{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T09:01:38Z","timestamp":1765875698998,"version":"3.48.0"},"reference-count":19,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2016,7,26]]},"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Children under the age of 12\u2005months may receive an early dose of measles\u2013mumps\u2013rubella (MMR) vaccine to provide short-term protection in the case of a disease outbreak. Following a measles outbreak in Alberta, Canada, there was concern that children who received an early dose may not be returning for their routinely scheduled dose at 12\u2005months, leaving them vulnerable to disease in the long term.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This population-based study of children born between 2006 and 2014 used administrative health data to assess coverage and timeliness of the first routine dose of MMR vaccine administered at age 12\u201324\u2005months for children who received an early dose of the vaccine due to a disease outbreak. We compared this group to children who received an early dose due to travel to a measles-endemic region and to children who did not receive an early dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Only 5.5% of 366\u2005351 children received an early dose. Coverage for the routine dose at age 24\u2005months was 96.5% for children receiving an outbreak dose, 92.2% for those travelling to measles-endemic regions and 86.6% for those without an early dose (p&lt;0.0001). The multivariable Cox proportional hazard analysis, controlling for neighbourhood income, place of residence and interaction effects, determined that, as compared to the general cohort, the outbreak group was most likely to obtain the first routine dose (adjusted HR (aHR): 1.52, 95% CI 1.44 to 1.60), followed by the travel group (aHR: 1.26, 95% CI 1.18 to 1.34).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It is reassuring that the majority of children who received an early dose returned for their routine dose and did so in a timely manner.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-012803","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T23:13:24Z","timestamp":1472685204000},"page":"e012803","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Do children who receive an \u2018early dose\u2019 of MMR vaccine during a measles outbreak return for their regularly scheduled dose? A retrospective population-based study"],"prefix":"10.1136","volume":"6","author":[{"given":"Xiaoyan","family":"Guo","sequence":"first","affiliation":[{"name":"Analytics and Performance Reporting Branch, Alberta Ministry of Health, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberley A","family":"Simmonds","sequence":"additional","affiliation":[{"name":"Strategic Planning and Policy Division, Alberta Ministry of Health, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Svenson","sequence":"additional","affiliation":[{"name":"Health and Wellness Promotion Branch, Alberta Ministry of Health, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon E","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,8,31]]},"reference":[{"key":"2025121600581540000_6.8.e012803.1","unstructured":"Centers for Disease Control and Prevention (CDC). Measles Cases and Outbreaks. CDC . http:\/\/www.cdc.gov\/measles\/cases-outbreaks.html. Updated 10 February 2016."},{"key":"2025121600581540000_6.8.e012803.2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.14745\/ccdr.v40i12a07","article-title":"The challenges of sustaining measles elimination in Canada","volume":"40","author":"Crowcroft","year":"2014","journal-title":"CCDR"},{"key":"2025121600581540000_6.8.e012803.3","unstructured":"European Centre for Disease Prevention and Control (ECDC). Surveillance data. ECDC . http:\/\/ecdc.europa.eu\/en\/healthtopics\/measles\/epidemiological_data\/pages\/annual_epidemiological_reports.aspx Updated 3 March 2016."},{"key":"2025121600581540000_6.8.e012803.4","doi-asserted-by":"publisher","DOI":"10.3201\/eid1903.121360"},{"key":"2025121600581540000_6.8.e012803.5","unstructured":"Public Heath Agency of Canada (PHAC). Canadian Immunization Guide: Timing of vaccine administration. http:\/\/www.phac-aspc.gc.ca\/publicat\/cig-gci\/p01-09-eng.php Updated 18 February 2016."},{"key":"2025121600581540000_6.8.e012803.6","unstructured":"Public Health Agency of Canada (PHAC). Canadian Immunization Guide: Part 1-Key immunization information. http:\/\/www.phac-aspc.gc.ca\/publicat\/cig-gci\/p01-eng.php Updated 23 April 2014."},{"issue":"RR-8","key":"2025121600581540000_6.8.e012803.7","first-page":"1","article-title":"Measles, Mumps, and Rubella vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps: Recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"47","author":"Centers for Disease Control and Prevention (CDC)","year":"1998","journal-title":"MMWR"},{"key":"2025121600581540000_6.8.e012803.8","unstructured":"Alberta Health. Routine immunization schedule. Alberta Health . http:\/\/www.health.alberta.ca\/health-info\/imm-routine-schedule.html Updated 1 June 2015."},{"key":"2025121600581540000_6.8.e012803.9","unstructured":"Statistics Canada. Census of population program datasets. Statistics Canada. http:\/\/www12.statcan.gc.ca\/datasets\/index-eng.cfm?Temporal=2011 Updated 13 November 2015."},{"key":"2025121600581540000_6.8.e012803.10","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.11.1064"},{"key":"2025121600581540000_6.8.e012803.11","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.159.5.470"},{"key":"2025121600581540000_6.8.e012803.12","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2015.964212"},{"key":"2025121600581540000_6.8.e012803.13","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.4161\/21645515.2014.970075","article-title":"Parental concern about vaccine safety in Canadian children partially immunized at age 2: a multivariable model including system level factors","volume":"10","author":"MacDonald","year":"2014","journal-title":"Hum Vaccin Immunother"},{"key":"2025121600581540000_6.8.e012803.14","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3637"},{"key":"2025121600581540000_6.8.e012803.15","unstructured":"Alberta Health. Vaccine uptake following a measles outbreak in Alberta. 2015. http:\/\/www.health.alberta.ca\/documents\/HTA-2015-04-14-Measles-Vaccine-Outbreak.pdf Posted 14 April 2015."},{"key":"2025121600581540000_6.8.e012803.16","unstructured":"Alberta Health. Immunization: Childhood coverage rates. Interactive Health Data Application . Updated April 2016. http:\/\/www.ahw.gov.ab.ca\/IHDA_Retrieval\/selectSubCategoryParameters.do"},{"key":"2025121600581540000_6.8.e012803.17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.5.e58"},{"key":"2025121600581540000_6.8.e012803.18","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2784"},{"key":"2025121600581540000_6.8.e012803.19","first-page":"S61","article-title":"Addressing immunization barriers, benefits, and risks","volume":"56","author":"Kimmel","year":"2007","journal-title":"J Fam Pract"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2016-012803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T08:58:24Z","timestamp":1765875504000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2016-012803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":19,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,31]]},"published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1136\/bmjopen-2016-012803"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2016-012803","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2016,8]]}}}