{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:03:42Z","timestamp":1765008222417,"version":"3.46.0"},"reference-count":31,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2015,12,23]]},"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Atrial fibrillation is the most common arrhythmia. Its management aims to reduce symptoms and to prevent complications through rate and rhythm control, management of concomitant cardiac diseases and prevention of related complications, mainly stroke. The main objective of Effectiveness, Safety and Costs in Atrial Fibrillation (ESC-FA) study is to analyse the drugs used for the management of the disease in real-use conditions, particularly the antithrombotic agents for stroke prevention. The aim of this work is to present the study protocol of phase I of the ESC-FA study and the baseline characteristics of newly diagnosed patients with atrial fibrillation in Catalonia, Spain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The data source is System for the Improvement of Research in Primary Care (SIDIAP) database. The population included are all patients with non-valvular atrial fibrillation diagnosis registered in the electronic health records during 2007\u20132012.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings to date<\/jats:title>\n                    <jats:p>A total of 22\u2005585 patients with non-valvular atrial fibrillation were included in the baseline description. Their mean age was 72.8\u2005years and 51.6% were men. The most commonly prescribed antithrombotics were vitamin K antagonists (40.1% of patients) and platelet aggregation inhibitors (32.9%); 25.3% had not been prescribed antithrombotic treatment. Age, gender, comorbidities and co-medication at baseline were similar to those reported for previous studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future plans<\/jats:title>\n                    <jats:p>The next phase in the ESC-FA study will involve assessing the effectiveness and safety of antithrombotic treatments, analysing stroke events and bleeding episodes\u2019 rates in our patients (rest of phase I), describing the current management of the disease and its costs in our setting, and assessing how the introduction of new oral anticoagulants changes the stroke prevention in non-valvular atrial fibrillation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-010144","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T22:53:56Z","timestamp":1454021636000},"page":"e010144","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness, safety and costs of thromboembolic prevention in patients with non-valvular atrial fibrillation: phase I ESC-FA protocol study and baseline characteristics of a cohort from a primary care electronic database"],"prefix":"10.1136","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3750-9233","authenticated-orcid":false,"given":"Maria","family":"Giner-Soriano","sequence":"first","affiliation":[{"name":"Institut Universitari d'Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Vedia Urgell","sequence":"additional","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Spain"},{"name":"Unitat de farm\u00e0cia, Servei d'Atenci\u00f3 Prim\u00e0ria Barcelon\u00e8s Nord i Maresme, Institut Catal\u00e0 de la Salut, Badalona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Roso-Llorach","sequence":"additional","affiliation":[{"name":"Institut Universitari d'Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Morros","sequence":"additional","affiliation":[{"name":"Institut Universitari d'Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolors","family":"Capell\u00e0","sequence":"additional","affiliation":[{"name":"Translab Research Group, Unitat de Farmacologia Cl\u00ednica, Departament de Ci\u00e8ncies M\u00e8diques, Facultat de Medicina, UdG, Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Castells","sequence":"additional","affiliation":[{"name":"Translab Research Group, Unitat de Farmacologia Cl\u00ednica, Departament de Ci\u00e8ncies M\u00e8diques, Facultat de Medicina, UdG, Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Ferreira-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Unidad de Epidemiolog\u00eda del Servicio de Cardiolog\u00eda, Hospital Vall d'Hebron y CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia","family":"Troncoso Mari\u00f1o","sequence":"additional","affiliation":[{"name":"Unitat de Coordinaci\u00f3 i Estrat\u00e8gia del Medicament, Institut Catal\u00e0 de la Salut, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Di\u00f2gene","sequence":"additional","affiliation":[{"name":"Servei de Farmacologia, Hospital Vall d'Hebron, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep M\u00aa","family":"Elorza","sequence":"additional","affiliation":[{"name":"System for the Improvement of Research in Primary Care (SIDIAP), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Casajuana","sequence":"additional","affiliation":[{"name":"Institut Universitari d'Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonaventura","family":"Bol\u00edbar","sequence":"additional","affiliation":[{"name":"Institut Universitari d'Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepci\u00f3","family":"Violan","sequence":"additional","affiliation":[{"name":"Institut Universitari d'Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,1,28]]},"reference":[{"key":"2025120523590944000_6.1.e010144.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61514-6"},{"key":"2025120523590944000_6.1.e010144.2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs253"},{"key":"2025120523590944000_6.1.e010144.3","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.medcli.2011.05.023","article-title":"Prevalencia de la fibrilaci\u00f3n auricular y factores relacionados en pacientes ancianos hospitalizados: estudio ESFINGE","volume":"138","author":"L\u00f3pez-Soto","year":"2012","journal-title":"Med Clin (Barc)"},{"key":"2025120523590944000_6.1.e010144.4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq278"},{"key":"2025120523590944000_6.1.e010144.5","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2011.584063"},{"key":"2025120523590944000_6.1.e010144.6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-12-200706190-00007"},{"key":"2025120523590944000_6.1.e010144.7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.22.2864"},{"key":"2025120523590944000_6.1.e010144.8","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-02-0061"},{"key":"2025120523590944000_6.1.e010144.9","unstructured":"NICE. NI for H& CE. Atrial fibrillation: the management of atrial fibrillation. 2014."},{"key":"2025120523590944000_6.1.e010144.10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0134"},{"key":"2025120523590944000_6.1.e010144.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.09.024"},{"key":"2025120523590944000_6.1.e010144.12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.055079"},{"key":"2025120523590944000_6.1.e010144.13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d124"},{"key":"2025120523590944000_6.1.e010144.14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.medcli.2012.05.046","article-title":"Anticoagulation in polypathological patients with atrial fibrillation","volume":"140","author":"D\u00edez-Manglano","year":"2012","journal-title":"Med Clin (Barc)"},{"key":"2025120523590944000_6.1.e010144.15","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.recesp.2011.03.014","article-title":"Impacto de los nuevos criterios para el tratamiento anticoagulante de la fibrilaci\u00f3n auricular","volume":"64","author":"Rodr\u00edguez-Ma\u00f1ero","year":"2011","journal-title":"Rev Esp Cardiol"},{"key":"2025120523590944000_6.1.e010144.16","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0300-8932(10)70206-2","article-title":"Prevalencia de fibrilaci\u00f3n auricular y uso de f\u00e1rmacos antitromb\u00f3ticos en el paciente hipertenso \u2265 65 a\u00f1os. El registro FAPRES","volume":"63","author":"Morillas","year":"2010","journal-title":"Rev Esp Cardiol"},{"key":"2025120523590944000_6.1.e010144.17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0025-7753(02)72375-0","article-title":"Empleo de f\u00e1rmacos antitromb\u00f3ticos en pacientes hipertensos con fibrilaci\u00f3n auricular cr\u00f3nica. Estudio CARDIOTENS 99","volume":"118","author":"Bertomeu-Mart\u00ednez","year":"2002","journal-title":"Med Clin (Barc)"},{"key":"2025120523590944000_6.1.e010144.18","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.medcli.2012.01.020","article-title":"SIDIAP database: electronic clinical records in primary care as a source of information for epidemiologic research","volume":"138","author":"Bol\u00edbar","year":"2012","journal-title":"Med Clin (Barc)"},{"key":"2025120523590944000_6.1.e010144.19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.recesp.2011.07.017","article-title":"Validity for use in research on vascular diseases of the SIDIAP (Information System for the Development of Research in Primary Care): the EMMA study","volume":"65","author":"Ramos","year":"2012","journal-title":"Rev Esp Cardiol"},{"key":"2025120523590944000_6.1.e010144.20","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1679"},{"key":"2025120523590944000_6.1.e010144.21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1471-2474-13-79","article-title":"\u201cBurden of osteoporotic fractures in primary health care in Catalonia (Spain): a population-based study\u201d","volume":"13","author":"Pag\u00e8s-Castell\u00e0","year":"2012","journal-title":"BMC Musculoskelet Disord"},{"key":"2025120523590944000_6.1.e010144.22","first-page":"135","article-title":"Construction and validation of a scoring system for the selection of high-quality data in a Spanish population primary care database (SIDIAP)","volume":"19","author":"Garc\u00eda-Gil Mdel","year":"2011","journal-title":"Inform Prim Care"},{"key":"2025120523590944000_6.1.e010144.23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1157\/13123961","article-title":"Construcci\u00f3n de un \u00edndice de privaci\u00f3n a partir de datos censales en grandes ciudades espa\u00f1olas (Proyecto MEDEA)","volume":"22","author":"Dom\u00ednguez-Berj\u00f3n","year":"2008","journal-title":"Gac Sanit"},{"key":"2025120523590944000_6.1.e010144.24","doi-asserted-by":"crossref","first-page":"297","DOI":"10.7326\/0003-4819-151-5-200909010-00003","article-title":"The net clinical benefit of warfarin anticoagulation in atrial fibrillation","volume":"151","author":"Singer","year":"2010","journal-title":"Ann Intern Med"},{"key":"2025120523590944000_6.1.e010144.25","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"2025120523590944000_6.1.e010144.26","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq433"},{"key":"2025120523590944000_6.1.e010144.27","doi-asserted-by":"crossref","first-page":"pii: e002758","DOI":"10.1136\/bmjopen-2013-002758","article-title":"Dabigatran use in Danish atrial fibrillation patients in 2011: a nationwide study","volume":"3","author":"S\u00f8rensen","year":"2013","journal-title":"BMJ Open"},{"key":"2025120523590944000_6.1.e010144.28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.recesp.2011.08.008","article-title":"Patients with atrial fibrillation in a primary care setting: Val-FAAP study","volume":"65","author":"Barrios","year":"2012","journal-title":"Rev Esp Cardiol"},{"key":"2025120523590944000_6.1.e010144.29","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut263"},{"key":"2025120523590944000_6.1.e010144.30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063479"},{"key":"2025120523590944000_6.1.e010144.31","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302843"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2015-010144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:59:19Z","timestamp":1765007959000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2015-010144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,28]]},"published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1136\/bmjopen-2015-010144"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2015-010144","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}