.2"},"reference-count":43,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,3,1]]},"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The purpose of this study is to report the prevalence, clinical characteristics, precipitating factors, management and outcome of patients with prior stroke hospitalised with acute heart failure (HF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective analysis of prospectively collected data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Data were derived from Gulf CARE (Gulf aCute heArt failuRe rEgistry), a prospective multicentre study of consecutive patients hospitalised with acute HF in 2012 in seven Middle Eastern countries and analysed according to the presence or absence of prior stroke; demographics, management and outcomes were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A total of 5005 patients with HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>In-hospital and 1-year outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of prior stroke in patients with HF was 8.1%. Patients with stroke with HF were more likely to be admitted under the care of internists rather than cardiologists. When compared with patients without stroke, patients with stroke were more likely to be older and to have diabetes mellitus, hypertension, atrial fibrillation, hyperlipidaemia, chronic kidney disease, ischaemic heart disease, peripheral arterial disease and left ventricular dysfunction (p=0.001 for all). Patients with stroke were less likely to be smokers (0.003). There were no significant differences in terms of precipitating risk factors for HF hospitalisation between the two groups. Patients with stroke with HF had a longer hospital stay (mean\u00b1SD days; 11\u00b114 vs 9\u00b113, p=0.03), higher risk of recurrent strokes and 1-year mortality rates (32.7% vs 23.2%, p=0.001). Multivariate logistic regression analysis showed that stroke is an independent predictor of in-hospital and 1-year mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This observational study reports high prevalence of prior stroke in patients hospitalised with HF. Internists rather than cardiologists were the predominant caregivers in this high-risk group. Patients with stroke had higher risk of in-hospital recurrent strokes and long-term mortality rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>NCT01467973.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2014-007148","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T22:52:03Z","timestamp":1429829523000},"page":"e007148","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical characteristics, precipitating factors, management and outcome of patients with prior stroke hospitalised with heart failure: an observational report from the Middle East"],"prefix":"10.1136","volume":"5","clinical-trial-number":[{"clinical-trial-number":"nct01467973","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Hadi A R","family":"Khafaji","sequence":"first","affiliation":[{"name":"Department of Cardiology, Saint Michael's Hospital, Toronto University, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadhim","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Hospital, Muscat, Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajvir","family":"Singh","sequence":"additional","affiliation":[{"name":"Biostatistics Section, Cardiovascular Research, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid F","family":"AlHabib","sequence":"additional","affiliation":[{"name":"Department of Cardiac Sciences, King Fahad Cardiac Center, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidal","family":"Asaad","sequence":"additional","affiliation":[{"name":"Adult Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alawi","family":"Alsheikh-Ali","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sheikh Khalifa Medical City, Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Al-Jarallah","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sabah Al-Ahmed Cardiac Center, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassam","family":"Bulbanat","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sabah Al-Ahmed Cardiac Center, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael","family":"AlMahmeed","sequence":"additional","affiliation":[{"name":"Adult Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Ridha","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Adan Hospital, Kuwait, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nooshin","family":"Bazargani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dubai hospital, Dubai, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitham","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mohammed Bin Khalifa Cardiac Center, Manamah, Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Al-Motarreb","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Sana'a University, Sana'a, Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussam","family":"AlFaleh","sequence":"additional","affiliation":[{"name":"Department of Cardiac Sciences, King Fahad Cardiac Center, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelfatah","family":"Elasfar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Prince Salman Heart Center, King Fahad Medical City, Saudi Arabia"},{"name":"Department or Cardiology, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashanth","family":"Panduranga","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Hospital, Muscat, Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jassim","family":"Al Suwaidi","sequence":"additional","affiliation":[{"name":"Biostatistics Section, Cardiovascular Research, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"},{"name":"Qatar Cardiovascular Research Center and Adult Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"2025120518571359000_5.4.e007148.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00115-010-3093-6"},{"key":"2025120518571359000_5.4.e007148.2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.2.288"},{"key":"2025120518571359000_5.4.e007148.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.8.983"},{"key":"2025120518571359000_5.4.e007148.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.12.004"},{"key":"2025120518571359000_5.4.e007148.5","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.50.591"},{"key":"2025120518571359000_5.4.e007148.6","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1742"},{"key":"2025120518571359000_5.4.e007148.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00033-9"},{"key":"2025120518571359000_5.4.e007148.8","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.561670"},{"key":"2025120518571359000_5.4.e007148.9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.661397"},{"key":"2025120518571359000_5.4.e007148.10","doi-asserted-by":"publisher","DOI":"10.1053\/jscd.2001.26870"},{"key":"2025120518571359000_5.4.e007148.11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1983.03340210040022"},{"key":"2025120518571359000_5.4.e007148.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.10.018"},{"key":"2025120518571359000_5.4.e007148.13","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000047852.05842.3C"},{"key":"2025120518571359000_5.4.e007148.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2008.09.001"},{"key":"2025120518571359000_5.4.e007148.15","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000227121.34717.40"},{"key":"2025120518571359000_5.4.e007148.16","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0677-1"},{"key":"2025120518571359000_5.4.e007148.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.09.002"},{"key":"2025120518571359000_5.4.e007148.18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4103\/1995-705X.132137","article-title":"Rationale, Design, Methodology and Hospital Characteristics of the First Gulf Acute Heart Failure Registry (Gulf CARE)","volume":"15","author":"Sulaiman","year":"2014","journal-title":"Heart Views"},{"key":"2025120518571359000_5.4.e007148.19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.170073"},{"key":"2025120518571359000_5.4.e007148.20","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn309"},{"key":"2025120518571359000_5.4.e007148.21","doi-asserted-by":"crossref","unstructured":"Hosmer DW Jr , Lemeshow S , Sturdivant RX . Introduction to the Logistic Regression Model, in Applied Logistic Regression. 3rd edn. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. doi:10.1002\/9781118548387.ch1","DOI":"10.1002\/9781118548387"},{"key":"2025120518571359000_5.4.e007148.22","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.628479"},{"key":"2025120518571359000_5.4.e007148.23","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-12-64"},{"key":"2025120518571359000_5.4.e007148.24","doi-asserted-by":"publisher","DOI":"10.1159\/000330344"},{"key":"2025120518571359000_5.4.e007148.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2007.01.009"},{"key":"2025120518571359000_5.4.e007148.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14284-5"},{"key":"2025120518571359000_5.4.e007148.27","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.4.914"},{"key":"2025120518571359000_5.4.e007148.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14282-1"},{"key":"2025120518571359000_5.4.e007148.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00019-3"},{"key":"2025120518571359000_5.4.e007148.30","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14283-3"},{"key":"2025120518571359000_5.4.e007148.31","doi-asserted-by":"crossref","unstructured":"Remme W , Cleland J , DiLenarda A , et al . Carvedilol better protects against vascular events than metoprolol in heart failure: results from COMET. J Am Coll Cardiol 2004;43(Suppl 1):A205\u20136. doi:10.1016\/S0735-1097(04)90875-3","DOI":"10.1016\/S0735-1097(04)90875-3"},{"key":"2025120518571359000_5.4.e007148.32","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9520-y"},{"key":"2025120518571359000_5.4.e007148.33","doi-asserted-by":"crossref","unstructured":"Heuschmann PU , Kircher J , Nowe T , et al . Control of main risk factors after ischaemic stroke across Europe: data from the stroke-specific module of the EUROASPIRE III survey. Eur J Prev Cardiol 2014 . doi:10.1177\/2047487314546825 [Epub ahead of print 19 Aug 2014].","DOI":"10.1177\/2047487314546825"},{"key":"2025120518571359000_5.4.e007148.34","doi-asserted-by":"publisher","DOI":"10.1159\/000149581"},{"key":"2025120518571359000_5.4.e007148.35","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701233360403"},{"key":"2025120518571359000_5.4.e007148.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.02.071"},{"key":"2025120518571359000_5.4.e007148.37","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1987.00370090041008"},{"key":"2025120518571359000_5.4.e007148.38","first-page":"209","article-title":"Heart failure and cognitive impairment: challenges and opportunities","volume":"2","author":"Heckman","year":"2007","journal-title":"Clin Interv Aging"},{"key":"2025120518571359000_5.4.e007148.39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-5299.2007.06612.x"},{"key":"2025120518571359000_5.4.e007148.40","doi-asserted-by":"publisher","DOI":"10.1097\/01.JCN.0000305096.09710.ec"},{"key":"2025120518571359000_5.4.e007148.41","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00264-X"},{"key":"2025120518571359000_5.4.e007148.42","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(00)90093-0"},{"key":"2025120518571359000_5.4.e007148.43","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000080290.39027.48"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2014-007148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T02:57:24Z","timestamp":1764989844000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2014-007148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,23]]},"published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1136\/bmjopen-2014-007148"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2014-007148","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}