{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:36:31Z","timestamp":1792686991362,"version":"4.5.0"},"reference-count":42,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,11,18]]},"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess the role of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection and interleukin 6 polymorphism -174 (rs1800795) in dyslipidemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Case\u2013control study comparing serum lipids between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      positive and negative patients and controlling for IL-6 -174 polymorphism, age, sex and smoking.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>3 hospitals performing outpatient endoscopies in the city of Oulu, Finland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      199 adult patients with dyspepsia symptoms fulfilling Rome criteria originating from ethnically Finnish population. Patients with an immunosuppressive disorder or malignant disease, treated\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection, immunosuppressive or anticoagulant medication, previous gastric surgery or ongoing antibiotic treatment were excluded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary outcome measures<\/jats:title>\n                    <jats:p>\n                      Association of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection and serum lipid concentrations in the whole group or in genotype-based subgroups. The associations between peptic ulcer, gastric mucosal inflammation and serum lipid concentrations were assessed as secondary outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median high-density lipoprotein (HDL) serum concentration was significantly lower in the\n                      <jats:italic>H. pylori<\/jats:italic>\n                      positive group (0.81\u2005mmol\/L) than in the negative group (0.95\u2005mmol\/L; p&lt;0.001). In the genotype subgroup analyses, a similar association between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection and HDL serum levels was seen within the IL-6 -174 CC genotype group (HDL 0.72 vs 1.06\u2005mmol\/L, respectively; p&lt;0.001), but no significant associations were seen in the GC or GG genotype groups. Additionally, patients with peptic ulcer demonstrated lower HDL levels (0.75\u2005mmol\/L) than\n                      <jats:italic>H. pylori<\/jats:italic>\n                      positive patients without ulcer (0.86\u2005mmol\/L; p=0.010).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection associated significantly with low serum levels of HDL in the IL-6 -174 CC genotype patients but not in the other genotypes. This suggests that the association between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection and serum HDL could be transmitted through IL-6. We suggest that the role of IL-6 genotype should also be studied in relation to other associations between gastrointestinal microbiome and cardiovascular risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-009987","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T21:03:16Z","timestamp":1453150996000},"page":"e009987","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Role of\n                    <i>Helicobacter pylori<\/i>\n                    and interleukin 6 -174 gene polymorphism in dyslipidemia: a case\u2013control study"],"prefix":"10.1136","volume":"6","author":[{"given":"Vesa-Matti","family":"Pohjanen","sequence":"first","affiliation":[{"name":"Department of Pathology, Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, 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