{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:56:17Z","timestamp":1792742177017,"version":"4.5.0"},"reference-count":28,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,11,23]]},"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To explore the associations of health-related behaviours, metabolic syndrome and risk factors in adults with pre-oral cancerous (POC) lesions in rural, disadvantaged communities with a high prevalence of oral cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A cross-sectional observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Community-based health survey in the western coastal area of Yunlin County, Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>5161 adult residents participated in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>\n                      Assessed parameters included oral leukoplakia, oral submucous fibrosis, fasting blood glucose, triglycerides, high-density lipoprotein cholesterol, blood pressure and waist circumference. Statistical analyses included descriptive statistics, \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests and multivariate binary logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A high percentage of participants were found to have metabolic syndrome (40%) and POC lesions (7.3%). Participants with POC lesions tended to be male (p&lt;0.001), betel nut chewers (p&lt;0.001) and cigarette smokers (p&lt;0.001); have a low level of education (p&lt;0.001); seldom undergo dental check-ups (p&lt;0.01); irregularly participate in physical activity (p&lt;0.01) and have metabolic syndrome (p&lt;0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although male sex and disadvantaged socioeconomic status are non-modifiable factors associated with POC and metabolic syndrome in adults, several factors, notably health behaviours, are modifiable. Clinicians can reduce the incidence and consequences of POC by developing programmes for early detection, encouraging regular dental check-ups, and initiating individualised, health-promoting behaviour modification programmes for reducing risky behaviours associated with oral cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-008788","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T00:34:45Z","timestamp":1450485285000},"page":"e008788","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Metabolic syndrome and health-related behaviours associated with pre-oral cancerous lesions among adults aged 20\u201380 years in Yunlin County, Taiwan: a cross-sectional study"],"prefix":"10.1136","volume":"5","author":[{"given":"Chang-Cheng","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Plastic Surgery, Head and Neck Cancer Team, Chang Gung Memorial Hospital, Chiayi, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Shyan","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital, Yunlin, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tsung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan"},{"name":"School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Tse","family":"Tu","sequence":"additional","affiliation":[{"name":"Division of Dentistry, Cancer Center, Chang Gung Memorial Hospital, Chiayi, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Whi","family":"Jane","sequence":"additional","affiliation":[{"name":"Nursing Department, Chang Gung University of Science and Technology, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Yen","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Nursing, Chang Gung University of Science and Technology, Chiayi, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,12,18]]},"reference":[{"key":"2025102702554856000_5.12.e008788.1","unstructured":"Health Promotion Administration, Ministry of Health and Welfare. 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