{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:47:47Z","timestamp":1780678067687,"version":"3.54.1"},"reference-count":40,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,11,17]]},"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study aimed to examine the association between apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) polymorphism and metabolic syndrome (MetS) among Uyghur ethnic men in Xinjiang, China.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      A total of 482 patients with MetS and 510 healthy sex-matched and age-matched controls were recruited from the Xinjiang Uyghur Autonomous Region of China. The participants were subjected to routine physical and blood biochemical tests, and\n                      <jats:italic>APOE<\/jats:italic>\n                      genotyping was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>APOE \u03b53\/3<\/jats:italic>\n                      was the predominant type, with a frequency of 71.8%, while\n                      <jats:italic>\u03b52\/2<\/jats:italic>\n                      was less common than\n                      <jats:italic>\u03b54\/4<\/jats:italic>\n                      in Uyghur males. The frequencies of the\n                      <jats:italic>APOE2, E3<\/jats:italic>\n                      and\n                      <jats:italic>E4<\/jats:italic>\n                      alleles in Uyghur males were 8.5%, 80.0% and 11.5%, respectively. However, the distribution of\n                      <jats:italic>APOE<\/jats:italic>\n                      genotypes was significantly different between the MetS and control groups (p&lt;0.001). In the MetS group, the frequencies of the\n                      <jats:italic>\u03b5<\/jats:italic>\n                      2 and\n                      <jats:italic>\u03b5<\/jats:italic>\n                      4 alleles and the frequencies of the\n                      <jats:italic>\u03b52\/2<\/jats:italic>\n                      ,\n                      <jats:italic>\u03b52\/3 and \u03b52\/4<\/jats:italic>\n                      genotypes were significantly lower than those of the control group. Those individuals without the\n                      <jats:italic>\u03b5<\/jats:italic>\n                      2 and\n                      <jats:italic>\u03b5<\/jats:italic>\n                      4 alleles had higher MetS prevalence than the other gene carriers, and the ORs of these individuals developing MetS were 1.5 and 1.27 compared to the gene carriers. Triglyceride, serum total cholesterol and low-density lipoprotein cholesterol levels were lower and serum high-density lipoprotein was higher in the\n                      <jats:italic>\u03b5<\/jats:italic>\n                      2 carriers than the\n                      <jats:italic>\u03b5<\/jats:italic>\n                      3 carriers, and the prevalence of MetS, central obesity, high blood pressure, hypercholesterolaemia and hypertriglyceridaemia was lower in the\n                      <jats:italic>APOE<\/jats:italic>\n                      2 group than in the\n                      <jats:italic>APOE<\/jats:italic>\n                      4 group. The risks of these individuals with\n                      <jats:italic>\u03b5<\/jats:italic>\n                      4 allele carriers getting these changes were 1.327, 1.780, 1.888, 1.428 and 2.571 times greater than those of \u03b52 allele carriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>APOE<\/jats:italic>\n                      4 is associated with many individual components of MetS, whereas\n                      <jats:italic>APOE<\/jats:italic>\n                      2 was associated with a reduced risk of MetS at the univariate level in Uyghur ethnic men.\n                    <\/jats:p>\n                  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