{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:36:48Z","timestamp":1787017008683,"version":"build-2736575974"},"reference-count":30,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2016,4,26]]},"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effect of preconsultation C reactive protein (CRP) screening on antibiotic prescribing and referral to hospital in Norwegian primary care settings with low prevalence of serious infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Randomised controlled observational study at out-of-hours services in Norway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Primary care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>401 children (0\u20136\u2005years) with fever and\/or respiratory symptoms were recruited from 5 different out-of-hours services (including 1 paediatric emergency clinic) in 2013\u20132015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Data were collected from questionnaires and clinical examination results. Every third child was randomised to a CRP test before the consultation; for the rest, the doctor ordered a CRP test if considered necessary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>Main outcome variables were prescription of antibiotics and referral to hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the group pretested with CRP, the antibiotic prescription rate was 26%, compared with 22% in the control group. In the group pretested with CRP, 5% were admitted to hospital, compared with 9% in the control group. These differences were not statistically significant. The main predictors for ordering a CRP test were parents' assessment of seriousness of the illness and the child's temperature. Paediatricians ordered CRP tests less frequently than did other doctors (9% vs 56%, p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preconsultation screening with CRP of children presenting to out-of-hours services with fever and\/or respiratory symptoms does not significantly affect the prescription of antibiotics or referral to hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>NCT02496559; Results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-011231","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T21:14:42Z","timestamp":1463087682000},"page":"e011231","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Out-of-hours antibiotic prescription after screening with C reactive protein: a randomised controlled study"],"prefix":"10.1136","volume":"6","author":[{"given":"Ingrid Keilegavlen","family":"Rebnord","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hogne","family":"Sandvik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Batman Mjelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steinar","family":"Hunskaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"2024051609322223000_6.5.e011231.1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3109\/02813432.2012.684208","article-title":"Use of laboratory tests in out-of-hours services in Norway","volume":"30","author":"Rebnord","year":"2012","journal-title":"Scand J Prim Health Care"},{"key":"2024051609322223000_6.5.e011231.2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq033"},{"key":"2024051609322223000_6.5.e011231.3","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31825d2f76"},{"key":"2024051609322223000_6.5.e011231.4","unstructured":"NORM\/NORM-VET. Usage of antimicrobial agents and occurrence of antimicrobial resistance in Norway. Norwegian surveillance system for antimicrobial resistance (NORM) and Norwegian surveillance system for antimicrobial resistance in veterinary and food production sectors (NORM-VET). Norwegian Veterinary Institute, 2013."},{"key":"2024051609322223000_6.5.e011231.5","unstructured":"Sakshaug S , ed. Drug Consumption in Norway 2009\u20132013 (Legemiddelforbruket i Norge 2009\u20132013), Norwegian Institute of Public Health, Oslo, legemiddelstatistikk 2014:1"},{"key":"2024051609322223000_6.5.e011231.6","unstructured":"Norwegian Institute of Public Health. http:\/\/www.fhi.no\/artikler\/?id=112332Published 14.10.2014, updated 07.05.2015, 09:01"},{"key":"2024051609322223000_6.5.e011231.7","unstructured":"Linb\u00e6k M . Helsedirektoratet, Antibiotikasenteret for prim\u00e6rmedisin. Nasjonale faglige retningslinjer for antibiotikabruk i prim\u00e6rhelsetjenesten Oslo: Helsedirektoratet: Antibiotikasenteret for prim\u00e6rmedisin, 2013."},{"key":"2024051609322223000_6.5.e011231.8","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.203760"},{"key":"2024051609322223000_6.5.e011231.9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12875-015-0385-8","article-title":"Point-of-care testing with CRP in primary care: a registry-based observational study from Norway","volume":"16","author":"Rebnord","year":"2015","journal-title":"BMC Fam Pract"},{"key":"2024051609322223000_6.5.e011231.10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d3082"},{"key":"2024051609322223000_6.5.e011231.11","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmr119"},{"key":"2024051609322223000_6.5.e011231.12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38483.478183.EB"},{"key":"2024051609322223000_6.5.e011231.13","doi-asserted-by":"publisher","DOI":"10.1080\/00365540500335207"},{"key":"2024051609322223000_6.5.e011231.14","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2014.03.130315"},{"key":"2024051609322223000_6.5.e011231.15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-15-80"},{"key":"2024051609322223000_6.5.e011231.16","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp13X674477"},{"key":"2024051609322223000_6.5.e011231.17","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2012.06.110310"},{"key":"2024051609322223000_6.5.e011231.18","first-page":"2924","article-title":"[Changes in antibiotic consumption among day-care children in Oslo]","volume":"127","author":"Nordlie","year":"2007","journal-title":"Tidsskr Nor Laegeforen"},{"key":"2024051609322223000_6.5.e011231.19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4045\/tidsskr.09.0489","article-title":"[Working style among regular general practitioners and other doctors in the out-of-hours services]","volume":"130","author":"Sandvik","year":"2010","journal-title":"Tidsskr Nor Laegeforen"},{"key":"2024051609322223000_6.5.e011231.20","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-9-123"},{"key":"2024051609322223000_6.5.e011231.21","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp15X686497"},{"key":"2024051609322223000_6.5.e011231.22","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp13X669158"},{"key":"2024051609322223000_6.5.e011231.23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/13814788.2014.907267","article-title":"Respiratory virus infections in febrile children presenting to a general practice out-of-hours service","volume":"21","author":"Kool","year":"2015","journal-title":"Eur J Gen Pract"},{"key":"2024051609322223000_6.5.e011231.24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/2193-1801-2-124","article-title":"Antibiotic prescription preferences in paediatric outpatient setting in Estonia and Sweden","volume":"2","author":"Lass","year":"2013","journal-title":"Springerplus"},{"key":"2024051609322223000_6.5.e011231.25","doi-asserted-by":"crossref","first-page":"pii: e002285","DOI":"10.1136\/bmjopen-2012-002285","article-title":"Are children carrying the burden of broad-spectrum antibiotics in general practice? Prescription pattern for paediatric outpatients with respiratory tract infections in Norway","volume":"3","author":"Fossum","year":"2013","journal-title":"BMJ Open"},{"key":"2024051609322223000_6.5.e011231.26","doi-asserted-by":"publisher","DOI":"10.3109\/00365540903352932"},{"key":"2024051609322223000_6.5.e011231.27","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3109\/02813432.2015.1114348","article-title":"What a difference a CRP makes. A prospective observational study on how point-of-care C-reactive protein testing influences antibiotic prescription for respiratory tract infections in Swedish primary health care","volume":"33","author":"Lindstr\u00f6m","year":"2015","journal-title":"Scand J Prim Health Care"},{"key":"2024051609322223000_6.5.e011231.28","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmu037"},{"key":"2024051609322223000_6.5.e011231.29","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b1374"},{"key":"2024051609322223000_6.5.e011231.30","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f1706"}],"updated-by":[{"DOI":"10.1136\/bmjopen-2016-011231corr1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000}}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2016-011231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T12:35:38Z","timestamp":1715862938000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2016-011231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,12]]},"published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1136\/bmjopen-2016-011231"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2016-011231","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5]]}}}