{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:36:00Z","timestamp":1778679360320,"version":"3.51.4"},"reference-count":71,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,4,26]]},"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Venous thromboembolism (VTE) with its two manifestations deep vein thrombosis (DVT) and pulmonary embolism (PE) is a major public health problem. The\n                      <jats:italic>VTEval Project<\/jats:italic>\n                      aims to investigate numerous research questions on diagnosis, clinical management, treatment and prognosis of VTE, which have remained uncertain to date.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>VTEval Project<\/jats:italic>\n                      consists of three observational, prospective cohort studies on VTE comprising cohorts of individuals with a clinical suspicion of acute PE (with or without DVT), with a clinical suspicion of acute DVT (without symptomatic PE) and with an incidental diagnosis of VTE (PE or DVT). The\n                      <jats:italic>VTEval Project<\/jats:italic>\n                      expects to enrol a total of approximately 2000 individuals with subsequent active and passive follow-up investigations over a time period of 5\u2005years per participant. Time points for active follow-up investigations are at months 3, 6, 12, 24 and 36 after diagnosis (depending on the disease cohort); passive follow-up investigations via registry offices and the cancer registry are performed 48 and 60\u2005months after diagnosis for all participants. Primary short-term outcome is defined by overall mortality (PE-related death and all other causes of death), primary long-term outcome by symptomatic VTE (PE-related death, recurrence of non-fatal PE or DVT). The\n                      <jats:italic>VTEval Project<\/jats:italic>\n                      includes three \u2018all-comer\u2019 studies and involves the standardised acquisition of high-quality data, covering the systematic assessment of VTE including symptoms, risk profile, psychosocial, environmental and lifestyle factors as well as clinical and subclinical disease, and it builds up a large state-of-the-art biorepository containing various materials from serial blood samplings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>VTEval Project<\/jats:italic>\n                      has been approved by the local data safety commissioner and the responsible ethics committee (reference no. 837.320.12 (8421-F)). Trial results will be published in peer-reviewed journals and presented at national and international scientific meetings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>NCT02156401.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-008157","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T22:59:55Z","timestamp":1435791595000},"page":"e008157","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Rationale and design of three observational, prospective cohort studies including biobanking to evaluate and improve diagnostics, management strategies and risk stratification in venous thromboembolism: the\n                    <i>VTEval Project<\/i>"],"prefix":"10.1136","volume":"5","author":[{"given":"Bernd","family":"Frank","sequence":"first","affiliation":[{"name":"Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liana","family":"Ariza","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidrun","family":"Lamparter","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Grossmann","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen H","family":"Prochaska","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany"},{"name":"Department of Medicine 2, University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Ullmann","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florentina","family":"Kindler","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Weisser","sequence":"additional","affiliation":[{"name":"Department of Medicine 2, University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Walter","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl J","family":"Lackner","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Espinola-Klein","sequence":"additional","affiliation":[{"name":"Department of Medicine 2, University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"M\u00fcnzel","sequence":"additional","affiliation":[{"name":"Department of Medicine 2, University Medical Center Mainz, Mainz, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site RhineMain, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stavros V","family":"Konstantinides","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp S","family":"Wild","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany"},{"name":"Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center Mainz, Mainz, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site RhineMain, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"2025121508562133000_5.7.e008157.1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1160\/TH07-03-0212","article-title":"Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality","volume":"98","author":"Cohen","year":"2007","journal-title":"Thromb Haemost"},{"key":"2025121508562133000_5.7.e008157.2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000441139.02102.80"},{"key":"2025121508562133000_5.7.e008157.3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.6.585"},{"issue":"(23 Suppl 1)","key":"2025121508562133000_5.7.e008157.4","first-page":"I4","article-title":"The epidemiology of venous thromboembolism","volume":"107","author":"White","year":"2003","journal-title":"Circulation"},{"key":"2025121508562133000_5.7.e008157.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032274"},{"key":"2025121508562133000_5.7.e008157.6","first-page":"363","article-title":"All-cause and potentially disease-related health care costs associated with venous thromboembolism in commercial, Medicare, and Medicaid beneficiaries","volume":"18","author":"Lefebvre","year":"2012","journal-title":"J Manag Care Pharm"},{"key":"2025121508562133000_5.7.e008157.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2010.10.005"},{"key":"2025121508562133000_5.7.e008157.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.65"},{"key":"2025121508562133000_5.7.e008157.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)08140-3"},{"key":"2025121508562133000_5.7.e008157.10","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1055\/s-0037-1613830","article-title":"Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer","volume":"83","author":"Wells","year":"2000","journal-title":"Thromb Haemost"},{"key":"2025121508562133000_5.7.e008157.11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.911438"},{"key":"2025121508562133000_5.7.e008157.12","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2011.165134"},{"key":"2025121508562133000_5.7.e008157.13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.15288\/jsa.2003.64.75","article-title":"Distribution and dose response of laboratory markers to alcohol consumption in a general population: results of the study of health in Pomerania (SHIP)","volume":"64","author":"Alte","year":"2003","journal-title":"J Stud Alcohol"},{"key":"2025121508562133000_5.7.e008157.14","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-012-1502-7"},{"key":"2025121508562133000_5.7.e008157.15","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-828376"},{"key":"2025121508562133000_5.7.e008157.16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF02884962","article-title":"Personality and coronary heart disease: the type-D scale-16 (DS16)","volume":"20","author":"Denollet","year":"1998","journal-title":"Ann Behav Med"},{"key":"2025121508562133000_5.7.e008157.17","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-5-200703060-00004"},{"key":"2025121508562133000_5.7.e008157.18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"2025121508562133000_5.7.e008157.19","doi-asserted-by":"publisher","DOI":"10.1002\/da.1055"},{"key":"2025121508562133000_5.7.e008157.20","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200203000-00008"},{"key":"2025121508562133000_5.7.e008157.21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/s-0029-1224098","article-title":"Screening for depersonalization-derealization with two items of the cambridge depersonalization scale","volume":"60","author":"Michal","year":"2010","journal-title":"Psychother Psychosom Med Psychol"},{"key":"2025121508562133000_5.7.e008157.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00220-8"},{"key":"2025121508562133000_5.7.e008157.23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03726.x"},{"key":"2025121508562133000_5.7.e008157.24","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1477-7525-10-120","article-title":"The Anti-Clot Treatment Scale (ACTS) in clinical trials: cross-cultural validation in venous thromboembolism patients","volume":"10","author":"Cano","year":"2012","journal-title":"Health Qual Life Outcomes"},{"key":"2025121508562133000_5.7.e008157.25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1160\/TH13-09-0793","article-title":"Epidemiology of first and recurrent venous thromboembolism: a population-based cohort study in patients without active cancer","volume":"112","author":"Martinez","year":"2014","journal-title":"Thromb Haemost"},{"key":"2025121508562133000_5.7.e008157.26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.thromres.2014.12.024","article-title":"Long-term increased factor VIII levels are associated to interleukin-6 levels but not to post-thrombotic syndrome in patients with deep venous thrombosis","volume":"135","author":"Bittar","year":"2015","journal-title":"Thromb Res"},{"key":"2025121508562133000_5.7.e008157.27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/MBC.0000000000000164","article-title":"Comprehensive study on laboratory biomarkers for prediction and diagnosis of deep venous thrombosis","volume":"26","author":"Ghozlan","year":"2015","journal-title":"Blood Coagul Fibrinolysis"},{"key":"2025121508562133000_5.7.e008157.28","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.198473"},{"key":"2025121508562133000_5.7.e008157.29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1160\/TH09-04-0274","article-title":"C-reactive protein and venous thromboembolism. A prospective investigation in the ARIC cohort","volume":"102","author":"Folsom","year":"2009","journal-title":"Thromb Haemostasis"},{"key":"2025121508562133000_5.7.e008157.30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140917319"},{"key":"2025121508562133000_5.7.e008157.31","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.42"},{"key":"2025121508562133000_5.7.e008157.32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.carpath.2014.03.009","article-title":"The up-regulation of endothelin-1 and down-regulation of miRNA-125a-5p, -155, and -199a\/b-3p in human atherosclerotic coronary artery","volume":"23","author":"Hao","year":"2014","journal-title":"Cardiovasc Pathol"},{"key":"2025121508562133000_5.7.e008157.33","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.241109"},{"key":"2025121508562133000_5.7.e008157.34","doi-asserted-by":"publisher","DOI":"10.1177\/1076029611405032"},{"key":"2025121508562133000_5.7.e008157.35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jvsv.2012.09.001","article-title":"Soluble P-selectin for the diagnosis of lower extremity deep venous thrombosis","volume":"1","author":"Vandy","year":"2013","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"2025121508562133000_5.7.e008157.36","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/jth.12814","article-title":"Inflammation markers and their trajectories after deep vein thrombosis in relation to risk of postthrombotic syndrome","volume":"13","author":"Rabinovich","year":"2015","journal-title":"J Thromb Haemost"},{"key":"2025121508562133000_5.7.e008157.37","doi-asserted-by":"publisher","DOI":"10.1177\/2047487314527852"},{"key":"2025121508562133000_5.7.e008157.38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.5482\/HAMO-13-06-0029","article-title":"Diagnosis of recurrent deep vein thrombosis","volume":"33","author":"Schellong","year":"2013","journal-title":"Hamostaseologie"},{"key":"2025121508562133000_5.7.e008157.39","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11239-012-0721-y","article-title":"Biomarkers of deep venous thrombosis","volume":"34","author":"Hou","year":"2012","journal-title":"J Thromb Thrombolysis"},{"key":"2025121508562133000_5.7.e008157.40","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1093\/eurheartj\/ehu243","article-title":"Management of venous thrombo-embolism: an update","volume":"35","author":"Konstantinides","year":"2014","journal-title":"Eur Heart J"},{"key":"2025121508562133000_5.7.e008157.41","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu283"},{"key":"2025121508562133000_5.7.e008157.42","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hci085"},{"key":"2025121508562133000_5.7.e008157.43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04895.x"},{"key":"2025121508562133000_5.7.e008157.44","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-07-0511"},{"key":"2025121508562133000_5.7.e008157.45","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-011-0840-5"},{"key":"2025121508562133000_5.7.e008157.46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-0037-1617146","article-title":"Inflammation, innate immunity and blood coagulation","volume":"30","author":"Xu","year":"2010","journal-title":"Hamostaseologie"},{"issue":"(Suppl 1)","key":"2025121508562133000_5.7.e008157.47","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1538-7836.2011.04311.x","article-title":"Lessons from genome-wide association studies in venous thrombosis","volume":"9","author":"Morange","year":"2011","journal-title":"J Thromb Haemost"},{"key":"2025121508562133000_5.7.e008157.48","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000341"},{"key":"2025121508562133000_5.7.e008157.49","doi-asserted-by":"crossref","first-page":"115","DOI":"10.5482\/HAMO-13-08-0041","article-title":"Biomarkers for arterial and venous thrombotic disorders","volume":"34","author":"Mannhalter","year":"2014","journal-title":"Hamostaseologie"},{"key":"2025121508562133000_5.7.e008157.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.01.019"},{"key":"2025121508562133000_5.7.e008157.51","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03886.x"},{"key":"2025121508562133000_5.7.e008157.52","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-014-0119-7"},{"key":"2025121508562133000_5.7.e008157.53","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-12-512681"},{"key":"2025121508562133000_5.7.e008157.54","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/MOH.0b013e328363c170","article-title":"Treatment with novel oral anticoagulants: indications, efficacy and risks","volume":"20","author":"Ghanny","year":"2013","journal-title":"Curr Opin Hematol"},{"key":"2025121508562133000_5.7.e008157.55","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2301"},{"key":"2025121508562133000_5.7.e008157.56","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1108\/09526861211261217","article-title":"Implementing NICE guidelines on risk assessment for venous thromboembolism: failure, success and controversy","volume":"25","author":"Thavarajah","year":"2012","journal-title":"Int J Health Care Qual Assur"},{"key":"2025121508562133000_5.7.e008157.57","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007903"},{"key":"2025121508562133000_5.7.e008157.58","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302507"},{"key":"2025121508562133000_5.7.e008157.59","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12230"},{"key":"2025121508562133000_5.7.e008157.60","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004450"},{"key":"2025121508562133000_5.7.e008157.61","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.jvs.2013.11.091","article-title":"Home versus in-hospital treatment of outpatients with acute deep venous thrombosis of the lower limbs","volume":"59","author":"Lozano","year":"2014","journal-title":"J Vasc Surg"},{"key":"2025121508562133000_5.7.e008157.62","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04388.x"},{"key":"2025121508562133000_5.7.e008157.63","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2299"},{"key":"2025121508562133000_5.7.e008157.64","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.080493"},{"key":"2025121508562133000_5.7.e008157.65","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7462-0"},{"key":"2025121508562133000_5.7.e008157.66","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2013.1.457"},{"key":"2025121508562133000_5.7.e008157.67","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/MCP.0b013e328363ed7c","article-title":"Assessing recurrence risk following acute venous thromboembolism: use of algorithms","volume":"19","author":"Poli","year":"2013","journal-title":"Curr Opin Pulm Med"},{"key":"2025121508562133000_5.7.e008157.68","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/ejh.12002","article-title":"Anticoagulant treatment of pulmonary embolism: impact and implications of the EINSTEIN PE study","volume":"89","author":"Prandoni","year":"2012","journal-title":"Eur J Haematol"},{"key":"2025121508562133000_5.7.e008157.69","doi-asserted-by":"publisher","DOI":"10.4103\/2045-8932.114761"},{"key":"2025121508562133000_5.7.e008157.70","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-07-0538"},{"key":"2025121508562133000_5.7.e008157.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.024"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2015-008157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T16:56:29Z","timestamp":1765817789000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2015-008157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":71,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,1]]},"published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1136\/bmjopen-2015-008157"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2015-008157","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}