{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:36:23Z","timestamp":1765827383363,"version":"build-2065373602"},"reference-count":26,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,8,21]]},"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate gender-specific and age-specific differences in the occurrence of unstable angina pectoris (UAP) caused admissions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Population-based retrospective registry study in Finland.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>All consecutive patients aged \u226530\u2005years hospitalised with a primary diagnosis of UAP in 22 hospitals with a coronary catheterisation laboratory during 5\/2000\u201310\/2009.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Primary outcome measures<\/jats:title>\n                  <jats:p>Gender-specific and age-specific differences and trends in occurrence of UAP admissions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study period included 27\u2005282 admissions caused primarily by UAP. Of these, 61.9% occurred to men and 38.1% to women with age-adjusted relative risk (RR) of 1.85 (CI 1.61 to 2.14) for the male gender (p&lt;0.0001). The standardised incidence rate of UAP during the whole study was 92.8 (CI 91.8 to 93.9)\/100\u2005000 person-years. The incidence rate increased gradually from 1.3 in the population aged 30\u201334\u2005years to 268.0\/100\u2005000 in the population aged 75\u201384\u2005years. Men had a 2.4-fold risk for UAP admission compared with women in the general population (incidence rate ratio 2.39; CI 2.24 to 2.56; p&lt;0.0001). Gender difference was present in all age groups. UAP caused 22.4% of acute coronary syndrome admissions and 4.7% of all cardiovascular admissions. UAP was more likely to be the cause of cardiovascular admission in male patients (RR=1.25; CI 1.21 to 1.30, p&lt;0.0001 compared with female patients), but there was no gender difference in acute coronary syndrome admissions. The incidence rate of UAP hospitalisations in the general population declined by an estimated 8% per study-year (p&lt;0.0001). Declining incidence was evident regardless of gender and age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Men have a 2.4-fold overall RR for UAP admission compared to women in the general population. Admissions due to UAP have a declining incidence trend across the adult Finnish population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-009025","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T20:22:58Z","timestamp":1445026978000},"page":"e009025","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Gender-specific and age-specific differences in unstable angina pectoris admissions: a population-based registry study in Finland"],"prefix":"10.1136","volume":"5","author":[{"given":"Ville","family":"Kyt\u00f6","sequence":"first","affiliation":[{"name":"Heart Center, Turku University Hospital, Turku, Finland"},{"name":"Department of Medicine, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 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