{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:05:26Z","timestamp":1781647526951,"version":"3.54.5"},"reference-count":32,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2016,6,3]]},"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the mortality rate following total ankle replacement (TAR) and incidence of 90\u2005day pulmonary embolism (PE) along with the associated risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Data-linkage study of the UK National Joint Registry (NJR) data and Hospital Episodes Statistics (HES) database. Linkage was performed in a deterministic fashion. HES episodes 90\u2005days after the index procedure were analysed for PE. Mortality data were obtained pertaining to all the index procedures from the NJR for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>All primary and revision ankle replacement patients captured on the NJR between February 2008 and February 2013.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 90-day mortality following TAR was 0.13% (95% CI 0.03 to 0.52) and 1-year mortality was 0.72% (95% CI 0.40 to 1.30); no deaths were as a result of PE. The incidence of PE within 90\u2005days following primary TAR was 0.51% (95% CI 0.23 to 1.13). There was only one PE following revision surgery. Patients with an Royal College of Surgeons Charlson score greater than zero were at 13 times greater risk of PE (p=0.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is low incidence of PE following TAR, but multiple comorbidities are a leading risk factor for its occurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-011947","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T14:34:39Z","timestamp":1466606079000},"page":"e011947","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Pulmonary embolism and mortality following total ankle replacement: a data linkage study using the NJR data set"],"prefix":"10.1136","volume":"6","author":[{"given":"Razi","family":"Zaidi","sequence":"first","affiliation":[{"name":"Institute of Orthopaedics & Musculoskeletal Science, Royal National Orthopaedic Hospital NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"MacGregor","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzie","family":"Cro","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit at UCL, Medical Research Council (MRC), London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics & Musculoskeletal Science, Royal National Orthopaedic Hospital NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"2025121513532592000_6.6.e011947.1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.95B11.31633"},{"key":"2025121513532592000_6.6.e011947.2","unstructured":"National Institute for Health and Clinical Excellence. 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