{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:19:29Z","timestamp":1765779569108,"version":"3.48.0"},"reference-count":34,"publisher":"BMJ","issue":"4","funder":[{"name":"Veneto Region Authority"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2016,12,7]]},"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Epidemiology of\n                      <jats:italic>Neisseria meningitidis<\/jats:italic>\n                      has been changing since the introduction of universal vaccination programmes against meningococcal serogroup C (MenC) and meningococcal serogroup B (MenB) has now become dominant. This study aimed to analyse the cases reported in institutional data recording systems to estimate the burden of invasive meningococcal diseases (IMDs) and assess the effectiveness of surveillance in Veneto region (Italy).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Analysis was performed from 2007 to 2014 on data recorded in different systems: Mandatory Notification System, National Surveillance of Invasive Bacterial Diseases System and Laboratories Surveillance System (LSS), which were pooled into a combined surveillance system (CSS) and hospital discharge records (HDRs). A capture-recapture method was used and completeness of each source estimated. Number of cases with IMD by source of information and year, incidence of IMD by age group, case fatality rate (CFR) and distribution of meningococcal serogroups by year were also analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Combining the four data systems enabled the identification of 179 confirmed cases with IMD, achieving an overall sensitivity of 94.7% (95% CI: 90.8% to 98.8%), while it was 76.7% (95% CI: 73.6% to 80.1%) for CSS and 77.2% (95% CI: 74.1% to 80.6%) for HDRs. Typing of isolates was done in 80% of cases, and 95.2% of the typed cases were provided by LSS. Serogroup B was confirmed in 50.3% of cases. The estimated IMD notification rate (cases with IMD diagnosed and reported to the surveillance systems) was 0.48\/100 000 population, and incidence peaked at 6.2\/100 000 in children aged &lt;1\u2009year old (60.9% due to MenB), and increased slightly in the age group between 15 and 19 years (1.1\/100 000). A CFR of 14% was recorded (8.7% in paediatric age).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Quality of surveillance systems relies on case ascertainment based on serological characterisation of the circulating strains by microbiology laboratories. All available sources should be routinely combined to improve the epidemiology of IMD and the information used by public health departments to conduct timely preventive measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-012478","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T20:10:45Z","timestamp":1493755845000},"page":"e012478","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Invasive meningococcal disease in the Veneto region of Italy: a capture-recapture analysis for assessing the effectiveness of an integrated surveillance system"],"prefix":"10.1136","volume":"7","author":[{"given":"Tatjana","family":"Baldovin","sequence":"first","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences, Hygiene and Public Health Unit, University of Padua, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Lazzari","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences, Hygiene and Public Health Unit, University of Padua, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Cocchio","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences, Hygiene and Public Health Unit, University of Padua, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Furlan","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences, Hygiene and Public Health Unit, University of Padua, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Bertoncello","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences, Hygiene and Public Health Unit, University of Padua, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Saia","sequence":"additional","affiliation":[{"name":"Area Sanit\u00e0 e Sociale, Veneto Regional Authority, Venice, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Russo","sequence":"additional","affiliation":[{"name":"Service of Hygiene Promotion and Development and Public Health, Veneto Region, Venice, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Baldo","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences, Hygiene and Public Health Unit, University of Padua, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,5,2]]},"reference":[{"key":"2025121422142997000_7.4.e012478.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.02.058"},{"key":"2025121422142997000_7.4.e012478.2","unstructured":"Greenwood BM . The epidemiology of acute bacterial meningitis in tropical Africa. In: Williams JD , Burnie J , eds. Bacterial meningitis. London: Academic Press, 1987:61\u201391."},{"key":"2025121422142997000_7.4.e012478.3","unstructured":"Centers for Disease Control. Active bacterial corecore surveillance (ABCs) report emerging infections program network Neisseria meningitidis, 2009. Available on. http:\/\/www.cdc.gov\/abcs\/reports-findings\/survreports\/mening09.pdf. 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Dati di sorveglianza delle malattie batteriche invasive aggiornati al 4 aprile 2016. http:\/\/www.iss.it\/binary\/mabi\/cont\/Report_MBI_20160404.pdf (accessed 12th Sep 2016)."},{"key":"2025121422142997000_7.4.e012478.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2011.10.002"},{"key":"2025121422142997000_7.4.e012478.10","first-page":"169","article-title":"Completeness and timeliness of reporting of meningococcal disease-Maine, 2001-2006","volume":"58","author":"Centers for Disease Control and Prevention (CDC)","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2025121422142997000_7.4.e012478.11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.17269\/cjph.104.3755","article-title":"Challenges to the surveillance of meningococcal disease in an era of declining incidence in Montr\u00e9al, Qu\u00e9bec","volume":"104","author":"Ratnayake","year":"2013","journal-title":"Can J Public Health"},{"key":"2025121422142997000_7.4.e012478.12","doi-asserted-by":"publisher","DOI":"10.1586\/erv.11.159"},{"key":"2025121422142997000_7.4.e012478.13","unstructured":"Commission decision of 28 April 2008 amending decision 2002\/253\/EC laying down case definitions for reporting communicable diseases to the Community network under Decision No 2119\/98\/EC of the European Parliament and of the Council (notified under document number C(2008) 1589). 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