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We examine associations and pathways between life course violence and mobility disability in older participants of the International Mobility in Aging Study (IMIAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study using IMIAS 2012 baseline. Men and women aged 65\u201374\u2005years were recruited at 5 cities (n=1995): Kingston and Saint-Hyacinthe (Canada), Tirana (Albania), Manizales (Colombia) and Natal (Brazil). Mobility was assessed by the Short Physical Performance Battery (SPPB) and by 2 questions on difficulty in walking and climbing stairs. Childhood physical abuse history and the HITS instrument were used to gather information on childhood exposure to violence and violence by intimate partners or family members. Multivariate logistic regression and mediation analysis models were constructed to explore the significance of direct and indirect effects of violence on mobility. Interaction effects of gender on violence and on each of the mediators were tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Experiences of physical violence at any point of life were associated with mobility disability (defined as SPPB&lt;8 or limitation in walking\/climbing stairs) while psychological violence was not. Chronic conditions, C reactive protein, physical activity and depression mediated the effect of childhood exposure to violence on both mobility outcomes. Chronic conditions and depression were pathways between family and partner violence and both mobility outcomes. Physical activity was a significant pathway linking family violence to mobility. Gender interactions were not significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results provide evidence for the detrimental effects of life course exposure to violence on mobility in later life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-012339","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T22:54:30Z","timestamp":1476399270000},"page":"e012339","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Experiences of violence across life course and its effects on mobility among participants in the International Mobility in Aging Study"],"prefix":"10.1136","volume":"6","author":[{"given":"Dimitri Taurino","family":"Guedes","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Faculdade de Ci\u00eancias da Sa\u00fade do Trairi, Universidade Federal do Rio Grande do Norte, Santa Cruz, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afshin","family":"Vafaei","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Queen's University, Kingston, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Eugenia","family":"Alvarado","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Queen's University, Kingston, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Lucia","family":"Curcio","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack M","family":"Guralnik","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Maryland, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Victoria","family":"Zunzunegui","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Sociale et Pr\u00e9ventive, \u00c9cole de Sant\u00e9 Publique, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Oliveira","family":"Guerra","sequence":"additional","affiliation":[{"name":"Departamento de Fisioterapia, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Rio Grande do Norte, Natal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,10,13]]},"reference":[{"key":"2025121400355096000_6.10.e012339.1","doi-asserted-by":"publisher","DOI":"10.1007\/s10464-005-9009-0"},{"key":"2025121400355096000_6.10.e012339.2","doi-asserted-by":"publisher","DOI":"10.1177\/0898264305280994"},{"key":"2025121400355096000_6.10.e012339.3","doi-asserted-by":"crossref","unstructured":"Bonomi AE , Kernic MA , Anderson ML , et al . 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