{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:06:37Z","timestamp":1790496397713,"version":"4.1.0"},"reference-count":49,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,9,30]]},"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Human leucocyte antigen (HLA) B27 and HLA-B15 are associated with spondyloarthritis (SpA). Recent Assessment of SpondyloArthritis international Society (ASAS) criteria emphasise a distinction between SpA with axial and peripheral patterns. We analysed whether HLA-A, HLA-B and HLA-DRB1 alleles could associate with these patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 100 healthy individuals and 178 patients with SpA according to European Spondyloarthropathy Study Group (ESSG) criteria. Patients were then classified according to ASAS criteria, the axial spondyloarthritis pattern (axSpA) being defined by ascertained sacroiliitis and the peripheral pattern (pSpA) by enthesitis and\/or arthritis in extremities. A combined ax\/p pattern was also considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Only HLA-B27 and HLA-B15 alleles were associated with SpA. ASAS criteria for axSpA were met in 152 patients (12 with isolated axSpA and 140 with a combined ax\/p patterns). When the ASAS peripheral criteria were applied, 161 patients met these criteria (13 with isolated pSpA and 148 with a combined ax\/p pattern). HLA-B27 was found in 83% of patients with axSpA and 43% of ax\/pSpA patients according to axASAS. HLA-B27 occurred in 7% controls but not in any patient with isolated pSpA. HLA-B15 was encountered in 31% of patients with isolated pSpA and 20% of ax\/pSpA patients according to pASAS criteria. Moreover, 2 healthy controls, but none of our patients with isolated axSpA were positive for HLA-B15.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data suggest that the presence of HLA-B15 favours the development of isolated\/combined peripheral rather than isolated axSpA, while HLA-B27 promotes an isolated\/combined axial disease and excludes a peripheral pattern. HLA-B15 should be considered in addition to HLA-B27 when diagnosing patients with SpA according to ASAS criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-009092","type":"journal-article","created":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T20:58:01Z","timestamp":1447275481000},"page":"e009092","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns"],"prefix":"10.1136","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1074-644X","authenticated-orcid":false,"given":"John","family":"Londono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis R","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D","family":"Reveille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Vargas-Alarcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A","family":"Jaramillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Valle-O\u00f1ate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mabel","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,11,11]]},"reference":[{"key":"2024051514403906000_5.11.e009092.1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-12-200206180-00011"},{"key":"2024051514403906000_5.11.e009092.2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341003"},{"key":"2024051514403906000_5.11.e009092.3","first-page":"605","article-title":"Ankylosing spondylitis: how should the disease be assessed? 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The epidemiological diagnosis of ankylosing spondylitis. In: Bennett PH , Wood PHN , eds. Population studies of the rheumatic diseases. Amsterdam: Excerpta Medica, 1968:453\u20138."},{"key":"2024051514403906000_5.11.e009092.33","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.110767"},{"key":"2024051514403906000_5.11.e009092.34","first-page":"2140","article-title":"Genuine ankylosing spondylitis in children: a case-control study of patients with early definite disease according to adult onset criteria","volume":"23","author":"Burgos-Vargas","year":"1996","journal-title":"J Rheumatol"},{"key":"2024051514403906000_5.11.e009092.35","doi-asserted-by":"publisher","DOI":"10.1002\/art.20233"},{"key":"2024051514403906000_5.11.e009092.36","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1411-9"},{"key":"2024051514403906000_5.11.e009092.37","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.140574"},{"key":"2024051514403906000_5.11.e009092.38","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200107000-00004"},{"key":"2024051514403906000_5.11.e009092.39","first-page":"A270","article-title":"Outcome of patients with undifferentiated seronegative spondyloarthropathy","volume":"40","author":"Valle","year":"1997","journal-title":"Arthritis Rheum"},{"key":"2024051514403906000_5.11.e009092.40","first-page":"195","article-title":"Caracterizaci\u00f3n de las espondiloartropat\u00edas y determinaci\u00f3n de factores de mal pron\u00f3stico en una poblaci\u00f3n de pacientes colombianos","volume":"12","author":"Londono","year":"2005","journal-title":"Rev Colomb Reumatol"},{"key":"2024051514403906000_5.11.e009092.41","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090625"},{"key":"2024051514403906000_5.11.e009092.42","first-page":"2266","article-title":"The evolution of spondyloarthropathies in relation to gut histology. 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