{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:07:14Z","timestamp":1762542434133},"reference-count":26,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,5,11]]},"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The endothelial lipase gene (<jats:italic>LIPG<\/jats:italic>) is one of the important genes in the metabolism of high-density lipoprotein cholesterol (HDL-C) and may be involved in the pathogenesis of coronary artery disease (CAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>To investigate the relationship between the common single nucleotide polymorphisms (SNPs) 584C\/T (rs2000813) and \u2212384A\/C (rs3813082) in the<jats:italic>LIPG<\/jats:italic>gene and CAD, allele and genotype frequencies of the two SNPs were analysed in 287 Chinese patients with CAD and 367 controls by the high-resolution melting curve (HRM) method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For 584C\/T, no significant difference in polymorphic distribution was observed between patients and controls. However, the frequencies of allele C (20.2% vs 15%, p=0.013, OR=1.437, 95% CI 1.078 to 1.915) at \u2212384A\/C were significantly increased in patients compared with controls. Haplotype analysis also showed that haplotype CT (12.37% vs 8.72%, p=0.035, OR=1.478, 95% CI 1.034 to 2.112) was significantly higher in patients compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggested that the SNP \u2212384A\/C in the LIPG gene may be associated with risk for CAD and the<jats:italic>LIPG<\/jats:italic>gene may play a role in CAD in the Han Chinese.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2015-007621","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T00:44:46Z","timestamp":1435625086000},"page":"e007621","update-policy":"http:\/\/dx.doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Association of endothelial lipase gene\u2212384A\/C with coronary artery disease in Han Chinese people"],"prefix":"10.1136","volume":"5","author":[{"given":"Liang","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,6,29]]},"reference":[{"key":"2024051513442533000_5.6.e007621.1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09270"},{"key":"2024051513442533000_5.6.e007621.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198911093211907"},{"key":"2024051513442533000_5.6.e007621.3","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e3283515b4b"},{"key":"2024051513442533000_5.6.e007621.4","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0934"},{"key":"2024051513442533000_5.6.e007621.5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.20.14170"},{"key":"2024051513442533000_5.6.e007621.6","doi-asserted-by":"publisher","DOI":"10.1038\/7766"},{"key":"2024051513442533000_5.6.e007621.7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000092889.24713.DC"},{"key":"2024051513442533000_5.6.e007621.8","first-page":"1042","article-title":"Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans","volume":"119","author":"Edmondson","year":"2009","journal-title":"J Clin Invest"},{"key":"2024051513442533000_5.6.e007621.9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.219188"},{"key":"2024051513442533000_5.6.e007621.10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030022"},{"key":"2024051513442533000_5.6.e007621.11","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P900020-JLR200"},{"key":"2024051513442533000_5.6.e007621.12","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.842"},{"key":"2024051513442533000_5.6.e007621.13","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700399-JLR200"},{"key":"2024051513442533000_5.6.e007621.14","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp145"},{"key":"2024051513442533000_5.6.e007621.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.04.004"},{"key":"2024051513442533000_5.6.e007621.16","doi-asserted-by":"crossref","first-page":"9879","DOI":"10.1007\/s11033-012-1854-y","article-title":"The association between endothelial lipase -384A\/C gene polymorphism and acute coronary syndrome in a Chinese population","volume":"39","author":"Cai","year":"2012","journal-title":"Mol Biol Rep"},{"key":"2024051513442533000_5.6.e007621.17","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1089\/gtmb.2014.0195","article-title":"Endothelial lipase-384A\/C polymorphism is associated with acute coronary syndrome and lipid status in elderly Uygur patients in Xinjiang","volume":"18","author":"Huang","year":"2014","journal-title":"Genet Test Mol Biomarkers"},{"key":"2024051513442533000_5.6.e007621.18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1476-511X-13-85","article-title":"The associations between endothelial lipase 584C\/T polymorphism and HDL-C level and coronary heart disease susceptibility: a meta-analysis","volume":"13","author":"Cai","year":"2014","journal-title":"Lipids Health Dis"},{"key":"2024051513442533000_5.6.e007621.19","unstructured":"Terwilliger JD , Ott J . 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