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It is estimated that hip fracture accounts for 1.4% of total social and healthcare costs in the established market economies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The World Hip Trauma Evaluation (WHiTE) was set up to measure outcome in a comprehensive cohort of UK patients with hip fracture. All patients in the cohort are treated under a single comprehensive treatment pathway. A core outcome set, including health-related quality of life, is collected on all the patients. This protocol describes the current multicentre project that will be used as a vehicle to deliver a series of embedded observational studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Research Ethics Committee approval was granted (Rec reference 11\/LO\/0927, approved 18\/8\/2011) and each hospital trust provided National Health Service (NHS) approvals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      The study is registered with National Institute of Health Research Portfolio (UKCRN ID 12351) and the ISRCTN registry (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"isrctn\" xlink:href=\"63982700\">ISRCTN63982700<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-011679","type":"journal-article","created":{"date-parts":[[2016,10,22]],"date-time":"2016-10-22T00:03:08Z","timestamp":1477094588000},"page":"e011679","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["World Hip Trauma Evaluation (WHiTE): framework for embedded comprehensive cohort studies"],"prefix":"10.1136","volume":"6","clinical-trial-number":[{"clinical-trial-number":"isrctn63982700","registry":"10.18810\/isrctn"}],"author":[{"given":"Matthew L","family":"Costa","sequence":"first","affiliation":[{"name":"NDORMS (Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences), Kadoorie Centre, University of Oxford, John Radcliffe Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier L","family":"Griffin","sequence":"additional","affiliation":[{"name":"NDORMS (Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences), Kadoorie Centre, University of Oxford, John Radcliffe Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juul","family":"Achten","sequence":"additional","affiliation":[{"name":"NDORMS (Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences), Kadoorie Centre, University of Oxford, John Radcliffe Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"NDORMS (Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences), Kadoorie Centre, University of Oxford, John Radcliffe Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Judge","sequence":"additional","affiliation":[{"name":"NDORMS (Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences), University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Pinedo-Villanueva","sequence":"additional","affiliation":[{"name":"NDORMS (Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences), University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Parsons","sequence":"additional","affiliation":[{"name":"Warwick Medical School, University of Warwick, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,10,21]]},"reference":[{"key":"2025121523520316000_6.10.e011679.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1627-0"},{"key":"2025121523520316000_6.10.e011679.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2014.06.011"},{"key":"2025121523520316000_6.10.e011679.3","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000383"},{"key":"2025121523520316000_6.10.e011679.4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7418.771"},{"key":"2025121523520316000_6.10.e011679.5","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1302\/0301-620X.97B3.35738","article-title":"Recovery of health-related quality of life in a United Kingdom hip fracture population. 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