{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:09:45Z","timestamp":1790665785169,"version":"4.1.0"},"reference-count":29,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,10,26]]},"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate if there is evidence on effectiveness of progressive resistance training in rehabilitation of Parkinson disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Systematic review and meta-analysis. Data sources: Central, Medline, Embase, Cinahl, Web of Science, Pedro until May 2014. Randomised controlled or controlled clinical trials. The methodological quality of studies was assessed according to the Cochrane Collaboration's domain-based evaluation framework. Data synthesis: random effects meta-analysis with test for heterogeneity using the I\u00b2 and pooled estimate as the raw mean difference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Adults with primary\/idiopathic Parkinson's disease of any severity, excluding other concurrent neurological condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Progressive resistance training defined as training consisting of a small number of repetitions until fatigue, allowing sufficient rest between exercises for recovery, and increasing the resistance as the ability to generate force improves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Comparison<\/jats:title>\n                    <jats:p>Progressive resistance training versus no treatment, placebo or other treatment in randomised controlled or controlled clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Any outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 516 records, 12 were considered relevant. Nine of them had low risk of bias. All studies were randomised controlled trials conducted on small samples with none or 1\u2005month follow-up after the end of intervention. Of them, six were included in quantitative analysis. Pooled effect sizes of meta-analyses on fast and comfortable walking speed, the 6\u2005min walking test, Timed Up and Go test and maximal oxygen consumption were below the level of minimal clinical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is so far no evidence on the superiority of progressive resistance training compared with other physical training to support the use of this technique in rehabilitation of Parkinson's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration number<\/jats:title>\n                    <jats:p>PROSPERO 2014:CRD42014009844.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-008756","type":"journal-article","created":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T22:33:54Z","timestamp":1452206034000},"page":"e008756","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Progressive resistance training in Parkinson's disease: a systematic review and meta-analysis"],"prefix":"10.1136","volume":"6","author":[{"given":"Mikhail","family":"Saltychev","sequence":"first","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine, Turku University Hospital and University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esa","family":"B\u00e4rlund","sequence":"additional","affiliation":[{"name":"Satakunta University of Applied Sciences, Pori, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Paltamaa","sequence":"additional","affiliation":[{"name":"School of Health and Social Studies, JAMK University of Applied Sciences, Jyv\u00e4skyl\u00e4, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niina","family":"Katajapuu","sequence":"additional","affiliation":[{"name":"Turku University of Applied Sciences, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katri","family":"Laimi","sequence":"additional","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine, Turku University Hospital and University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,1,7]]},"reference":[{"key":"2025120521111723000_6.1.e008756.1","first-page":"645","article-title":"Restoration of muscle power by heavy-resistance exercises","volume":"27","author":"Delorme","year":"1945","journal-title":"J Bone Joint Surg Am"},{"key":"2025120521111723000_6.1.e008756.2","first-page":"263","article-title":"Technics of progressive resistance exercise","volume":"29","author":"Delorme","year":"1948","journal-title":"Arch Phys Med Rehabil"},{"key":"2025120521111723000_6.1.e008756.3","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/ptj\/85.11.1208","article-title":"Progressive resistance exercise in physical therapy: a summary of systematic reviews","volume":"85","author":"Taylor","year":"2005","journal-title":"Phys Ther"},{"key":"2025120521111723000_6.1.e008756.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2011.11.001"},{"key":"2025120521111723000_6.1.e008756.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2012.11.012"},{"key":"2025120521111723000_6.1.e008756.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1836-9553(13)70141-3"},{"key":"2025120521111723000_6.1.e008756.7","first-page":"124527","article-title":"Progressive resistance exercise and Parkinson's disease: a review of potential mechanisms","volume":"2012","author":"David","year":"2012","journal-title":"Parkinsons Dis"},{"key":"2025120521111723000_6.1.e008756.8","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21690"},{"key":"2025120521111723000_6.1.e008756.9","unstructured":"Higgins J , Green S . 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