{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:34:53Z","timestamp":1790634893648,"version":"4.1.0"},"reference-count":40,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,11,25]]},"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Inflammation is a well-established risk factor for the development of coronary artery disease (CAD) and acute coronary syndrome (ACS). However, less is known about its influence on the outcome of ACS. The aim of this study was to determine if blood biomarkers of inflammation were associated specifically with acute myocardial infarction (MI) or unstable angina (UA) in patients with ACS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Patients admitted to the coronary care unit, via the emergency room, at a central county hospital over a 4-year period (1992\u20131996).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>In a substudy of Carlscrona Heart Attack Prognosis Study (CHAPS) of 5292 patients admitted to the coronary care unit, we identified 908 patients aged 30\u201374\u2005years, who at discharge had received the diagnosis of either MI (527) or UA (381).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>MI or UA, based on the diagnosis set at discharge from hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>When adjusted for smoking, age, sex and duration of chest pain, concentrations of plasma biomarkers of inflammation (high-sensitivity C reactive protein&gt;2\u2005mg\/L (OR=1.40 (1.00 to 1.96) and fibrinogen (p for trend=0.035)) analysed at admission were found to be associated with MI over UA, in an event of ACS. A strong significant association with MI over UA was found for blood cell markers of inflammation, that is, counts of neutrophils (p for trend&lt;0.001), monocytes (p for trend&lt;0.001) and thrombocytes (p for trend=0.021), while lymphocyte count showed no association. Interestingly, eosinophil count (p for trend=0.003) was found to be significantly lower in patients with MI compared to those with UA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results show that, in patients with ACS, the blood cell profile and degree of inflammation at admission was associated with the outcome. Furthermore, our data suggest that a pre-existing low-grade inflammation may dispose towards MI over UA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-009968","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T13:57:34Z","timestamp":1452693454000},"page":"e009968","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Influence of pre-existing inflammation on the outcome of acute coronary syndrome: a cross-sectional study"],"prefix":"10.1136","volume":"6","author":[{"given":"Jacob","family":"Odeberg","sequence":"first","affiliation":[{"name":"Department of Proteomics, KTH, Science for Life Laboratory Stockholm, Solna, Sweden"},{"name":"Centre for Hematology, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Freitag","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences in Malm\u00f6, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Forssell","sequence":"additional","affiliation":[{"name":"Blekinge Centre of Competence, Karlskrona, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivar","family":"Vaara","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Blekinge County Hospital, Karlskrona, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Louise","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Blekinge County Hospital, Karlskrona, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Odeberg","sequence":"additional","affiliation":[{"name":"Blekinge Centre of Competence, Karlskrona, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Halling","sequence":"additional","affiliation":[{"name":"Research Unit of General Practice, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"R\u00e5stam","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences in Malm\u00f6, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Lindblad","sequence":"additional","affiliation":[{"name":"Department of Community Medicine\/Primary Health Care, University of Gothenburg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,1,12]]},"reference":[{"key":"2025121600212742000_6.1.e009968.1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.097360"},{"key":"2025121600212742000_6.1.e009968.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1216063"},{"key":"2025121600212742000_6.1.e009968.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.064"},{"key":"2025121600212742000_6.1.e009968.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012295"},{"key":"2025121600212742000_6.1.e009968.5","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200701000-00011"},{"key":"2025121600212742000_6.1.e009968.6","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-005077"},{"key":"2025121600212742000_6.1.e009968.7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000100688.17280.E6"},{"key":"2025121600212742000_6.1.e009968.8","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs184"},{"key":"2025121600212742000_6.1.e009968.9","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/j.1538-7836.2006.01835.x","article-title":"Severity of acute coronary syndrome is predicted by interactions between fibrinogen concentrations and polymorphisms in the GPIIIa and FXIII genes","volume":"4","author":"Odeberg","year":"2006","journal-title":"J Thromb Haemost"},{"key":"2025121600212742000_6.1.e009968.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.10.018"},{"key":"2025121600212742000_6.1.e009968.11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/13506129.2011.654294","article-title":"Acute-phase serum amyloid A: perspectives on its physiological and pathological roles","volume":"19","author":"Kisilevsky","year":"2012","journal-title":"Amyloid"},{"key":"2025121600212742000_6.1.e009968.12","doi-asserted-by":"crossref","unstructured":"Th\u00e9roux P . 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