{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T10:49:51Z","timestamp":1765709391648,"version":"3.48.0"},"reference-count":31,"publisher":"BMJ","issue":"5","funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI12C1889"],"award-info":[{"award-number":["HI12C1889"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2016,4,12]]},"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cancer-related anorexia is the loss of appetite or desire to eat in patients with cancer. Although treatments for cancer-related anorexia do exist, patients have sought complementary and alternative medicine including herbal remedies, due to safety concerns. Sipjeondaebo-tang is one among other popular herbal medicines that are beneficial to management of anorexia in Korea. The purpose of this study is to examine the feasibility for a full randomised clinical trial of Sipjeondaebo-tang for cancer-related anorexia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This study is a randomised, double-blinded and placebo-controlled trial of Sipjeondaebo-tang. For the study, 40 patients with cancer, aged 20\u201380\u2005years, who reported anorexia, will be recruited. The participants will receive either 3\u2005g of Sipjeondaebo-tang or a placebo, 3 times a day for 4\u2005weeks. The primary end point is a change in the anorexia\/cachexia subscale (A\/CS) of Functional Assessment of Anorexia\/Cachexia Therapy (FAACT). The secondary end points include changes in the visual analogue scale (VAS) of appetite, cortisol and ghrelin. The outcomes will be measured on every visit. Each participant will visit once a week during 4\u2005weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The present study has been approved by the Institutional Review Board of the Dunsan Korean Medicine Hospital of Daejeon University (reference DJDSKH-15-03-2 (V.2.0)). The results will be disseminated in a peer-reviewed journal and scientific conference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>NCT02468141; Pre-results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-011212","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T21:14:42Z","timestamp":1463087682000},"page":"e011212","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Sipjeondaebo-tang in patients with cancer with anorexia: a protocol for a pilot, randomised, controlled trial"],"prefix":"10.1136","volume":"6","author":[{"given":"Chunhoo","family":"Cheon","sequence":"first","affiliation":[{"name":"Department of Korean Preventive Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunju","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Lee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Korean Preventive Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Wen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Korean Preventive Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youme","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Korean Preventive Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Hyoung","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Korean Preventive Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Cheol","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Korean Preventive Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Gyu","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Korean Preventive Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"2025121402462480000_6.5.e011212.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"issue":"2","key":"2025121402462480000_6.5.e011212.2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000227126","article-title":"Clinical management of anorexia and cachexia in patients with advanced cancer","volume":"49","author":"Bruera","year":"1992","journal-title":"Oncology"},{"key":"2025121402462480000_6.5.e011212.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(05)80001-3"},{"key":"2025121402462480000_6.5.e011212.4","doi-asserted-by":"crossref","first-page":"e229","DOI":"10.14694\/EdBook_AM.2015.35.e229","article-title":"Current and future care of patients with the cancer anorexia-cachexia syndrome","volume":"35","author":"Del Fabbro","year":"2015","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"2025121402462480000_6.5.e011212.5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.8010"},{"key":"2025121402462480000_6.5.e011212.6","doi-asserted-by":"publisher","DOI":"10.2174\/138161212803216979"},{"key":"2025121402462480000_6.5.e011212.7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.078"},{"key":"2025121402462480000_6.5.e011212.8","doi-asserted-by":"publisher","DOI":"10.1177\/1534735409359180"},{"key":"2025121402462480000_6.5.e011212.9","doi-asserted-by":"crossref","first-page":"736563","DOI":"10.1155\/2014\/736563","article-title":"Effect of Sipjeondaebo-tang on cancer-induced anorexia and cachexia in CT-26 tumor-bearing mice","volume":"2014","author":"Choi","year":"2014","journal-title":"Mediators Inflamm"},{"key":"2025121402462480000_6.5.e011212.10","unstructured":"Korea Food and Drug Administration (KFDA). 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