{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:53:19Z","timestamp":1790715199189,"version":"4.1.0"},"reference-count":31,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,10,29]]},"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess contemporary data on characteristics, management and 1-year postdischarge outcomes in Iranian patients hospitalised with acute coronary syndrome (ACS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>11 tertiary care hospitals in 5 major cities in the Islamic Republic of Iran.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients aged \u226520 and \u226480\u2005years discharged alive with confirmed diagnosis of ACS including ST-segment elevation myocardial infarction (STEMI), non-STEMI (NSTEMI) and high-risk unstable angina (HR-UA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Patients were followed up regarding the use of medications and the end points of the study at 1\u2005month and 1\u2005year after discharge. The primary end point of the study was 1-year postdischarge major adverse cardiac and cerebrovascular events (MACCEs), defined as mortality (cardiac and non-cardiac), ACS and cerebrovascular attack (stroke and\/or transient ischaemic attack). The secondary end points were hospital admission because of congestive heart failure, revascularisation by coronary artery bypass grafting surgery or percutaneous coronary intervention (PCI), and major and minor bleeds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1799 patients (25.7% STEMI and 74.3% HR-UA\/NSTEMI) discharged alive with confirmed diagnosis of ACS were included in the final analysis. During hospitalisation, the majority of the patients received aspirin (98.6%), clopidogrel (91.8%), anticoagulants (93.4%), statins (94.3%) and \u03b2-blockers (89.3%). Reperfusion therapy was performed in 62.6% of patients with STEMI (46.3% thrombolytic therapy and 17.3% primary PCI). The mean door-to-balloon and door-to-needle times were 82.9 and 45.6\u2005min, respectively. In our study, 64.7% and 79.5% of the patients in HR-UA\/NSTEMI and STEMI groups, respectively, underwent coronary angiography. During the 12\u2005months after discharge, MACCEs occurred in 15.0% of all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study showed that the composition of Iranian patients with ACS regarding the type of ACS is similar to that in developed European countries and is unlike that in developing countries of the Middle East and Africa. We found that our patients with ACS are treated with high levels of adherence to guideline-recommended in-hospital medications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-007786","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T21:45:01Z","timestamp":1450215901000},"page":"e007786","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Clinical characteristics, management and 1-year outcomes of patients with acute coronary syndrome in Iran: the Iranian Project for Assessment of Coronary Events 2 (IPACE2)"],"prefix":"10.1136","volume":"5","author":[{"given":"Seyed Ebrahim","family":"Kassaian","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzad","family":"Masoudkabir","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashem","family":"Sezavar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rasul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Javad-Al-Aemmeh Heart Hospital & Research Center, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Pourmoghaddas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Khorshid Hospital, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Kojouri","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samad","family":"Ghaffari","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Sanaati","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshid","family":"Alaeddini","sequence":"additional","affiliation":[{"name":"Department of Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahin","family":"Pourmirza","sequence":"additional","affiliation":[{"name":"Sanofi Iran Medical Department, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Mir","sequence":"additional","affiliation":[{"name":"Sanofi Iran Medical Department, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,12,15]]},"reference":[{"key":"2025121601350659000_5.12.e007786.1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl196"},{"key":"2025121601350659000_5.12.e007786.2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1047"},{"key":"2025121601350659000_5.12.e007786.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31820f2f3e"},{"key":"2025121601350659000_5.12.e007786.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192663"},{"key":"2025121601350659000_5.12.e007786.5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr236"},{"key":"2025121601350659000_5.12.e007786.6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn416"},{"key":"2025121601350659000_5.12.e007786.7","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2002.3193"},{"key":"2025121601350659000_5.12.e007786.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00509-X"},{"key":"2025121601350659000_5.12.e007786.9","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.3081"},{"key":"2025121601350659000_5.12.e007786.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.09.012"},{"key":"2025121601350659000_5.12.e007786.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02489-X"},{"key":"2025121601350659000_5.12.e007786.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11162-X"},{"key":"2025121601350659000_5.12.e007786.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00315-4"},{"key":"2025121601350659000_5.12.e007786.14","first-page":"861","article-title":"Polish Registry of Acute Coronary Syndromes (PL-ACS). Characteristics, treatments and outcomes of patients with acute coronary syndromes in Poland","volume":"65","author":"Polonski","year":"2007","journal-title":"Kardiol Pol"},{"key":"2025121601350659000_5.12.e007786.15","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1445-5994.2007.01435.x","article-title":"Current management of acute coronary syndromes in Australia: observations from the acute coronary syndromes prospective audit","volume":"37","author":"Chew","year":"2007","journal-title":"Intern Med J"},{"key":"2025121601350659000_5.12.e007786.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.06.003"},{"key":"2025121601350659000_5.12.e007786.17","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-0174"},{"key":"2025121601350659000_5.12.e007786.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60623-6"},{"key":"2025121601350659000_5.12.e007786.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.07.029"},{"key":"2025121601350659000_5.12.e007786.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsha.2011.05.004"},{"key":"2025121601350659000_5.12.e007786.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.07.029"},{"key":"2025121601350659000_5.12.e007786.22","first-page":"1465","article-title":"Portuguese Registry of Acute Coronary Syndromes: seven years of activity","volume":"28","author":"Santos","year":"2009","journal-title":"Rev Port Cardiol"},{"key":"2025121601350659000_5.12.e007786.23","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn069"},{"key":"2025121601350659000_5.12.e007786.24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5144\/0256-4947.2012.9","article-title":"Baseline characteristics, management practices, and long-term outcomes of Middle Eastern patients in the Second Gulf Registry of Acute Coronary Events (Gulf RACE-2)","volume":"32","author":"Alhabib","year":"2012","journal-title":"Ann Saudi Med"},{"key":"2025121601350659000_5.12.e007786.25","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijcard.2008.12.129","article-title":"Management of acute coronary syndromes in developing countries: are we complying with practice guidelines?","volume":"144","author":"Karrowni","year":"2010","journal-title":"Int J Cardiol"},{"key":"2025121601350659000_5.12.e007786.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.07.028"},{"key":"2025121601350659000_5.12.e007786.27","first-page":"508","article-title":"Malaysia-ACute CORonary syndromes Descriptive study (ACCORD): evaluation of compliance with existing guidelines in patients with acute coronary syndrome","volume":"52","author":"Ahmad","year":"2011","journal-title":"Singapore Med J"},{"key":"2025121601350659000_5.12.e007786.28","doi-asserted-by":"crossref","first-page":"E40","DOI":"10.1002\/clc.20730","article-title":"The causes and outcomes of inadequate implementation of existing guidelines for antiplatelet treatment in patients with acute coronary syndrome: the experience from Taiwan Acute Coronary Syndrome Descriptive Registry (T-ACCORD Registry)","volume":"33","author":"Cheng","year":"2010","journal-title":"Clin Cardiol"},{"key":"2025121601350659000_5.12.e007786.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.01.020"},{"key":"2025121601350659000_5.12.e007786.30","first-page":"249","article-title":"A cohort study of risk factors and clinical outcome predictors for patients presenting with unstable angina and non ST segment elevation myorardial infraction undergoing coronary intervention","volume":"66","author":"Chong","year":"2011","journal-title":"Med J Malaysia"},{"key":"2025121601350659000_5.12.e007786.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.08.132"}],"updated-by":[{"DOI":"10.1136\/bmjopen-2015-007786corr1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000}},{"DOI":"10.1136\/bmjopen-2015-007786corr2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000}}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2015-007786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T09:35:14Z","timestamp":1765877714000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2015-007786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":31,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,15]]},"published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1136\/bmjopen-2015-007786"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2015-007786","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}