{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T09:11:00Z","timestamp":1793697060603,"version":"4.5.1"},"reference-count":40,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2016,3,31]]},"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>There is a high incidence of blood transfusion following hip fractures in elderly patients. Tranexamic acid (TXA) has proven efficacy in decreasing blood loss in general trauma patients as well as patients undergoing elective orthopaedic surgery. A randomised controlled trial will measure the effect of TXA in a population of patients undergoing hip fracture surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a double-blinded, randomised placebo-controlled trial. Patients admitted through the emergency room that are diagnosed with an intertrochanteric or femoral neck fracture will be eligible for enrolment and randomised to either treatment with 1\u2005g of intravenous TXA or intravenous saline at the time of skin incision. Patients undergoing percutaneous intervention for non-displaced or minimally displaced femoral neck fractures will not be eligible for enrolment. Postoperative transfusion rates will be recorded and blood loss will be calculated from serial haematocrits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This protocol was approved by the Institutional Review Board (IRB) and is registered with clinicaltrials.gov. The findings of the trial will be disseminated through peer-reviewed journals and conference presentations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>NCT01940536.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2015-010676","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T14:34:39Z","timestamp":1466606079000},"page":"e010676","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Tranexamic acid in hip fracture patients: a protocol for a randomised, placebo controlled trial on the efficacy of tranexamic acid in reducing blood loss in hip fracture patients"],"prefix":"10.1136","volume":"6","clinical-trial-number":[{"clinical-trial-number":"nct01940536","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Elizabeth Bishop","family":"Gausden","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Hospital for Special Surgery, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R","family":"Garner","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Harborview Medical Center, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J","family":"Warner","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Hospital for Special Surgery, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Levack","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Hospital for Special Surgery, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M","family":"Nellestein","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Trauma, New York Presbyterian Hospital, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Tedore","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, New York Presbyterian Hospital, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Flores","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, New York Presbyterian Hospital, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean G","family":"Lorich","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Trauma, New York Presbyterian Hospital, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"2025121509395224000_6.6.e010676.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1462"},{"key":"2025121509395224000_6.6.e010676.2","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-200301000-00008"},{"key":"2025121509395224000_6.6.e010676.3","doi-asserted-by":"crossref","unstructured":"Heyes GJ , Tucker A , Marley D , et al . Predictors for 1-year mortality following hip fracture: a retrospective review of 465 consecutive patients. Eur J Trauma Emerg Surg 2015. [Epub ahead of print Aug 2015]. doi:10.1007\/s00068-015-0556-2","DOI":"10.1007\/s00068-015-0556-2"},{"key":"2025121509395224000_6.6.e010676.4","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-200101000-00007"},{"key":"2025121509395224000_6.6.e010676.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2014.10.051"},{"key":"2025121509395224000_6.6.e010676.6","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.00443"},{"key":"2025121509395224000_6.6.e010676.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.02.015"},{"key":"2025121509395224000_6.6.e010676.8","first-page":"437","article-title":"Does a single bolus dose of tranexamic acid reduce blood loss and transfusion requirements during hip fracture surgery? A prospective randomized double blind study in 67 patients","volume":"45","author":"Sadeghi","year":"2007","journal-title":"Acta Medica Iranica"},{"key":"2025121509395224000_6.6.e010676.9","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.128908"},{"key":"2025121509395224000_6.6.e010676.10","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep314"},{"key":"2025121509395224000_6.6.e010676.11","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.injury.2015.06.039","article-title":"The efficacy of tranexamic acid in hip hemiarthroplasty surgery: an observational cohort study","volume":"46","author":"Lee","year":"2015","journal-title":"Injury"},{"key":"2025121509395224000_6.6.e010676.12","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000022460.21283.53"},{"key":"2025121509395224000_6.6.e010676.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2012.01606.x"},{"key":"2025121509395224000_6.6.e010676.14","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.M.00825"},{"key":"2025121509395224000_6.6.e010676.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.09.015"},{"key":"2025121509395224000_6.6.e010676.16","doi-asserted-by":"crossref","first-page":"132","DOI":"10.5435\/00124635-201003000-00002","article-title":"Antifibrinolytics in major orthopaedic surgery","volume":"18","author":"Eubanks","year":"2010","journal-title":"J Am Acad Orthop Surg"},{"key":"2025121509395224000_6.6.e010676.17","doi-asserted-by":"crossref","first-page":"e82063","DOI":"10.1371\/journal.pone.0082063","article-title":"Efficacy and safety of using antifibrinolytic agents in spine surgery: a meta-analysis","volume":"8","author":"Yuan","year":"2013","journal-title":"PLoS ONE"},{"key":"2025121509395224000_6.6.e010676.18","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200611000-00026"},{"key":"2025121509395224000_6.6.e010676.19","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.01293"},{"key":"2025121509395224000_6.6.e010676.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60835-5"},{"key":"2025121509395224000_6.6.e010676.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60278-X"},{"key":"2025121509395224000_6.6.e010676.22","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-013-3134-0"},{"key":"2025121509395224000_6.6.e010676.23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00204.x"},{"key":"2025121509395224000_6.6.e010676.24","doi-asserted-by":"publisher","DOI":"10.1007\/BF03018543"},{"key":"2025121509395224000_6.6.e010676.25","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4829"},{"key":"2025121509395224000_6.6.e010676.26","doi-asserted-by":"crossref","first-page":"E1257","DOI":"10.1097\/BRS.0000000000001063","article-title":"Two doses of tranexamic acid reduce blood transfusion in complex spine surgery: a prospective randomized study","volume":"40:","author":"Raksakietisak","year":"2015","journal-title":"Spine"},{"key":"2025121509395224000_6.6.e010676.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2013.05.026"},{"key":"2025121509395224000_6.6.e010676.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2014.01.031"},{"key":"2025121509395224000_6.6.e010676.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.08.020"},{"key":"2025121509395224000_6.6.e010676.30","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1302\/0301-620X.97B4.34656","article-title":"Does tranexamic acid alter the risk of thromboembolism after total hip arthroplasty in the absence of routine chemical thromboprophylaxis?","volume":"97-B","author":"Nishihara","year":"2015","journal-title":"Bone Joint J"},{"key":"2025121509395224000_6.6.e010676.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2014.08.022"},{"key":"2025121509395224000_6.6.e010676.32","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.00873"},{"key":"2025121509395224000_6.6.e010676.33","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afm161"},{"key":"2025121509395224000_6.6.e010676.34","doi-asserted-by":"publisher","DOI":"10.1046\/j.0041-1132.2003.00581.x"},{"key":"2025121509395224000_6.6.e010676.35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4103\/1658-354X.109803","article-title":"Role of tranexamic acid in reducing postoperative blood loss and transfusion requirement in patients undergoing hip and femoral surgeries","volume":"7","author":"Vijay","year":"2013","journal-title":"Saudi J Anaesth"},{"key":"2025121509395224000_6.6.e010676.36","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-014-1457-5"},{"key":"2025121509395224000_6.6.e010676.37","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.N.00662"},{"key":"2025121509395224000_6.6.e010676.38","first-page":"77","article-title":"Tranexamic acid and orthopedic surgery-the search for the holy grail of blood conservation","volume":"3","author":"Danninger","year":"2015","journal-title":"Ann Transl Med"},{"key":"2025121509395224000_6.6.e010676.39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/ACO.0000000000000165","article-title":"Tranexamic acid: from trauma to routine perioperative use","volume":"28","author":"Simmons","year":"2015","journal-title":"Curr Opin Anaesthesiol"},{"key":"2025121509395224000_6.6.e010676.40","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-012-2488-z"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2015-010676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T17:41:12Z","timestamp":1765820472000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2015-010676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,21]]},"published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1136\/bmjopen-2015-010676"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2015-010676","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]}}}