{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:31:25Z","timestamp":1791502285352,"version":"4.3.4"},"reference-count":27,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,12,14]]},"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of varenicline for smoking cessation in Chinese smokers in a real world cessation clinic practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A prospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Beijing, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A total of 924 smokers (883 men and 41 women) who attended a smoking cessation clinic of a large general hospital were assessed with data from structured questionnaires at baseline and follow-up at 1, 3 and 6\u2005months. Trained physician counsellors provided free individual counselling for all subjects and follow-up interviews with brief counselling. 332 subjects additionally prescribed varenicline according to their own choice were compared with those without varenicline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Primary outcomes were self-reported 7-day point prevalence abstinence rate and 3-month continuous abstinence rate at 6-month follow-up. Secondary outcomes were 7-day point prevalence abstinence rates at 1 and 3-month follow-up, and 1-month continuous abstinence rate at 3-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>By intention-to-treat, the 7-day point prevalence abstinence rate with varenicline and counselling at 6\u2005months was significantly higher than counselling only (37.0% vs 23.1%; OR, 1.75; 95% CI 1.46 to 2.62; p=0.001). The 3-month continuous abstinence rate at 6\u2005months was higher with varenicline (33.1% vs 18.4%; OR, 2.04; 95% CI 1.61 to 2.99; p&lt;0.001). Varenicline also showed better secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Varenicline prescription in the smoking cessation clinic appeared to be effective with doubling of quit rates in Chinese smokers in a real world cessation clinic practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>NCT01935505; Results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-009381","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T22:29:42Z","timestamp":1452119382000},"page":"e009381","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of varenicline and counselling for smoking cessation in an observational cohort study in China"],"prefix":"10.1136","volume":"6","author":[{"given":"Bin","family":"Jiang","sequence":"first","affiliation":[{"name":"Nanlou Faculty of Clinical Medicine, Department of Traditional Chinese Medicine and Acupuncture, Chinese People's Liberation Army General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Institute of Geriatrics, Beijing key laboratory of Aging and Geriatrics, Chinese People's Liberation Army General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zuo","sequence":"additional","affiliation":[{"name":"Nanlou Faculty of Clinical Medicine, Department of Traditional Chinese Medicine and Acupuncture, Chinese People's Liberation Army General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Institute of Geriatrics, Beijing key laboratory of Aging and Geriatrics, Chinese People's Liberation Army General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Nanlou Faculty of Clinical Medicine, Department of Respiration, Chinese People's Liberation Army General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanlou Faculty of Clinical Medicine, Department of Rehabilitation, Chinese People's Liberation Army General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Xi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Nanlou Faculty of Clinical Medicine, Department of Respiration, Chinese People's Liberation Army General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K K","family":"Cheng","sequence":"additional","affiliation":[{"name":"Public Health, Epidemiology and Biostatistics, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia S C","family":"Chan","sequence":"additional","affiliation":[{"name":"School of Nursing, School of Public Health, The University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai Hing","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, School of Public Health and The University of Hong Kong, Hong Kong, 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