{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T18:13:13Z","timestamp":1765735993812,"version":"3.48.0"},"reference-count":23,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2016,2,23]]},"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Adenotonsillar hypertrophy is the most important anatomical factor associated with obstructive sleep apnoea syndrome in children. The American Academy of Pediatrics recommends adenotonsillectomy as the first line of treatment. AT can reduce the apnoea hypopnoea index; however, its effect on long-term outcomes remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>We will conduct an electronic search for randomised controlled trials in MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL) and EMBASE. We will also identify literature by reviewing the references included in the selected studies and relevant reviews, screening through important scientific conferences, and searching for ongoing trials in the WHO International Clinical Trials Registry Platform. Two researchers will independently undertake selection of studies, data extraction and assessment of the risk of bias of included studies. We will estimate pooled risk ratios for dichotomous data, and mean difference or standardised mean difference for continuous outcomes. A random-effects model will be used for meta-analyses. Data synthesis and other analyses will be conducted using RevMan V.5.3 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>No ethics approval is considered necessary. The results of this study will be disseminated via peer-reviewed publications and social networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>CRD42015022102.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-010030","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T22:08:53Z","timestamp":1472854133000},"page":"e010030","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Long-term effects of adenotonsillectomy in children with obstructive sleep apnoea: protocol for a systematic review"],"prefix":"10.1136","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-0488","authenticated-orcid":false,"given":"Felipe","family":"Damiani","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Pontificia Universidad Cat\u00f3lica de Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2435-0710","authenticated-orcid":false,"given":"Gabriel","family":"Rada","sequence":"additional","affiliation":[{"name":"Evidence-Based Healthcare Program, Pontificia Universidad Cat\u00f3lica de Chile"},{"name":"Department of Internal Medicine, Pontificia Universidad Cat\u00f3lica de Chile"},{"name":"Epistemonikos foundation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Crist\u00f3bal","family":"Gana","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Gastroenterology and Nutrition, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo E","family":"Brockmann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Pulmonology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile"},{"name":"Faculty of Medicine, Sleep Medicine Center, Pontificia Universidad Cat\u00f3lica de Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gigliola","family":"Alberti","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Gastroenterology and Nutrition, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,9,2]]},"reference":[{"key":"2025121410111416000_6.9.e010030.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2012.08.004"},{"key":"2025121410111416000_6.9.e010030.2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-1224"},{"key":"2025121410111416000_6.9.e010030.3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.4.e69"},{"key":"2025121410111416000_6.9.e010030.4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1672"},{"key":"2025121410111416000_6.9.e010030.5","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.152"},{"key":"2025121410111416000_6.9.e010030.6","first-page":"109","article-title":"Obstructive sleep apnea in children: a critical update","volume":"5","author":"Tan","year":"2013","journal-title":"Nat Sci Sleep"},{"key":"2025121410111416000_6.9.e010030.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.11.003"},{"key":"2025121410111416000_6.9.e010030.8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2568"},{"key":"2025121410111416000_6.9.e010030.9","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.101089"},{"key":"2025121410111416000_6.9.e010030.10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/jamapediatrics.2015.2016","article-title":"Toward adenotonsillectomy in children","volume":"169","author":"Ingram","year":"2015","journal-title":"JAMA Pediatr"},{"key":"2025121410111416000_6.9.e010030.11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1283"},{"key":"2025121410111416000_6.9.e010030.12","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.93"},{"key":"2025121410111416000_6.9.e010030.13","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23860"},{"key":"2025121410111416000_6.9.e010030.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(03)00727-7"},{"key":"2025121410111416000_6.9.e010030.15","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318123ee56"},{"key":"2025121410111416000_6.9.e010030.16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215881"},{"key":"2025121410111416000_6.9.e010030.17","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.2.190"},{"key":"2025121410111416000_6.9.e010030.18","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200310000-00003"},{"key":"2025121410111416000_6.9.e010030.19","doi-asserted-by":"crossref","unstructured":"Lim J , McKean MC . 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