{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:11:19Z","timestamp":1789103479206,"version":"build-2803163510"},"reference-count":27,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2016,2,22]]},"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate the rate of recording of premenstrual syndrome diagnoses in UK primary care and describe pharmacological treatments initiated following a premenstrual syndrome (PMS) diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Retrospective cohort study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>UK primary care.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Women registered with a practice contributing to The Health Improvement Network primary care database between 1995 and 2013.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Primary and secondary outcome measures<\/jats:title>\n                  <jats:p>The primary outcome was the rate of first premenstrual syndrome records per 1000 person years, stratified by calendar year and age. The secondary outcome was the proportions of women with a premenstrual syndrome record prescribed a selective serotonin reuptake inhibitor, progestogen, oestrogen, combined oral contraceptive, progestin only contraceptive, gonadotrophin-releasing hormone, danazol and vitamin B<jats:sub>6<\/jats:sub>.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The rate of recording of premenstrual syndrome diagnoses decreased over calendar time from 8.43 in 1995 to 1.72 in 2013. Of the 38\u2005614 women without treatment in the 6\u2005months prior to diagnosis, 54% received a potentially premenstrual syndrome-related prescription on the day of their first PMS record while 77% received a prescription in the 24\u2005months after. Between 1995 and 1999, the majority of women were prescribed progestogens (23%) or vitamin B<jats:sub>6<\/jats:sub> (20%) on the day of their first PMS record; after 1999, these figures fell to 3% for progestogen and vitamin B<jats:sub>6<\/jats:sub> with the majority of women instead being prescribed a selective serotonin reuptake inhibitor (28%) or combined oral contraceptive (17%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Recording of premenstrual syndrome diagnoses in UK primary care has declined substantially over time and preferred prescription treatment has changed from progestogen to selective serotonin reuptake inhibitor and combined oral contraceptives.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-010244","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T23:39:12Z","timestamp":1458344352000},"page":"e010244","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Recording and treatment of premenstrual syndrome in UK general practice: a retrospective cohort study"],"prefix":"10.1136","volume":"6","author":[{"given":"Cormac J","family":"Sammon","sequence":"first","affiliation":[{"name":"Department of Primary care and Population Health, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin","family":"Nazareth","sequence":"additional","affiliation":[{"name":"Department of Primary care and Population Health, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Primary care and Population Health, University College London, London, UK"},{"name":"Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,3,18]]},"reference":[{"key":"2025101812363721000_6.3.e010244.1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bpobgyn.2007.07.001","article-title":"Hormonal management of premenstrual syndrome","volume":"22","author":"Usman","year":"2008","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2025101812363721000_6.3.e010244.2","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. 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