{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:21:22Z","timestamp":1793715682651,"version":"4.6.1"},"reference-count":98,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,2,9]]},"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To derive and validate a set of clinical risk prediction algorithm to estimate the 10-year risk of 11 common cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective open cohort study using routinely collected data from 753 QResearch general practices in England. We used 565 practices to develop the scores and 188 for validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>4.96 million patients aged 25\u201384\u2005years in the derivation cohort; 1.64 million in the validation cohort. Patients were free of the relevant cancer at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cox proportional hazards models in the derivation cohort to derive 10-year risk algorithms. Risk factors considered included age, ethnicity, deprivation, body mass index, smoking, alcohol, previous cancer diagnoses, family history of cancer, relevant comorbidities and medication. Measures of calibration and discrimination in the validation cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes<\/jats:title>\n                    <jats:p>Incident cases of blood, breast, bowel, gastro-oesophageal, lung, oral, ovarian, pancreas, prostate, renal tract and uterine cancers. Cancers were recorded on any one of four linked data sources (general practitioner (GP), mortality, hospital or cancer records).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 228\u2005241 incident cases during follow-up of the 11 types of cancer. Of these 25\u2005444 were blood; 41\u2005315 breast; 32\u2005626 bowel, 12\u2005808 gastro-oesophageal; 32\u2005187 lung; 4811 oral; 6635 ovarian; 7119 pancreatic; 35\u2005256 prostate; 23\u2005091 renal tract; 6949 uterine cancers. The lung cancer algorithm had the best performance with an R\n                      <jats:sup>2<\/jats:sup>\n                      of 64.2%; D statistic of 2.74; receiver operating characteristic curve statistic of 0.91 in women. The sensitivity for the top 10% of women at highest risk of lung cancer was 67%. Performance of the algorithms in men was very similar to that for women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We have developed and validated a prediction models to quantify absolute risk of 11 common cancers. They can be used to identify patients at high risk of cancers for prevention or further assessment. The algorithms could be integrated into clinical computer systems and used to identify high-risk patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Web calculator:<\/jats:title>\n                    <jats:p>\n                      There is a simple web calculator to implement the Qcancer 10 year risk algorithm together with the open source software for download (available at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/qcancer.org\/10yr\/\" ext-link-type=\"uri\">http:\/\/qcancer.org\/10yr\/<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-007825","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T22:33:31Z","timestamp":1426631611000},"page":"e007825","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":153,"title":["Development and validation of risk prediction algorithms to estimate future risk of common cancers in men and women: prospective cohort study"],"prefix":"10.1136","volume":"5","author":[{"given":"Julia","family":"Hippisley-Cox","sequence":"first","affiliation":[{"name":"Division of Primary Care, University Park, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Coupland","sequence":"additional","affiliation":[{"name":"Division of Primary Care, University Park, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,3,17]]},"reference":[{"key":"2025121300174650000_5.3.e007825.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70245-0"},{"key":"2025121300174650000_5.3.e007825.2","unstructured":"Department of Health. The Cancer Reform Strategy. In: Health Do, ed. London: Department of Health, 2007."},{"key":"2025121300174650000_5.3.e007825.3","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp11X606609"},{"key":"2025121300174650000_5.3.e007825.4","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp11X606627"},{"key":"2025121300174650000_5.3.e007825.5","doi-asserted-by":"crossref","unstructured":"Hippisley-Cox J , Coupland C . Identifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm. BMJ 2012;344.","DOI":"10.1136\/bmj.d8009"},{"key":"2025121300174650000_5.3.e007825.6","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp12X616346"},{"key":"2025121300174650000_5.3.e007825.7","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp12X616355"},{"key":"2025121300174650000_5.3.e007825.8","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp12X636074"},{"key":"2025121300174650000_5.3.e007825.9","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp13X660661"},{"key":"2025121300174650000_5.3.e007825.10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3399\/bjgp13X660724","article-title":"Symptoms and risk factors to identify men with suspected cancer in primary care: derivation and validation of an algorithm","volume":"63","author":"Hippisley-Cox","year":"2013","journal-title":"Br J Gen Pract"},{"key":"2025121300174650000_5.3.e007825.11","unstructured":"Office for National Statistics. Ten most common cancers among males and females. 2014. http:\/\/www.ons.gov.uk\/ons\/rel\/vsob1\/cancer-statistics-registrations\u2013england\u2013series-mb1-\/no\u201343\u20132012\/info-most-common-cancers.html"},{"key":"2025121300174650000_5.3.e007825.12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003482"},{"key":"2025121300174650000_5.3.e007825.13","unstructured":"Hippisley-Cox J . Validity and completeness of the NHS Number in primary and secondary care electronic data in England 1991\u20132013. 2013;1. Hippisley-Cox J. Validity and completeness of the NHS number in primary and secondary care: electronic data in England 1991\u20132013. http:\/\/eprints.nottingham.ac.uk\/3153\/ (accessed Jun 2013)."},{"key":"2025121300174650000_5.3.e007825.14","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.12.1368"},{"key":"2025121300174650000_5.3.e007825.15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2197"},{"key":"2025121300174650000_5.3.e007825.16","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.199034"},{"key":"2025121300174650000_5.3.e007825.17","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.252"},{"key":"2025121300174650000_5.3.e007825.18","unstructured":"Cancer Research UK. Cancer Research Website. 2014. http:\/\/www.cancerresearchuk.org\/ (accessed 30th Jul 2014)."},{"key":"2025121300174650000_5.3.e007825.19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39609.449676.25"},{"key":"2025121300174650000_5.3.e007825.20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39261.471806.55"},{"key":"2025121300174650000_5.3.e007825.21","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.134890"},{"key":"2025121300174650000_5.3.e007825.22","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2584"},{"key":"2025121300174650000_5.3.e007825.23","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.7.2.147"},{"key":"2025121300174650000_5.3.e007825.24","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6673.573"},{"key":"2025121300174650000_5.3.e007825.25","first-page":"979","article-title":"Imputation is beneficial for handling missing data in predictive models","volume":"60","author":"Steyerberg","year":"2007","journal-title":"J Epidemiol Community Health"},{"key":"2025121300174650000_5.3.e007825.26","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2005.036897"},{"key":"2025121300174650000_5.3.e007825.27","doi-asserted-by":"crossref","unstructured":"Rubin DB . Multiple imputation for non-response in surveys. New York: John Wiley, 1987.","DOI":"10.1002\/9780470316696"},{"key":"2025121300174650000_5.3.e007825.28","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.5.964"},{"key":"2025121300174650000_5.3.e007825.29","doi-asserted-by":"crossref","unstructured":"Hosmer D , Lemeshow S . Applied logistic regression. New York: John Wiley & Sons, Inc., 1989.","DOI":"10.2307\/2531779"},{"key":"2025121300174650000_5.3.e007825.30","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-005809"},{"key":"2025121300174650000_5.3.e007825.31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1536867X0600600105","article-title":"Explained variation for survival models","volume":"6","author":"Royston","year":"2006","journal-title":"Stata J"},{"key":"2025121300174650000_5.3.e007825.32","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1621"},{"key":"2025121300174650000_5.3.e007825.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.02.016"},{"key":"2025121300174650000_5.3.e007825.34","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm051"},{"key":"2025121300174650000_5.3.e007825.35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/030089160909500103","article-title":"Smoking status and gastric cancer risk: an updated meta-analysis of case-control studies published in the past ten years","volume":"95","author":"La Torre","year":"2009","journal-title":"Tumori"},{"key":"2025121300174650000_5.3.e007825.36","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6959.901"},{"key":"2025121300174650000_5.3.e007825.37","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.489"},{"key":"2025121300174650000_5.3.e007825.38","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr541"},{"key":"2025121300174650000_5.3.e007825.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.08.014"},{"key":"2025121300174650000_5.3.e007825.40","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20821"},{"key":"2025121300174650000_5.3.e007825.41","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn514"},{"key":"2025121300174650000_5.3.e007825.42","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600596"},{"key":"2025121300174650000_5.3.e007825.43","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24393"},{"key":"2025121300174650000_5.3.e007825.44","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2003.04232.x"},{"key":"2025121300174650000_5.3.e007825.45","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970529)71:5<800::AID-IJC18>3.0.CO;2-B"},{"key":"2025121300174650000_5.3.e007825.46","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06524-2"},{"key":"2025121300174650000_5.3.e007825.47","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/64.1.27"},{"key":"2025121300174650000_5.3.e007825.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.09.023"},{"key":"2025121300174650000_5.3.e007825.49","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/j.ejca.2012.01.038","article-title":"Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium","volume":"48","author":"Cote","year":"2012","journal-title":"Eur J Cancer"},{"key":"2025121300174650000_5.3.e007825.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2010.03.001"},{"key":"2025121300174650000_5.3.e007825.51","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/sj.bjc.6604135","article-title":"Population attributable fractions for ovarian cancer in Swedish women by morphological type","volume":"98","author":"Granstrom","year":"2008","journal-title":"Br J Cancer"},{"key":"2025121300174650000_5.3.e007825.52","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90806-5"},{"key":"2025121300174650000_5.3.e007825.53","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14065-2"},{"key":"2025121300174650000_5.3.e007825.54","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt043"},{"key":"2025121300174650000_5.3.e007825.55","doi-asserted-by":"crossref","unstructured":"Havrilesky LJ , Gierisch JM , Moorman PG , et al . Oral contraceptive use for the primary prevention of ovarian cancer. Evid Rep Technol Assess (Full Rep) 2013 (212):1\u2013514.","DOI":"10.1097\/AOG.0b013e318291c235"},{"key":"2025121300174650000_5.3.e007825.56","doi-asserted-by":"crossref","unstructured":"Salehi F , Dunfield L , Phillips KP , et al . Risk factors for ovarian cancer: an overview with emphasis on hormonal factors. J Toxicol Environ Health B Crit Rev 2008;11:301\u201321.","DOI":"10.1080\/10937400701876095"},{"key":"2025121300174650000_5.3.e007825.57","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31828029c0"},{"key":"2025121300174650000_5.3.e007825.58","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12651"},{"key":"2025121300174650000_5.3.e007825.59","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103042"},{"key":"2025121300174650000_5.3.e007825.60","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds140"},{"key":"2025121300174650000_5.3.e007825.61","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00432-011-0979-z","article-title":"The influence of family history and histological stratification on breast cancer risk in women with benign breast disease: a meta-analysis","volume":"137","author":"Zhou","year":"2011","journal-title":"J Cancer Res Clin Oncol"},{"key":"2025121300174650000_5.3.e007825.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.08.1061"},{"key":"2025121300174650000_5.3.e007825.63","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13409-5"},{"key":"2025121300174650000_5.3.e007825.64","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-011-9617-y"},{"key":"2025121300174650000_5.3.e007825.65","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.ejca.2011.07.010","article-title":"Type 2 diabetes mellitus and colorectal cancer: meta-analysis on sex-specific differences","volume":"48","author":"Kramer","year":"2012","journal-title":"Eur J Cancer"},{"key":"2025121300174650000_5.3.e007825.66","doi-asserted-by":"crossref","unstructured":"Luo W , Cao Y , Liao C , et al . Diabetes mellitus and the incidence and mortality of colorectal cancer: a meta-analysis of twenty four cohort studies. Colorectal Dis 2011; doi:10.1111\/j.1463-1318.2011.02875.x.","DOI":"10.1111\/j.1463-1318.2011.02875.x"},{"key":"2025121300174650000_5.3.e007825.67","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1089\/dia.2012.0263","article-title":"Diabetes mellitus and the occurrence of colorectal cancer: an updated meta-analysis of cohort studies","volume":"15","author":"Wu","year":"2013","journal-title":"Diabetes Technol Ther"},{"key":"2025121300174650000_5.3.e007825.68","doi-asserted-by":"crossref","first-page":"6902","DOI":"10.3748\/wjg.v19.i40.6902","article-title":"Diabetes mellitus carries a risk of gastric cancer: a meta-analysis","volume":"19","author":"Shimoyama","year":"2013","journal-title":"WJG"},{"key":"2025121300174650000_5.3.e007825.69","doi-asserted-by":"publisher","DOI":"10.2174\/15748863113086660071"},{"key":"2025121300174650000_5.3.e007825.70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.03.003"},{"key":"2025121300174650000_5.3.e007825.71","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e31827b8430"},{"issue":"(Suppl 1)","key":"2025121300174650000_5.3.e007825.72","doi-asserted-by":"crossref","first-page":"S235","DOI":"10.1007\/s00592-012-0439-5","article-title":"Diabetes mellitus and risk of prostate cancer: an updated meta-analysis based on 12 case-control and 25 cohort studies","volume":"49","author":"Zhang","year":"2012","journal-title":"Acta Diabetol"},{"key":"2025121300174650000_5.3.e007825.73","doi-asserted-by":"crossref","first-page":"441","DOI":"10.7314\/APJCP.2013.14.1.441","article-title":"Diabetes mellitus reduces prostate cancer risk\u2014no function of age at diagnosis or duration of disease","volume":"14","author":"Xu","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"2025121300174650000_5.3.e007825.74","unstructured":"UK CR. Cancer incidence and survival by major ethnic group in England, 2002\u20132006. Secondary Cancer incidence and survival by major ethnic group in England, 2002\u20132006. 2009. http:\/\/publications.cancerresearchuk.org\/cancerstats\/statssurvival\/incidence-survival-ethnicity.html.html"},{"key":"2025121300174650000_5.3.e007825.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.02.047"},{"key":"2025121300174650000_5.3.e007825.76","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-83"},{"key":"2025121300174650000_5.3.e007825.77","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1471-2407-14-94","article-title":"The effect of patient characteristics on second primary cancer risk in France","volume":"14","author":"Jegu","year":"2014","journal-title":"BMC Cancer"},{"key":"2025121300174650000_5.3.e007825.78","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.09.038"},{"key":"2025121300174650000_5.3.e007825.79","unstructured":"National Clinical Guideline Centre. Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease. London 2014:286."},{"key":"2025121300174650000_5.3.e007825.80","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b880"},{"key":"2025121300174650000_5.3.e007825.81","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e3427"},{"key":"2025121300174650000_5.3.e007825.82","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-11-49"},{"key":"2025121300174650000_5.3.e007825.83","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d4656"},{"key":"2025121300174650000_5.3.e007825.84","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4229"},{"key":"2025121300174650000_5.3.e007825.85","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d3651"},{"key":"2025121300174650000_5.3.e007825.86","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03237.x"},{"key":"2025121300174650000_5.3.e007825.87","first-page":"5","article-title":"Sources, uses, strengths and limitations of data collected in primary care in England","volume":"21","author":"Majeed","year":"2004","journal-title":"Health Stat Q"},{"key":"2025121300174650000_5.3.e007825.88","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4181"},{"key":"2025121300174650000_5.3.e007825.89","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2442"},{"key":"2025121300174650000_5.3.e007825.90","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907727"},{"key":"2025121300174650000_5.3.e007825.91","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260825"},{"key":"2025121300174650000_5.3.e007825.92","unstructured":"Hippisley-Cox J , Coupland C . QRISK2\u20132014 Annual Update Information, 2014:5."},{"key":"2025121300174650000_5.3.e007825.93","unstructured":"Hippisley-Cox J . QDiabetes 2013 Annual Update Information Secondary QDiabetes 2013 Annual Update Information 2013. http:\/\/qdiabetes.org\/QDiabetes-2013-Annual-Update-Information.pdf"},{"key":"2025121300174650000_5.3.e007825.94","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f2573"},{"key":"2025121300174650000_5.3.e007825.95","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4606"},{"key":"2025121300174650000_5.3.e007825.96","first-page":"CD000165","article-title":"Physician advice for smoking cessation","volume":"5","author":"Stead","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"2025121300174650000_5.3.e007825.97","doi-asserted-by":"crossref","unstructured":"Kaner EF , Beyer F , Dickinson HO , et al . Effectiveness of brief alcohol interventions in primary care populations. Cochrane Database Syst Rev 2007 (2):CD004148.","DOI":"10.1002\/14651858.CD004148.pub3"},{"key":"2025121300174650000_5.3.e007825.98","doi-asserted-by":"crossref","unstructured":"Parkes G , Greenhalgh T , Griffin M , et al . Effect on smoking quit rate of telling patients their lung age: the Step2quit randomised controlled trial. BMJ 2008;336:598\u2013600.","DOI":"10.1136\/bmj.39503.582396.25"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2015-007825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T08:17:55Z","timestamp":1765613875000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2015-007825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":98,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,17]]},"published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1136\/bmjopen-2015-007825"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2015-007825","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}