{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:37:18Z","timestamp":1787017038051,"version":"build-2736575974"},"reference-count":14,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,1,26]]},"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess 2-year durability of joint contracture correction following collagenase injections for Dupuytren's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Orthopaedic Department in Sweden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients with palpable Dupuytren's cord and active extension deficit (AED) \u226530\u00b0 in the metacarpophalangeal (MCP) and\/or proximal interphalangeal (PIP) joint. A surgeon injected 0.80\u2005mg collagenase into multiple cord parts and performed finger manipulation under local anaesthesia after 24\u201348\u2005hours. A hand therapist measured joint contracture before and 5\u2005weeks after injection in all treated patients. Of 57 consecutive patients (59 hands), 48 patients (50 hands) were examined by a hand therapist 24\u201335\u2005months (mean 26) after injection. Five of the patients had received a second injection in the same finger within 6\u2005months of the first injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>Primary outcome was proportion of treated joints with \u226520\u00b0 worsening in AED from 5\u2005weeks to 2\u2005years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between the 5-week and the 2-year measurements, AED had worsened by \u226520\u00b0 in seven MCP and seven PIP joints (28% of the treated hands; all had received a single injection). Mean AED for the MCP joints was 54\u00b0 before injection, 6\u00b0 at 5\u2005weeks and 9\u00b0 at 2\u2005years and for the PIP joints 30\u00b0, 13\u00b0 and 16\u00b0, respectively. For joints with \u226510\u00b0 contracture at baseline, mean (95 % CI) baseline to 2\u2005years AED improvement was for MCP 49\u00b0 (41\u201354) and for PIP 25\u00b0 (17\u201332). No treatment-related adverse events were observed at the 2-year follow-up evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Two years after collagenase injections for Dupuytren's disease, improvement was maintained in 72% of the treated hands. Complete contracture correction was seen in more than 80% of the MCP but in less than half of the PIP joints.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-012943","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T20:50:21Z","timestamp":1489611021000},"page":"e012943","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Collagenase injections for Dupuytren's disease: prospective cohort study assessing 2-year treatment effect durability"],"prefix":"10.1136","volume":"7","author":[{"given":"Anna","family":"Lauritzson","sequence":"first","affiliation":[{"name":"Department of Orthopedics, H\u00e4ssleholm-Kristianstad-Ystad Hospitals, H\u00e4ssleholm, Sweden"},{"name":"Department of Rehabilitation, H\u00e4ssleholm Hospital, H\u00e4ssleholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isam","family":"Atroshi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, H\u00e4ssleholm-Kristianstad-Ystad Hospitals, H\u00e4ssleholm, Sweden"},{"name":"Department of Clinical Sciences\u2014Orthopedics, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"2025120518555511000_7.3.e012943.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810866"},{"key":"2025120518555511000_7.3.e012943.2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s40267-016-0291-8","article-title":"Collagenase clostridium histolyticum in Dupuytren's contracture: a guide to its use in the EU","volume":"32","author":"McKeage","year":"2016","journal-title":"Drugs Ther Perspect"},{"key":"2025120518555511000_7.3.e012943.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2015.06.099"},{"key":"2025120518555511000_7.3.e012943.4","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004166"},{"key":"2025120518555511000_7.3.e012943.5","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2015.1019782"},{"key":"2025120518555511000_7.3.e012943.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2012.09.028"},{"key":"2025120518555511000_7.3.e012943.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2015.04.036"},{"key":"2025120518555511000_7.3.e012943.8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-7-44"},{"key":"2025120518555511000_7.3.e012943.9","doi-asserted-by":"publisher","DOI":"10.1177\/1753193415597421"},{"key":"2025120518555511000_7.3.e012943.10","first-page":"CD010143","article-title":"Surgery for Dupuytren's contracture of the fingers","volume":"12","author":"Rodrigues","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2025120518555511000_7.3.e012943.11","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.jhsa.2014.04.029","article-title":"Hand function and quality of life before and after fasciectomy for Dupuytren contracture","volume":"39","author":"Engstrand","year":"2014","journal-title":"J Hand Surg Am"},{"key":"2025120518555511000_7.3.e012943.12","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31823aea95"},{"key":"2025120518555511000_7.3.e012943.13","unstructured":"HAKIR\u2014Swedish National Quality Register for Hand Surgery. Annual Report 2014 . 21\u201322. http:\/\/hakir.se\/rapporter\/ (accessed 3 Jan 2017)."},{"key":"2025120518555511000_7.3.e012943.14","doi-asserted-by":"publisher","DOI":"10.1177\/1753193415617385"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2016-012943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T02:56:06Z","timestamp":1764989766000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2016-012943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,15]]},"published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1136\/bmjopen-2016-012943"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2016-012943","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}