{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:30:28Z","timestamp":1781616628828,"version":"3.54.5"},"reference-count":11,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,12,18]]},"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the efficacy of Honevo, a topical 90% medical-grade kanuka honey, and 10% glycerine (honey product) as a treatment for facial acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomised controlled trial with single blind assessment of primary outcome variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Outpatient primary care from 3 New Zealand localities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Of 136 participants aged between 16 and 40\u2005years with a diagnosis of acne and baseline Investigator's Global Assessment (IGA) for acne score of \u22652.68, participants were randomised to each treatment arm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>All participants applied Protex, a triclocarban-based antibacterial soap twice daily for 12\u2005weeks. Participants randomised to the honey product treatment arm applied this directly after washing off the antibacterial soap, twice daily for 12\u2005weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome measures<\/jats:title><jats:p>The primary outcome was \u22652 point decrease in IGA score from baseline at 12\u2005weeks. Secondary outcomes included mean lesion counts and changes in subject-rated acne improvement and severity at weeks 4 and 12, and withdrawals for worsening acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>4\/53 (7.6%) participants in the honey product group and 1\/53 (1.9%) of participants in the control group had a \u2265 2 improvement in IGA score at week 12, compared with baseline, OR (95% CI) for improvement 4.2 (0.5 to 39.3), p=0.17. There were 15 and 14 participants who withdrew from the honey product group and control group, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This randomised controlled trial did not find evidence that addition of medical-grade kanuka honey in combination with 10% glycerine to standard antibacterial soap treatment is more effective than the use of antibacterial soap alone in the treatment of acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p>ACTRN12614000003673; Results.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2015-009448","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T02:44:18Z","timestamp":1454381058000},"page":"e009448","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Randomised controlled trial of topical kanuka honey for the treatment of acne"],"prefix":"10.1136","volume":"6","author":[{"given":"Alex","family":"Semprini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5327-3027","authenticated-orcid":false,"given":"Irene","family":"Braithwaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Corin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davitt","family":"Sheahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Tofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Helm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barney","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Fingleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Weatherall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Beasley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,2,1]]},"reference":[{"key":"2024051514512151000_6.2.e009448.1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12149"},{"key":"2024051514512151000_6.2.e009448.2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6171.1109"},{"key":"2024051514512151000_6.2.e009448.3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1517\/14656566.2014.860965","article-title":"Current and future evidence-based acne treatment: a review","volume":"15","author":"Sandoval","year":"2014","journal-title":"Expert Opin Pharmacother"},{"key":"2024051514512151000_6.2.e009448.4","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1111\/jdv.12989","article-title":"Topical acne treatments in Europe and the issue of antimicrobial resistance","volume":"29","author":"Leccia","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2024051514512151000_6.2.e009448.5","unstructured":"Hippocrates. 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Guidance for Industry Acne Vulgaris: Developing Drugs for Treatment . 2005. http:\/\/www.fda.gov\/downloads\/drugs\/guidancecomplianceregulatoryinformation\/guidances\/ucm071292.pdf"},{"key":"2024051514512151000_6.2.e009448.10","doi-asserted-by":"publisher","DOI":"10.3109\/09546639809160698"},{"key":"2024051514512151000_6.2.e009448.11","first-page":"27","article-title":"The role of inflammation in the pathology of acne","volume":"6","author":"Tanghetti","year":"2013","journal-title":"J Clin Aesthet Dermatol"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2015-009448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T22:03:13Z","timestamp":1715810593000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2015-009448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,1]]},"published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1136\/bmjopen-2015-009448"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2015-009448","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}