{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:47:49Z","timestamp":1787496469900,"version":"build-2736575974"},"reference-count":35,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2016,8,17]]},"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the effect of interleukin (IL)-6 and TIE2 gene polymorphisms on baseline peritoneal transport property.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>An observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Renji Hospital in Shanghai, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>This study included 220 patients with continuous ambulatory peritoneal dialysis (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>Patients were divided into 2 groups based on the results of an initial peritoneal equilibration test performed within 3\u2005months of starting PD therapy: group 1 consisted of low\/low average transporters (n=123), and group 2 consisted of high\/high average transporters (n=97). We genotyped TIE2 and IL-6 polymorphisms and analysed their effects on baseline transport status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The genotype AT in IL-6 Rs13306435 and the genotype CC in TIE2 Rs639225 were both negatively associated with a higher initial peritoneal transport status (IL-6 Rs13306435: OR=0.408, 95% CI 0.227 to 0.736; TIE2 Rs639225: OR=0.188, 95% CI 0.044 to 0.806).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IL-6 and TIE2 polymorphisms are associated with baseline peritoneal transport property.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-012967","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T22:59:32Z","timestamp":1477522772000},"page":"e012967","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Possible role of IL-6 and TIE2 gene polymorphisms in predicting the initial high transport status in patients with peritoneal dialysis: an observational study"],"prefix":"10.1136","volume":"6","author":[{"given":"Li","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghua","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liou","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanzhe","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaojun","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbei","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,10,26]]},"reference":[{"issue":"2","key":"2025120618351377000_6.10.e012967.1","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1177\/089686080902902S17","article-title":"Rapid solute transport in the peritoneum: physiologic and clinical consequences","volume":"29","author":"Cueto-Manzano","year":"2009","journal-title":"Perit Dial Int"},{"key":"2025120618351377000_6.10.e012967.2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1177\/089686088700700306","article-title":"Peritoneal equilibration test","volume":"7","author":"Twardowski","year":"1987","journal-title":"Perit Dial Bull"},{"key":"2025120618351377000_6.10.e012967.3","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1681\/ASN.V971285","article-title":"Increased peritoneal membrane transport is associated with decreased patient and technique survival for continuous peritoneal dialysis patients. 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