{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:28:11Z","timestamp":1788863291599,"version":"build-2803163510"},"reference-count":51,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2016,10,27]]},"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Acute coronary syndrome (ACS) is one of the leading causes of morbidity and mortality worldwide. Secondary cardiovascular risk reduction therapy (consisting of an aspirin, a \u03b2-blocker, an ACE inhibitor or an angiotensin II receptor blocker and a statin) is needed for all patients with ACS. Less than 80% of patients with ACS in Qatar use this combination after discharge. This study is aimed to evaluate the effectiveness of clinical pharmacist-delivered intervention at discharge and tailored follow-up postdischarge on decreasing hospital readmissions, emergency department (ED) visits and mortality among patients with ACS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>A prospective, randomised controlled trial will be conducted at the Heart Hospital in Qatar. Patients are eligible for enrolment if they are at least 18\u2005years of age and are discharged from any non-surgical cardiology service with ACS. Participants will be randomised into 1 of 3 arms: (1) \u2018control\u2019 arm which includes patients discharged during weekends or after hours; (2) \u2018clinical pharmacist delivered usual care at discharge\u2019 arm which includes patients receiving the usual care at discharge by clinical pharmacists; and (3) \u2018clinical pharmacist-delivered structured intervention at discharge and tailored follow-up postdischarge\u2019 arm which includes patients receiving intensive structured discharge interventions in addition to 2 follow-up sessions by intervention clinical pharmacists. Outcomes will be measured by blinded research assistants at 3, 6 and 12\u2005months after discharge and will include: all-cause hospitalisations and cardiac-related hospital readmissions (primary outcome), all-cause mortality including cardiac-related mortality, ED visits including cardiac-related ED visits, adherence to medications and treatment burden. Percentage of readmissions between the 3 arms will be compared on intent-to-treat basis using \u03c7<jats:sup>2<\/jats:sup> test with Bonferroni's adjusted pairwise comparisons if needed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>The study was ethically approved by the Qatar University and the Hamad Medical Corporation Institutional Review Boards. The results shall be disseminated in international conferences and peer-reviewed publications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trials registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02648243\" ext-link-type=\"uri\">NCT02648243<\/jats:ext-link>; pre-results.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-012141","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T22:01:00Z","timestamp":1479506460000},"page":"e012141","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of a pharmacist-delivered discharge and follow-up intervention for patients with acute coronary syndromes in Qatar: a study protocol for a randomised controlled trial"],"prefix":"10.1136","volume":"6","author":[{"given":"Amani","family":"Zidan","sequence":"first","affiliation":[{"name":"Clinical Pharmacy and Practice Section, Qatar University College of Pharmacy, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Awaisu","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy and Practice Section, Qatar University College of Pharmacy, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadir","family":"Kheir","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy and Practice Section, Qatar University College of Pharmacy, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyad","family":"Mahfoud","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine-Qatar, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Kaddoura","sequence":"additional","affiliation":[{"name":"Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaya","family":"AlYafei","sequence":"additional","affiliation":[{"name":"Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0770-4679","authenticated-orcid":false,"given":"Maguy Saffouh","family":"El Hajj","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy and Practice Section, Qatar University College of Pharmacy, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,11,18]]},"reference":[{"key":"2025101813444187000_6.11.e012141.1","unstructured":"WHO. 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