{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:16:50Z","timestamp":1774963010492,"version":"3.50.1"},"reference-count":39,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,10,5]]},"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The Rehabilitation EnAblement in CHronic Heart Failure (REACH-HF) trial is part of a research programme designed to develop and evaluate a health professional facilitated, home-based, self-help rehabilitation intervention to improve self-care and health-related quality of life in people with heart failure and their caregivers. The trial will assess the clinical effectiveness and cost-effectiveness of the REACH-HF intervention in patients with systolic heart failure and impact on the outcomes of their caregivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>A parallel two group randomised controlled trial with 1:1 individual allocation to the REACH-HF intervention plus usual care (intervention group) or usual care alone (control group) in 216 patients with systolic heart failure (ejection fraction &lt;45%) and their caregivers. The intervention comprises a self-help manual delivered by specially trained facilitators over a 12-week period. The primary outcome measure is patients\u2019 disease-specific health-related quality of life measured using the Minnesota Living with Heart Failure questionnaire at 12\u2005months\u2019 follow-up. Secondary outcomes include survival and heart failure related hospitalisation, blood biomarkers, psychological well-being, exercise capacity, physical activity, other measures of quality of life, patient safety and the quality of life, psychological well-being and perceived burden of caregivers at 4, 6 and 12\u2005months\u2019 follow-up. A process evaluation will assess fidelity of intervention delivery and explore potential mediators and moderators of changes in health-related quality of life in intervention and control group patients. Qualitative studies will describe patient and caregiver experiences of the intervention. An economic evaluation will estimate the cost-effectiveness of the REACH-HF intervention plus usual care versus usual care alone in patients with systolic heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study is approved by the North West\u2014Lancaster Research Ethics Committee (ref 14\/NW\/1351). Findings will be disseminated via journals and presentations to publicise the research to clinicians, commissioners and service users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ISRCTN86234930; Pre-results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-009994","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T21:16:55Z","timestamp":1450905415000},"page":"e009994","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Clinical effectiveness and cost-effectiveness of the Rehabilitation Enablement in Chronic Heart Failure (REACH-HF) facilitated self-care rehabilitation intervention in heart failure patients and caregivers: rationale and protocol for a multicentre randomised controlled trial"],"prefix":"10.1136","volume":"5","author":[{"given":"R S","family":"Taylor","sequence":"first","affiliation":[{"name":"Institute of Health Research, University of Exeter Medical School, Exeter, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Hayward","sequence":"additional","affiliation":[{"name":"Peninsula Clinical Trials Unit, Plymouth University, Plymouth, Devon, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Eyre","sequence":"additional","affiliation":[{"name":"Peninsula Clinical Trials Unit, Plymouth University, Plymouth, Devon, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Austin","sequence":"additional","affiliation":[{"name":"Heart Failure Services and Cardiac Rehabilitation, Aneurin Bevan University Health Board, Nevill Hall Hospital, Abergavenny, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Davies","sequence":"additional","affiliation":[{"name":"Cardiology Department, Sandwell & West Birmingham Hospitals NHS Trust, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Doherty","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of York, York, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Jolly","sequence":"additional","affiliation":[{"name":"Institute for Applied Health Research, University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Wingham","sequence":"additional","affiliation":[{"name":"Institute of Health Research, University of Exeter Medical School, Exeter, UK"},{"name":"Department of Research, Development & Innovation, Royal Cornwall Hospitals NHS Trust, Truro, 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Health Research, University of Exeter Medical School, Exeter, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C J","family":"Greaves","sequence":"additional","affiliation":[{"name":"Institute of Health Research, University of Exeter Medical School, Exeter, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Singh","sequence":"additional","affiliation":[{"name":"Centre for Exercise and Rehabilitation Science, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Buckingham","sequence":"additional","affiliation":[{"name":"Department of Research, Development & Innovation, Royal Cornwall Hospitals NHS Trust, Truro, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Paul","sequence":"additional","affiliation":[{"name":"REACH-HF Patient and Public Involvement Group, c\/o Research, Development & Innovation, Royal 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