{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T16:33:25Z","timestamp":1765816405628,"version":"3.48.0"},"reference-count":42,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,3,20]]},"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine if the introduction of pneumococcal conjugate vaccine (PCV) in Denmark was associated with a decrease in the rate of ventilation tube (VT) insertions performed by office-based practising ear, nose and throat (ENT) specialists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Population-based register study based on prospectively collected data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Central Denmark Region. Data on VT insertions performed by any office-based practising ENT specialist in the region were collected from the National Health Service Registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>All children below the age of 2\u2005years with a first-time VT insertion from 2001 through 2011.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Age-stratified and gender-stratified standardised incidence rates of first-time VT insertion, and incidence rate ratio for PCV period 2008\u20132011 compared with pre-PCV period 2001\u20132007.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The annual incidence rate of first-time VT insertion in small children increased steadily from 64\/1000 person-years in 2001 to 100\/1000 person-years in 2011. The incidence rate ratio was 1.27 (95% CI 1.24 to 1.30) in the PCV period compared with the pre-PCV period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The introduction of PCV into the Danish childhood immunisation programme in 2007 was not associated with a subsequent decrease in the rate of VT insertions among children below the age of 2\u2005years. Instead, the rate continued to rise, as before the introduction of PCV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>Danish Data Protection Agency: 2007-58-0010.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2014-007151","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T21:35:19Z","timestamp":1433540119000},"page":"e007151","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Association of pneumococcal conjugate vaccination with rates of ventilation tube insertion in Denmark: population-based register study"],"prefix":"10.1136","volume":"5","author":[{"given":"Christina","family":"Groth","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reimar W","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese","family":"Ovesen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,6,5]]},"reference":[{"key":"2025121508290100000_5.6.e007151.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70012-8"},{"key":"2025121508290100000_5.6.e007151.2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.1.12"},{"key":"2025121508290100000_5.6.e007151.3","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000136868.91756.80"},{"key":"2025121508290100000_5.6.e007151.4","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.12.38"},{"key":"2025121508290100000_5.6.e007151.5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.5.1451"},{"key":"2025121508290100000_5.6.e007151.6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a1607"},{"key":"2025121508290100000_5.6.e007151.7","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.ijporl.2014.06.034","article-title":"Increasing rate of middle ear ventilation tube insertion in children in Denmark","volume":"78","author":"Djurhuus","year":"2014","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"2025121508290100000_5.6.e007151.8","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31824de9f6"},{"key":"2025121508290100000_5.6.e007151.9","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200003000-00003"},{"key":"2025121508290100000_5.6.e007151.10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0492"},{"key":"2025121508290100000_5.6.e007151.11","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000133049.30299.5d"},{"key":"2025121508290100000_5.6.e007151.12","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/INF.0b013e31827c9bcc","article-title":"Long-term effect of pneumococcal conjugate vaccines on tympanostomy tube placements","volume":"32","author":"Sarasoja","year":"2013","journal-title":"Pediatr Infect Dis J"},{"key":"2025121508290100000_5.6.e007151.13","unstructured":"Palmu A. 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